Protein Alignment dome and Ptprq

DIOPT Version :10

• Sequence 1: NP_523412.1
• Gene: dome / 32976
• FlyBaseID: FBgn0043903
• Length: 1282
• Species: Drosophila melanogaster
• Sequence 2: NP_075214.2
• Gene: Ptprq / 360417
• RGDID: 620779
• Length: 2302
• Species: Rattus norvegicus
• Alignment Length: 1220
• Identity: 266/1220 - (21%)
• Similarity: 429/1220 - (35%)
• Gaps: 375/1220 - (30%)

  Fly   143 NFTQP--PNTVITKYNISYNTNNDWRYSNTLDCNFDSAPVVTCNLTD--DNYKRFSETFYFRLSI 203
            :|..|  ||.:|.||.|....:|          :.::..:.|.:||.  ...|:::. :...:|.
  Rat   781 SFLPPRSPNGIIQKYTIYLKRSN----------SHEARTINTTSLTQTIGGLKKYTH-YVIEVSA 834

  Fly   204 SNALGH--ETQPITINHFERLVPARPGQNLTLLNRTESSVCLSWEMPRRSN----YNRGLVWQVR 262
            |...|.  .::||:| ..|...|..|.||.::...:..:|.|||:.|...|    |....||.
  Rat   835 STLKGEGIRSRPISI-LTEEDAPDSPPQNFSVKQLSGVTVMLSWQPPLEPNGIILYYTVYVWD-- 896

  Fly   263 VTPQNFEPITRPSWRNHTLTIKDTLCLTELPF-AGYNYTLRVRVRANQNNTLWSEPMIYAFATAP 326
                      :.|.|....| :.:|.|::|.: ..|...:....|....|   :...|..|.|..
  Rat   897 ----------KSSLRAINAT-EASLVLSDLDYNVDYGACVTASTRFGDGN---ARSSIINFRTPE 947

  Fly   327 APPRRPPRVTYGSFYVYSSEKAMRFYWEPLEEHELNGPDFRYSISEYRINGTAVDP-GLIKV--E 388
            ..|..||...:   ||..|..::..:|.|  ..:.||....||:.....:||.|.. .|::|  |
  Rat   948 GEPSDPPNDVH---YVNLSSSSIILFWTP--PVKPNGIIQYYSVYYQNTSGTFVQNFTLLQVTKE 1007

  Fly   389 SN----SAMIDHWSMSAVHHFLIRSSNSQGLSVNA-------TPMTI--GPISNRDFKVREPRNI 440
            |:    ||.|...::.:.:.|.:.:|.|.|....:       |...|  ||:.|..|:
  Rat  1008 SDNVTVSARIYRLAIFSYYTFWLTASTSVGNGNKSSDIIHVYTDQDIPEGPVGNLTFE------- 1065

  Fly   441 RSVYHPTNKSYTLSWDPPSDQRELQNYTVFWCVPKPGLQS----------ECEGSIRFAEVASGL 495
             |:   ::.:..:||:|||.    .|..||:.:.....||          ..|.||.|.:    |
  Rat  1066 -SI---SSTAIHVSWEPPSQ----PNGLVFYYLSLNLQQSPPRHMIPPLVTYENSIDFDD----L 1118

  Fly   496 HHFTTSPDQLLTLHMAVSANY-QSHNTGLHWAICSSDKKDDLAKMEPSIDV---ATSTSLTVSWS 556
            ..:|   |.:..:..:....: :::.|.||     ...::|:....|.|:.   .:|||:.:||.
  Rat  1119 EKYT---DYIFKITPSTEKGFSETYTTQLH-----IKTEEDVPDTPPIINTFKNLSSTSILLSWD 1175

  Fly   557 E--RVCAVILAGYNLTYCQRSAGRPDNCTTVTIDRYTNKHVIQNLVPYTDYSVKMLMYSDSRVSK 619
            .  :....|| ||:||.    .|...|.|.||..   |..|::.|.|:|.||    .::.:|..|
  Rat  1176 PPLKPNGAIL-GYHLTL----QGPHANHTFVTSG---NHIVLEELSPFTLYS----FFAAARTMK 1228

  Fly   620 ---YSDELVNRTGEAAP-SQPRELQLIRVTSDSVELAWKPPLLANGVVRAYEGTFRSLHDNVTDT 680
               .|..|...|.|:|| :.|:.|.||..|||.|.|.|.|..|..|:|:.|  :|: :|::.|||
  Rat  1229 GLGPSSILFFYTDESAPLAPPQNLTLINYTSDFVWLTWSPSPLPGGIVKVY--SFK-IHEHETDT 1290

  Fly   681 F---RVSA-SADELVNNEKPITYRLGNLTAFTKYEISVRARTVYPSEPSNVILFSTAIGVPSPPQ 741
            .   .:|. ..|..:...:|::....:::||||....        ::.|||:.|:|...||.
  Rat  1291 VFYKNISGLQTDAKLEGLEPVSTYSVSVSAFTKVGNG--------NQYSNVVEFTTQESVPE--- 1344

  Fly   742 LYVINNPD------QSSRLDWEPPRTPAGRIDFYEISLRDNNASCLTSTILPGRNLSYVMATPRC 800
              .:.|.:      ||..:.|:|||...|.|..|.|::..|      ||.:..|:.:|...  :.
  Rat  1345 --AVRNIECVARDWQSVSVRWDPPRKANGIIIHYMITVGGN------STKVSPRDPTYTFT--KL 1399

  Fly   801 TSHNPFQLAVRAINVEQHPQLNGADAAEGAVLLMSTN-GKGCEARTD--ALGE------------ 850
            .::..:...|||                      ||: |:|.|:|.|  .|.|
  Rat  1400 LANTSYVFEVRA----------------------STSAGEGNESRCDISTLPETVPSAPTNVAFS 1442

  Fly   851 ----------------------------------------EERLQFE----AYAANMT------- 864
                                                    ||.::.:    .|.||.|
  Rat  1443 NVQSTSATLTWTKPDTIFGYFQNYKITTQLRPQKCREWEPEECIEHQKDQYLYEANQTEETVHGL 1507

  Fly   865 -AYRLYR--------------SDWGIYGFICT------PD-----THSVKAMYQTIEVTVA--IL 901
             .:|.||              |:|     |.|      ||     .|.|......|.::.:  .:
  Rat  1508 KKFRWYRFQVAASTNVGYSNASEW-----ISTQTLPGPPDGPPENVHVVATSPFGINISWSEPAV 1567

  Fly   902 VLGVIFYLVYKKYRKMSDIGLVLPQGIMETMKKPID---------------MGGLGLGLGPDSSV 951
            :.|..|||:..|.....|..:...:...|.....|:               :|.:.... .|...
  Rat  1568 ITGPTFYLIDVKSVDDDDFNISFLKSNEENKTTEINNLEVFTRYSVVITAFVGNVSRAY-TDGKS 1631

  Fly   952 SGGIVCTRVDDSPPYTPQDLPHDFSSCGSESSKLLLRTASSSGGGG-------CVDRDGYDDN-- 1007
            |..::.|.::..|...|.::  .|.....|.:|..|.....|...|       .|.|:  ||.
  Rat  1632 SAEVIITTLESVPKDPPNNM--TFQKIPDEVTKFQLTFLPPSQPNGNIRVYQALVYRE--DDPTA 1692

  Fly  1008 ---HETGPISAVGPPTSYLAMRHGLLVQNDRERERERDREQEREREQQQQQRESEMDREQSCTNG 1069
               |....|...  .||.:||..||.
  Rat  1693 VQIHNLSIIQKT--DTSVIAMLEGLK--------------------------------------- 1716

  Fly  1070 YIKPTQMKSWGGNGPSDNDHTFSVPSTAMTAPMSQPLSQIPLSGYVPVPI-PQSRFNPAPVQPFG 1133
                      ||       ||:::...|:.:..:.|..|:.::..:..|. |:|:  |.|::
  Rat  1717 ----------GG-------HTYNISVYAINSAGAGPKVQMRITMDIKAPARPKSK--PIPIR--- 1759

  Fly  1134 SPAVPSAATAAAASTFFPPAHLLNMDNYVQASDLHKLKPLVAAPLSQTGG 1183
             .|.......:...|...|....|.|:    ..:..::.|||...:|..|
  Rat  1760 -DATGKLLVTSTTITIRMPICYYNDDH----GPIRNVQVLVAETGAQQDG 1804

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
dome	NP_523412.1	fn3	541..621	CDD:394996	27/87 (31%)
		FN3	<583..>785	CDD:442628	65/215 (30%)
		FN3	633..732	CDD:238020	32/103 (31%)
Ptprq	NP_075214.2	FN3	<28..401	CDD:442628
		FN3	58..152	CDD:238020
		FN3	400..>442	CDD:473895
		FN3	571..655	CDD:238020
		fn3	669..748	CDD:394996
		FN3	<708..1076	CDD:442628	78/338 (23%)
		FN3	763..851	CDD:238020	19/81 (23%)
		FN3	1036..1627	CDD:442628	151/681 (22%)
		FN3	1646..1735	CDD:238020	24/150 (16%)
		UP_III_II	1760..1929	CDD:471435	10/49 (20%)
		R-PTPc-Q	2034..2257	CDD:350464