DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment dome and Ptprb

DIOPT Version :9

Sequence 1:	NP_523412.1	Gene:	dome / 32976	FlyBaseID:	FBgn0043903	Length:	1282	Species:	Drosophila melanogaster
Sequence 2:	NP_001359063.1	Gene:	Ptprb / 314843	RGDID:	1305922	Length:	2000	Species:	Rattus norvegicus

Alignment Length:	1169	Identity:	209/1169 - (17%)
Similarity:	349/1169 - (29%)	Gaps:	484/1169 - (41%)

- Green bases have known domain annotations that are detailed below.

  Fly   172 DCNFDSAPV-----VTCNLTDDNYK--RFSE------------------TFYFRLSISNALG-HE 210
            :|:|.|...     ||......||:  .|||                  :.|.::|..:|.| .:
  Rat   697 ECSFSSLTPGRLYNVTITTKSGNYESHSFSEERTVPDKVQGISVSNSARSDYLKVSWVHATGDFD 761

  Fly   211 TQPITINH------------------FERLVPAR--------------------------PGQNL 231
            ...:||.:                  |.||||.|                          |.:||
  Rat   762 HYEVTIKNRDSFIQTKSIPKSENECVFARLVPGRLYSITVTTKSGQYEASEQGTGRTIPEPVKNL 826

  Fly   232 TLLNRTESSVCLSWEMPRRSNYNRGLVWQVRVTPQNFEPITRPSWRNHTLTIKDTLCLTELPFAG 296
            |||||:...:.::|.   |:|   |.|.|..|
  Rat   827 TLLNRSTEDLHVTWS---RAN---GDVDQYEV--------------------------------- 852

  Fly   297 YNYTLRVRVRANQNNTLWSEPMIYAFATAPAPPRRPPRVTYGSFYVYSSEKAMRFYWEPLEEHEL 361
                          ..|:::..::           ||        :|....|..:.:..|.
  Rat   853 --------------QLLFNDMKVF-----------PP--------IYLVNTATEYQFSALT---- 880

  Fly   362 NGPDFRYSISEYRINGTAVDPGLIKVESNSAMIDHWSMSAVHHFLIRSSNSQGLSVNATPMTIGP 426
              |...|.|....|:|....|..|                           :||:|   |.|:
  Rat   881 --PGRHYKILVLTISGDVQQPAFI---------------------------EGLTV---PSTV-- 911

  Fly   427 ISNRDFKVREPRNIRSVYHPTNKSYTLSWDPPS------------DQRELQNYTVFWCVPKPG-- 477
                       :||....:......|::|.|..            ...:::::|    :||.|
  Rat   912 -----------KNIHISANGATDRLTVTWSPGGGDVDSYVVSAFRQDEKVESHT----LPKHGSE 961

  Fly   478 -----LQSECEGSIRFAEVASGLHHFTTSPDQLLTLHMAVSANYQSHNTGLHWAICSSDKKDDLA 537
                 |::.....|....|:..|.      :|:..|...|.|:       :|..:..
  Rat   962 HTFHRLEAGATYRIAIVSVSGSLR------NQIDVLGQTVPAS-------VHGVVAD-------- 1005

  Fly   538 KMEPSIDVATSTSLTVSW------SERVCAVILA--GYNLTYCQRSAGRPDNCTTVTIDRYTNKH 594
                  :..:|.||||||      :||...::|:  |..|:.....|       ||      .:|
  Rat  1006 ------NAYSSNSLTVSWQKALGMAERYDILLLSENGVLLSNTSEPA-------TV------KQH 1051

  Fly   595 VIQNLVPYTDYSVKMLMYSDSRVSKYSDELVNRTGEAAPSQPRELQLIRVTSDSVELAWKPPLLA 659
            ..::|.|...|.:::|..|....||.    |...|...|:....|::...:|..:..:|
  Rat  1052 KFEDLTPGKKYKMQILTVSGGLFSKE----VETEGRTVPAAVTNLRITENSSRHLSFSW------ 1106

  Fly   660 NGVVRAYEGT---FRSLHDNVTDTFRVSASADELVNNEKPITYRLGNLTAFTKYEISVRARTVYP 721
                .|.||.   :.....|...|.:..|..|.||.     ::...||.....|::.:   ..:.
  Rat  1107 ----TASEGELSWYNIFLYNPDKTLQERAQVDPLVQ-----SFSFQNLLQGRMYKMVI---VTHS 1159

  Fly   722 SEPSN-VILFSTAIGVPSPPQLYVINNPDQSSR-------LDWEPPRTPAGRIDFYEISLRDNNA 778
            .|.|| ..:|...  ||:     .:|:...|:|       ..|.|   .:|..||||:.|.:.|.
  Rat  1160 GELSNESFIFGRT--VPA-----AVNHLKGSNRNMTDSLWFSWSP---ASGDFDFYELILYNPNG 1214

  Fly   779 SCLTS------------TILPGRNLSYVMAT---------------------------------- 797
            :...:            .::|||..:..:.|
  Rat  1215 TKKENWREKDVTEWRFQGLIPGRKYTLYVVTHSGDLSNKVTGEGRTAPSPPSLLSFADVANTSLA 1279

  Fly   798 ------PRCTSHNPFQL------AVRAINVEQHPQLNGADAAEGAVLLMSTNGKGCEARTDALGE 850
                  |..|.:|.|:|      |:...|    |.  .:..:||.::    ||         |..
  Rat  1280 ITWKGPPDWTDYNDFELQWLPGDALTVFN----PY--SSKKSEGRIV----NG---------LRP 1325

  Fly   851 EERLQFEAYAANMTAYRLYRSDWGIYGFI-----------CTP-----------------DTHSV 887
            ....||.....:..:::.|...  |.|.:           |.|                 |.:|:
  Rat  1326 GRSYQFSVKTVSGDSWKTYSKP--ISGSVRTKPDKIQNLHCRPQNSTAIACSWIPPDSDFDGYSI 1388

  Fly   888 ---KAMYQTIEVTVAILVLGVIFYLVYKKYRKMSDIGLVLP-QGIMETMKKPIDMGGLGLGLGPD 948
               |...|.||           |....:|.:.:.:|.:::| :..:.::|  :...|:...:..|
  Rat  1389 ECRKMDTQEIE-----------FSRKLEKEKSLLNIMMLVPHRRYLVSIK--VQSAGVTSEVVED 1440

  Fly   949 SSVSGGIVCTRVDDSPPYTPQDLPHDFSSCGSESS-KLLLRTASSSGGGGCV--------DRDGY 1004
            |::      |.:|..||..|....::.....|:|| ...:..:..|...|.|        :.|..
  Rat  1441 STI------TMIDRPPPPPPHIRVNEKDVLISKSSINFTVNCSWFSDTNGAVKYFAVVVREADSM 1499

  Fly  1005 DD-----NHETGPISAVGPPTSYLAMRHGLLVQ----NDRERERERDREQEREREQQQQQRESEM 1060
            |:     .|         |..|||..||...::    |....:.....:.:|..:....:...||
  Rat  1500 DELRPEQQH---------PLPSYLEYRHNASIRVYQTNYFASKCAESPDPDRSSKSFNIKLGGEM 1555

  Fly  1061 D--------REQSCTNGYIKP-----------TQMKSWG---GNGPSDNDHTFSVPSTAMTAPM 1102
            |        .:|...:|.:||           ||:...|   ...|..:|..||:|.|..:.|:
  Rat  1556 DSLGGKCDPSQQKFCDGPLKPHTAYRISIRAFTQLFDEGLKEFTKPLYSDTFFSMPITTESEPL 1619

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
dome	NP_523412.1	fn3	541..621	CDD:278470	23/87 (26%)
dome	NP_523412.1	FN3	633..732	CDD:238020	20/102 (20%)
Ptprb	NP_001359063.1	fn3	113..195	CDD:365830
		FN3	204..273	CDD:214495
		fn3	292..365	CDD:365830
		fn3	394..455	CDD:365830
		fn3	470..542	CDD:365830
		fn3	645..723	CDD:365830	7/25 (28%)
		fn3	733..809	CDD:365830	12/75 (16%)
		fn3	822..895	CDD:365830	25/150 (17%)
		fn3	909..982	CDD:365830	13/89 (15%)
		fn3	1009..1077	CDD:365830	22/80 (28%)
		fn3	1088..1161	CDD:365830	15/90 (17%)
		fn3	1176..1249	CDD:365830	16/75 (21%)
		fn3	1263..1341	CDD:365830	15/96 (16%)
		fn3	1357..1436	CDD:365830	14/91 (15%)
		PTP_tm	1460..1648	CDD:376280	34/169 (20%)
		R-PTPc-B	1734..1961	CDD:350465
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR46957
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.100