DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ubqn and UBQLN2

DIOPT Version :9

Sequence 1:	NP_001285457.1	Gene:	Ubqn / 32977	FlyBaseID:	FBgn0031057	Length:	547	Species:	Drosophila melanogaster
Sequence 2:	NP_038472.2	Gene:	UBQLN2 / 29978	HGNCID:	12509	Length:	624	Species:	Homo sapiens

Alignment Length:	618	Identity:	285/618 - (46%)
Similarity:	390/618 - (63%)	Gaps:	98/618 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 AEGGS------KRINVVVKTPKDKKTVEVDEDSGIKDFKILVAQKFEAEPEQLVLIFAGKIMKDT 60
            |:|.:      |.|.|.|||||:|:...|.|:|.::.||..::::|:::.:||||||||||:||.
Human    20 AQGSAAAPAEPKIIKVTVKTPKEKEEFAVPENSSVQQFKEAISKRFKSQTDQLVLIFAGKILKDQ 84

  Fly    61 DTLQMHNIKDNLTVHLVIKA---PTRNNEQPAR----------------QPADVRQTPFGLNQFG 106
            |||..|.|.|.||||||||:   |...:.||:.                .|......||||...|
Human    85 DTLIQHGIHDGLTVHLVIKSQNRPQGQSTQPSNAAGTNTTSASTPRSNSTPISTNSNPFGLGSLG 149

  Fly   107 GLAGMEALGAGSNTFMDLQARMQNELLNNGDMLRSLMDNPMVQQMMNNPDTMRQLITSNPQMHDL 171
            ||||:.:||..|..|.:||::||.:|:.:.:|:..:|:||.||.|::|||.|||||.:||||..|
Human   150 GLAGLSSLGLSSTNFSELQSQMQQQLMASPEMMIQIMENPFVQSMLSNPDLMRQLIMANPQMQQL 214

  Fly   172 MQRNPEISHMLNNPDLLRQTMELARNPSMLQELMRSHDRAMSNLESVPGGYSALQRIYRDIQEPM 236
            :||||||||:|||||::|||:|:||||:|:||:||:.|.|:|||||:||||:||:|:|.||||||
Human   215 IQRNPEISHLLNNPDIMRQTLEIARNPAMMQEMMRNQDLALSNLESIPGGYNALRRMYTDIQEPM 279

  Fly   237 MNAATESFGRNPFAGLVDGGGSGAGNNPQQGTENRNPLPNPW-------GGANSGTNGTVGGSGA 294
            :|||.|.||.||||.:.....||.|..|.: ||||:||||||       ..|.:.|. |..|||:
Human   280 LNAAQEQFGGNPFASVGSSSSSGEGTQPSR-TENRDPLPNPWAPPPATQSSATTSTT-TSTGSGS 342

  Fly   295 GNPTGDLPPN---------NVLNTPAMRSLLQQMADNPAMMQNLLNAPYTRSMMESMSQDPDMAA 350
            ||.:.:...|         ::.:||.|:|||||:.:||.::||:|:|||.||||:|:||:||:||
Human   343 GNSSSNATGNTVAAANYVASIFSTPGMQSLLQQITENPQLIQNMLSAPYMRSMMQSLSQNPDLAA 407

  Fly   351 RLLSSSPLMSNNPALQEQVRQMMPQFMAQMQNPEVMNMLTNPDAMNAILQIQQGMEQLRSAAPGL 415
            :::.:|||.:.||.||||:|..:|.|:.|||||:.::.::||.||.|::|||||::.|.:.||||
Human   408 QMMLNSPLFTANPQLQEQMRPQLPAFLQQMQNPDTLSAMSNPRAMQALMQIQQGLQTLATEAPGL 472

  Fly   416 VGTLGIPPPPPGAGTG-----------------------------------TNPAS---GDGSGG 442
                 ||...||.|.|                                   |.||:   ..||||
Human   473 -----IPSFTPGVGVGVLGTAIGPVGPVTPIGPIGPIVPFTPIGPIGPIGPTGPAAPPGSTGSGG 532

  Fly   443 NSGASTNNVSPSSGLNAGTGTPNLAPGGGPNAQLFNDFMMRMLNGMSN-NADNTQPPEVRYQSQL 506
            .:|.:.::.:||.       |.:.....|||.|    |:.:|:..::. ||.....||||:|.||
Human   533 PTGPTVSSAAPSE-------TTSPTSESGPNQQ----FIQQMVQALAGANAPQLPNPEVRFQQQL 586

  Fly   507 EQLNAMGFVNRDANLQALIATFGDINAAVERLL 539
            ||||||||:||:|||||||||.||||||:||||
Human   587 EQLNAMGFLNREANLQALIATGGDINAAIERLL 619

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ubqn	NP_001285457.1	UBQ	9..79	CDD:214563	38/69 (55%)
		hPLIC_N	9..79	CDD:176403	38/69 (55%)
		STI1	322..368	CDD:128966	26/45 (58%)
		UBA_PLICs	501..537	CDD:270582	29/35 (83%)
UBQLN2	NP_038472.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..32		2/11 (18%)
		UBQ	33..103	CDD:214563	38/69 (55%)
		hPLIC_N	33..103	CDD:176403	38/69 (55%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	106..141		4/34 (12%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	287..349		28/63 (44%)
		STI1	382..426	CDD:128966	25/43 (58%)
		12 X 3 AA tandem repeats of P-X-X	491..526		3/34 (9%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	512..556		12/50 (24%)
		UBA_PLICs	581..620	CDD:270582	33/39 (85%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	85	1.000	Domainoid score	I8158
eggNOG	1	0.900	-	-		E1_COG5272
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	538	1.000	Inparanoid score	I1196
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG54270
OrthoDB	1	1.010	-	-		D1553668at2759
OrthoFinder	1	1.000	-	-		FOG0001496
OrthoInspector	1	1.000	-	-		otm40720
orthoMCL	1	0.900	-	-		OOG6_100933
Panther	1	1.100	-	-	O	PTHR10677
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X761
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	13	12.840