DRSC/TRiP Functional Genomics Resources

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Protein Alignment Ubqn and UBQLN2

DIOPT Version :10

Sequence 1:NP_608344.1 Gene:Ubqn / 32977 FlyBaseID:FBgn0031057 Length:547 Species:Drosophila melanogaster
Sequence 2:NP_038472.2 Gene:UBQLN2 / 29978 HGNCID:12509 Length:624 Species:Homo sapiens


Alignment Length:618 Identity:285/618 - (46%)
Similarity:390/618 - (63%) Gaps:98/618 - (15%)


- Green bases have known domain annotations that are detailed below.


  Fly     2 AEGGS------KRINVVVKTPKDKKTVEVDEDSGIKDFKILVAQKFEAEPEQLVLIFAGKIMKDT 60
            |:|.:      |.|.|.|||||:|:...|.|:|.::.||..::::|:::.:||||||||||:||.
Human    20 AQGSAAAPAEPKIIKVTVKTPKEKEEFAVPENSSVQQFKEAISKRFKSQTDQLVLIFAGKILKDQ 84

  Fly    61 DTLQMHNIKDNLTVHLVIKA---PTRNNEQPAR----------------QPADVRQTPFGLNQFG 106
            |||..|.|.|.||||||||:   |...:.||:.                .|......||||...|
Human    85 DTLIQHGIHDGLTVHLVIKSQNRPQGQSTQPSNAAGTNTTSASTPRSNSTPISTNSNPFGLGSLG 149

  Fly   107 GLAGMEALGAGSNTFMDLQARMQNELLNNGDMLRSLMDNPMVQQMMNNPDTMRQLITSNPQMHDL 171
            ||||:.:||..|..|.:||::||.:|:.:.:|:..:|:||.||.|::|||.|||||.:||||..|
Human   150 GLAGLSSLGLSSTNFSELQSQMQQQLMASPEMMIQIMENPFVQSMLSNPDLMRQLIMANPQMQQL 214

  Fly   172 MQRNPEISHMLNNPDLLRQTMELARNPSMLQELMRSHDRAMSNLESVPGGYSALQRIYRDIQEPM 236
            :||||||||:|||||::|||:|:||||:|:||:||:.|.|:|||||:||||:||:|:|.||||||
Human   215 IQRNPEISHLLNNPDIMRQTLEIARNPAMMQEMMRNQDLALSNLESIPGGYNALRRMYTDIQEPM 279

  Fly   237 MNAATESFGRNPFAGLVDGGGSGAGNNPQQGTENRNPLPNPW-------GGANSGTNGTVGGSGA 294
            :|||.|.||.||||.:.....||.|..|.: ||||:||||||       ..|.:.|. |..|||:
Human   280 LNAAQEQFGGNPFASVGSSSSSGEGTQPSR-TENRDPLPNPWAPPPATQSSATTSTT-TSTGSGS 342

  Fly   295 GNPTGDLPPN---------NVLNTPAMRSLLQQMADNPAMMQNLLNAPYTRSMMESMSQDPDMAA 350
            ||.:.:...|         ::.:||.|:|||||:.:||.::||:|:|||.||||:|:||:||:||
Human   343 GNSSSNATGNTVAAANYVASIFSTPGMQSLLQQITENPQLIQNMLSAPYMRSMMQSLSQNPDLAA 407

  Fly   351 RLLSSSPLMSNNPALQEQVRQMMPQFMAQMQNPEVMNMLTNPDAMNAILQIQQGMEQLRSAAPGL 415
            :::.:|||.:.||.||||:|..:|.|:.|||||:.::.::||.||.|::|||||::.|.:.||||
Human   408 QMMLNSPLFTANPQLQEQMRPQLPAFLQQMQNPDTLSAMSNPRAMQALMQIQQGLQTLATEAPGL 472

  Fly   416 VGTLGIPPPPPGAGTG-----------------------------------TNPAS---GDGSGG 442
                 ||...||.|.|                                   |.||:   ..||||
Human   473 -----IPSFTPGVGVGVLGTAIGPVGPVTPIGPIGPIVPFTPIGPIGPIGPTGPAAPPGSTGSGG 532

  Fly   443 NSGASTNNVSPSSGLNAGTGTPNLAPGGGPNAQLFNDFMMRMLNGMSN-NADNTQPPEVRYQSQL 506
            .:|.:.::.:||.       |.:.....|||.|    |:.:|:..::. ||.....||||:|.||
Human   533 PTGPTVSSAAPSE-------TTSPTSESGPNQQ----FIQQMVQALAGANAPQLPNPEVRFQQQL 586

  Fly   507 EQLNAMGFVNRDANLQALIATFGDINAAVERLL 539
            ||||||||:||:|||||||||.||||||:||||
Human   587 EQLNAMGFLNREANLQALIATGGDINAAIERLL 619

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
UbqnNP_608344.1 Ubl_PLICs 7..79 CDD:340506 39/71 (55%)
PABP-1234 <233..409 CDD:130689 91/191 (48%)
UBA_PLICs 501..537 CDD:270582 29/35 (83%)
UBQLN2NP_038472.2 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..32 2/11 (18%)
Ubl_PLICs 31..103 CDD:340506 39/71 (55%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 106..141 4/34 (12%)
STI1 182..215 CDD:128966 18/32 (56%)
STI1 208..253 CDD:450205 31/44 (70%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 287..349 28/63 (44%)
STI1 382..426 CDD:128966 25/43 (58%)
12 X 3 AA tandem repeats of P-X-X 491..526 3/34 (9%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 512..556 12/50 (24%)
UBA_PLICs 581..620 CDD:270582 33/39 (85%)

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