DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment dome and ptprq

DIOPT Version :9

Sequence 1:	NP_523412.1	Gene:	dome / 32976	FlyBaseID:	FBgn0043903	Length:	1282	Species:	Drosophila melanogaster
Sequence 2:	XP_021323628.1	Gene:	ptprq / 555426	ZFINID:	ZDB-GENE-050419-183	Length:	2896	Species:	Danio rerio

Alignment Length:	789	Identity:	191/789 - (24%)
Similarity:	291/789 - (36%)	Gaps:	209/789 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly   147 PP---NTVITKYNISYNTNNDWRYSNTLDCNFDSAPVVTCNLTDDNYKRFSETFYFRLSISNA-- 206
            ||   |.||..||:.|     |..:.:|:.......:|..||     ::::   ::|:|:..|
Zfish  1285 PPLLANGVILFYNVEY-----WNATQSLNQTTHMPYIVLSNL-----RKYA---HYRISVQAATQ 1336

  Fly   207 --LGHETQPI----TINH------FERLVPARPGQNLTLLNRTESSVCLSWEMPRRSNYNRGLVW 259
              :|:.|..|    |:..      |.:.||:.|.:.|.....:::.|.||||.|..:| :..|.:
Zfish  1337 VGMGNHTSEILNITTLEDGECLLCFSQTVPSSPPKFLIARKLSDTEVELSWEAPEEAN-SEILYY 1400

  Fly   260 QVRVTPQNFEPITRPSWRNHT---LTIKDTLCLTELPFAG-YNYTLRVRVRANQNNTLWSEPMIY 320
            .|||            |...|   ..:.:|..:..:...| ||.::....|......|     ||
Zfish  1401 IVRV------------WNLSTEFVANVTETSVVVSVDGPGQYNASVSSWTRLGDGGLL-----IY 1448

  Fly   321 -AFATAPAPPRRPPRVTYGSFYVYSSEKAMRFYWEPLEEHELNGPDFRYSISEYRINGTAVD--- 381
             .|:|..:.|..||:   ...|...:...:|..|.|  .:|.||....|:| .|..|.|...
Zfish  1449 ITFSTIESAPSDPPQ---DVVYTLLTISTVRLSWRP--PNEPNGIIQYYTI-YYTDNNTEYTERV 1507

  Fly   382 PGLIKVESNSAMIDHWSMSAVHHFLIRSSNSQG------LSVNATPMTIGPISNRDFKVREPRNI 440
            ||    ..:..::........:...:.||.|.|      .|:|.|.:..|         :.|.::
Zfish  1508 PG----SEHQLLLSDLQAGQDYSVWMSSSTSVGDGGLFSPSLNFTTLEDG---------QSPHSL 1559

  Fly   441 R--------------------------------SVYHPTNKSYTLSWDPPSD-------QRELQ- 465
            |                                ::|..|  :..:|||||.:       |..||
Zfish  1560 RGEAQLCTTFPTDYTSKKIALKLPSGPVHNLSATIYSST--AVVISWDPPLEPNGRVYYQLSLQE 1622

  Fly   466 --------NYTVFWCVPKPGLQSECEGSIRFAEVASGLHHFTTSP---DQLLTLHMAVSA-NYQS 518
                    |.||...:.|              .....::.||...   ..::.:..|.|| :..:
Zfish  1623 AGITHPSINRTVNMTITK--------------TTTDTIYLFTKLRKYFPYIINVTPATSAGSAVN 1673

  Fly   519 HNTGLHWAICSSDKKDDLAKMEPSIDVA----TSTSLTVSWSERVCA---VILAGYNLTYCQRSA 576
            |.|.||.      :.|:.....|.:..:    :|||:.|||...|.|   :|....||   |..:
Zfish  1674 HTTMLHL------RTDEDVPSSPPLSGSNKNLSSTSIQVSWFPPVEANGEIIEYAVNL---QGPS 1729

  Fly   577 GRPDNCTTVTIDRYTNKH-VIQNLVPYTDYSVKMLMYSDSRVSKYSDELVN-RTGEAAP-SQPRE 638
            ....|.|:.|       | |:..|.|:|.|::.:.  :.:||......::: .|.||.| |.||.
Zfish  1730 TSNKNYTSET-------HLVLSELTPFTPYNLSIA--AVTRVGTGPPVVLSLHTDEAGPMSPPRN 1785

  Fly   639 LQLIRVTSDSVELAWKPPLLANGVVRAYEGTFRSLHDNVTDTFRVSASADELVNNEKPITYRLGN 703
            |.:...|::||.|.|:|....||||:.|  .||.|..| ||:||...|:|.....|      ||.
Zfish  1786 LTIFNHTANSVWLQWEPSPEPNGVVQLY--GFRILELN-TDSFRYQNSSDASTQAE------LGG 1841

  Fly   704 LTAFTKYEISV--RARTVYPSEPSNVILFSTAIGVPSPPQLYVINNPD-QSSRLDWEPPRTPAGR 765
            ......|||||  ..|.....:.|..:||:|...|.........:..| .|..::||.|..|.|.
Zfish  1842 FKPHNSYEISVCTFTRAGNGDQYSLPVLFTTNESVSDAVGNLSCSGLDWDSVYMEWELPDHPNGE 1906

  Fly   766 IDFYEI---SLRDN-NASCLTSTI---LPGR-------------NLSYVMATPRCTSHNPFQLAV 810
            |.:|.|   .|.|. :...||.|:   |.|.             |.:.|.....|::|.|.:..|
Zfish  1907 ILYYLIRSGDLEDEAHPVVLTHTVAHTLTGLSPHAFYLITVAAVNSAGVGEEANCSAHTPPESVV 1971

  Fly   811 RAINVEQHP 819
            ....|...|
Zfish  1972 HKKGVNYVP 1980

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
dome	NP_523412.1	fn3	541..621	CDD:278470	24/87 (28%)
dome	NP_523412.1	FN3	633..732	CDD:238020	38/101 (38%)
ptprq	XP_021323628.1	fn3	209..278	CDD:306538
		FN3	301..363	CDD:328772
		FN3	382..470	CDD:238020
		FN3	475..569	CDD:238020
		FN3	723..808	CDD:238020
		FN3	829..>864	CDD:238020
		FN3	<1033..1067	CDD:238020
		FN3	1072..1161	CDD:238020
		fn3	1170..1241	CDD:306538
		fn3	1264..1340	CDD:306538	16/67 (24%)
		fn3	1368..>1410	CDD:306538	14/54 (26%)
		FN3	1460..1549	CDD:238020	22/98 (22%)
		FN3	1585..1670	CDD:214495	19/100 (19%)
		FN3	1697..1768	CDD:238020	23/82 (28%)
		FN3	1781..1872	CDD:238020	37/99 (37%)
		fn3	1878..1958	CDD:306538	19/79 (24%)
		FN3	2029..2133	CDD:238020
		FN3	2141..2235	CDD:238020
		FN3	2242..2338	CDD:238020
		UP_III_II	2354..>2491	CDD:297589
		PTPc	2599..2855	CDD:214550
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	LDO	PTHR46957
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	2.010