DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment dome and OSMR

DIOPT Version :9

Sequence 1:	NP_523412.1	Gene:	dome / 32976	FlyBaseID:	FBgn0043903	Length:	1282	Species:	Drosophila melanogaster
Sequence 2:	NP_001310435.1	Gene:	OSMR / 9180	HGNCID:	8507	Length:	980	Species:	Homo sapiens

Alignment Length:	1193	Identity:	222/1193 - (18%)
Similarity:	382/1193 - (32%)	Gaps:	443/1193 - (37%)

- Green bases have known domain annotations that are detailed below.

  Fly   193 FSETFYFRLSISNALGHETQPITINHFERLVPARPGQNLTLLNRTESSVCLSW---EMPRRSNYN 254
            |..||:  |::.:...::::.:.    ||| |..|.......|.|..|:.|.|   .:|    |:
Human     7 FQTTFF--LTLLSLRTYQSEVLA----ERL-PLTPVSLKVSTNSTRQSLHLQWTVHNLP----YH 60

  Fly   255 RGL--VWQVRVTPQNFEPITRPSW-RNHTLTIKDTLCL-----TELPFAGYNYTLRVRVRANQNN 311
            :.|  |:|::::......:.   | .|::.|:|....|     :|||.....:.  ||:::..::
Human    61 QELKMVFQIQISRIETSNVI---WVGNYSTTVKWNQVLHWSWESELPLECATHF--VRIKSLVDD 120

  Fly   312 TLWSEPMIYAFATAPAPPRRPPRVTYGSFYVYSSEKAMRFYWEPLEEHELNGPDFRY-------- 368
            ..:.||..::                    .:||       ||.:...:..|.|..:
Human   121 AKFPEPNFWS--------------------NWSS-------WEEVSVQDSTGQDILFVFPKDKLV 158

  Fly   369 -----------------SISEY----RINGTAVDPGLIKVESNSAMIDHWSMSAVHHFLIRSSN- 411
                             ::|.|    :|:|..:||.:.....||..            .||:..
Human   159 EEGTNVTICYVSRNIQNNVSCYLEGKQIHGEQLDPHVTAFNLNSVP------------FIRNKGT 211

  Fly   412 ------SQGLSVNATPMTIGPISNRDFKVREPRNIRSVYHPTNKSYTLSWDPPSD------QREL 464
                  |||   |.:....|.:......:.||::. |......|:...:|||.:|      ::..
Human   212 NIYCEASQG---NVSEGMKGIVLFVSKVLEEPKDF-SCETEDFKTLHCTWDPGTDTALGWSKQPS 272

  Fly   465 QNYTVF--------------WCVPKPGLQSECEGSIRFAEVASGLHHFTTSPDQLLTLHMAVSAN 515
            |:||:|              ||            :.:..:.:...::||...:..|.........
Human   273 QSYTLFESFSGEKKLCTHKNWC------------NWQITQDSQETYNFTLIAENYLRKRSVNILF 325

  Fly   516 YQSHNTGLHWAICSSDKKDDLAKMEP---SIDVATSTSLTVSWSERVCAVILAGYNLTY-CQ--- 573
            ..:|...|               |.|   :.:...:|:..::|.     |.....|.|| ||
Human   326 NLTHRVYL---------------MNPFSVNFENVNATNAIMTWK-----VHSIRNNFTYLCQIEL 370

  Fly   574 RSAGRPDNCTTVTIDRYTNKHVIQNLVPYTDYSVKMLMYSDSRVSKYSDELVNR--TGEAAPSQP 636
            ...|:......|:| :...::.:..|.|.|:|..::.....|...|:|:.....  |.|||||:.
Human   371 HGEGKMMQQYNVSI-KVNGEYFLSELEPATEYMARVRCADASHFWKWSEWSGQNFTTLEAAPSEA 434

  Fly   637 RELQLIRVTS-----DSVELAWKP--PLLANGVVRAYEGTFRSLHDNVTDTFRVSASADELVNNE 694
            .::.  |:.|     .:|.|.|||  .|.|||.:..|         ||.           :.|.:
Human   435 PDVW--RIVSLEPGNHTVTLFWKPLSKLHANGKILFY---------NVV-----------VENLD 477

  Fly   695 KPITYRLGNLTA---FTK-------YEISVRARTVYPSEPSNVILFS---------------TAI 734
            ||.:..|.::.|   .||       |:|.|.|.....:.|::||:.|               |..
Human   478 KPSSSELHSIPAPANSTKLILDRCSYQICVIANNSVGASPASVIVISADPENKEVEEERIAGTEG 542

  Fly   735 GV-----PSPPQL--YVI----NNPDQSSRLDWE--PPRT-----------PAGRIDFYEISLRD 775
            |.     |.|..:  ||:    :..|......|:  .|.|           |..|.||....|..
Human   543 GFSLSWKPQPGDVIGYVVDWCDHTQDVLGDFQWKNVGPNTTSTVISTDAFRPGVRYDFRIYGLST 607

  Fly   776 NNASCL-------TSTILPGRNLSYVMATPRCTSHNPFQLAVRAINVEQ---------------- 817
            ...:||       :..:.|..|...::.|  .|||: |.|:.:..:.|.
Human   608 KRIACLLEKKTGYSQELAPSDNPHVLVDT--LTSHS-FTLSWKDYSTESQPGFIQGYHVYLKSKA 669

  Fly   818 ---HPQLNGADAAEGAVLLMSTNGKGCEARTDALGEE----ERLQFEAYAANMTAYRLYRSDW-- 873
               ||:.      |.|||  |...:.|:.:.|...|:    :.|:.|::      |..:.:.:
Human   670 RQCHPRF------EKAVL--SDGSECCKYKIDNPEEKALIVDNLKPESF------YEFFITPFTS 720

  Fly   874 ------GIYGFICTPDTHSVKAMYQTIEVTVAILVLGVIFYLVYKKYRKMSDIGLVLPQGIMETM 932
                  ..:..:.|||.||...::..:.:...:|::.|:.||              ..|.|.||.
Human   721 AGEGPSATFTKVTTPDEHSSMLIHILLPMVFCVLLIMVMCYL--------------KSQWIKETC 771

  Fly   933 KKPIDMGGLGLGLGPDSSVSGGIVCTRVDDSPPYTPQDLPHDFSSCGSESSKLLLRTASSSGGGG 997
            ...|          ||...|..:...:..::|                   .|::...|.
Human   772 YPDI----------PDPYKSSILSLIKFKENP-------------------HLIIMNVSD----- 802

  Fly   998 CVDRDGYDDNHETGPISAVGPP----TSYLAMRHGLLVQNDRERERERDREQEREREQQQQQRES 1058
            |:          ...|..|..|    ..:|..|..|                          .|:
Human   803 CI----------PDAIEVVSKPEGTKIQFLGTRKSL--------------------------TET 831

  Fly  1059 EMDREQSCTNGYIKPTQMKSWGGNGPS---DNDHTFSVPSTAMTAPMSQPLSQIPLSGYVPVPIP 1120
            |:.:....   |:.||: |:..|.||.   :|            ...:|..|.....|:|||
Human   832 ELTKPNYL---YLLPTE-KNHSGPGPCICFEN------------LTYNQAASDSGSCGHVPV--- 877

  Fly  1121 QSRFNPAPVQPFGSPAVPSAATAAAASTFFPPAHLLNMDNYVQASDLHKLKPLVAAP-------- 1177
                         ||..||..           ..:.:.:|.::|.:.:.:..|...|
Human   878 -------------SPKAPSML-----------GLMTSPENVLKALEKNYMNSLGEIPAGETSLNY 918

  Fly  1178 LSQTGGPAFAGSSPATSPPLQLP 1200
            :||...|.|.......:.|::.|
Human   919 VSQLASPMFGDKDSLPTNPVEAP 941

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
dome	NP_523412.1	fn3	541..621	CDD:278470	18/86 (21%)
dome	NP_523412.1	FN3	633..732	CDD:238020	31/130 (24%)
OSMR	NP_001310435.1	FN3	233..>288	CDD:304408	12/55 (22%)
		FN3	335..407	CDD:214495	16/77 (21%)
		WSXWS motif	416..420		1/3 (33%)
		FN3	446..522	CDD:238020	25/95 (26%)
		fn3	540..608	CDD:278470	15/67 (22%)
		FN3	626..734	CDD:238020	22/124 (18%)
		Box 1 motif	771..779		3/17 (18%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	0	0.000