Protein Alignment dome and dome

DIOPT Version :10

• Sequence 1: NP_523412.1
• Gene: dome / 32976
• FlyBaseID: FBgn0043903
• Length: 1282
• Species: Drosophila melanogaster
• Sequence 2: XP_061517833.1
• Gene: dome / 1279513
• VectorBaseID: AGAMI1_012695
• Length: 1173
• Species: Anopheles gambiae
• Alignment Length: 1327
• Identity: 345/1327 - (25%)
• Similarity: 549/1327 - (41%)
• Gaps: 319/1327 - (24%)

  Fly    28 GWVIPSK-VEQLIGGDFNLSCTLNEDYFNGKSAE---DCPVEKLYFTGGGRVYRDSKHIRILNNT 88
            ||:||:: :.:.:...|:|.||||.     :|||   ......::|.|...|.|:  .::|||::
Mosquito    29 GWIIPTEPIYREVNDSFSLQCTLNM-----RSAEARWSNSSNLMFFQGDVPVPRE--QVKILNDS 86

  Fly    89 TILFSDTNAVEQEND------YHC-MCDEYVINKSKVYVGTRPLLVRDFNCLD--YDFQFMVCNF 144
            ||     ..|.::.|      |.| :.|...:....||:|.:|..|:||.|..  :| :.|.|.|
Mosquito    87 TI-----ELVVEKADPHMNFAYTCKVNDTQGVGIRSVYIGHKPREVKDFKCRAPLWD-KHMECTF 145

  Fly   145 TQPPNTVITKYNISYNTNNDWRYSNTLDCNFDSAPVVTCNL-TDD-------------NYKRFSE 195
            |..||::...|.:.:       |...:..||      ||.| |||             .|:..:|
Mosquito   146 TPDPNSMAATYELVF-------YFKPIIQNF------TCKLETDDQTNLTKCIINVDTGYRNVNE 197

  Fly   196 TFYFRLSISNALGHETQPITINHFERLVPARPGQNLTLLNRTESSVCLSW-EMPRRSNYNRGLVW 259
            .:||.|:.||.||..:|...||||:.::| .|.....:.:.|.:|..|.| :..:...::|..:.
Mosquito   198 KYYFILTASNHLGTLSQRFIINHFDVVIP-HPPIGCVIEDVTSNSAVLKWSKWYKYDGFSRNFIC 261

  Fly   260 QVRVTPQNFEPITRPSWR---------NHTLTIKDTLCLTELPFAGYNYTLRVRVRANQNNT--- 312
            :|::    ........||         ||.:.   ||.|..||:|...|.:|:|:|.|...|
Mosquito   262 EVKL----LSIFDNNVWRTVSNEGLQLNHRVY---TLPLRNLPYAATPYDVRIRMRTNSTETGSD 319

  Fly   313 LWSEPMIYAFATAPAPPRRPPRVTYGSFYVYSSEKAMRFYWEPLEEHELNG-PDFRYSISEYRIN 376
            |||......|.|.|..|..||.|..|:| ..|:|..:..||..|::.:.|. ..|.|:|:....:
Mosquito   320 LWSNHTSCLFDTLPRKPDMPPEVAIGAF-ENSNEHHLFIYWRELDDWQHNARSGFHYNITLIDQH 383

  Fly   377 GTAVDPGLIKVESNSAMID-HWSMSAVHHFLIRSSNSQGLSVNATPMTIGPISNRDFKVREPRNI 440
            |..|:    .:.:...||| |..:...:.|:|:|:|.:|:|..|:.:.   :..|..::.:| :|
Mosquito   384 GRIVE----HLNTTGGMIDRHHLVDMNYTFVIKSANPEGMSEQASKVF---VPARRHRLDKP-SI 440

  Fly   441 RSVYHPTNKSYTLSWDPPSD-QRELQNYTVFWCVPKPGLQSECEGSIRFAEVASGLHHFTTSPDQ 504
            ..:...:.| :||||.|||. ...:.:||||||.......::|.|||.|..||:....|..| |.
Mosquito   441 DKLLSDSGK-FTLSWKPPSRIHSPITSYTVFWCNTTSNSPNDCNGSINFTSVAADQTTFVLS-DV 503

  Fly   505 LLTLHMAVSANYQSHNTGLHWAICSSDKKDDLAKMEPS-IDVATSTSLTVSWSERVCAVILAGYN 568
            ..|::.||:||....::|:.||.|::..|.|:.|::.. |....|:.:.:.|......|...||.
Mosquito   504 GSTINFAVAANAGRVSSGMVWAACTATHKTDIGKLKTIWISEMDSSQIHLKWKTECVDVAHVGYM 568

  Fly   569 LTYCQRSAGR------PD---NCTTVTIDRYTNKHVIQNLVPYTDYSVKMLMYSDSRVSKYSDEL 624
            :.||..|:.|      |:   |.|..|:|.:    :::||.||..|.:::.||||:.:...|..|
Mosquito   569 IYYCSISSPRTLGCKEPEMKINVTDKTLDHF----LLENLHPYVTYKIEIAMYSDTHIGPRSVPL 629

  Fly   625 VNRTGEAAPSQPRELQLIRVTSDSVELAWKPPLLANGVVR----AYEGTFRSLHDNVTDTFRVSA 685
            ||.|.|||||.||.|...|||::|:.|.|:||...||...    .|.|.|.. ||
Mosquito   630 VNTTMEAAPSPPRNLVTERVTNNSISLHWEPPAHINGGKMFYWVFYNGQFLK-HD---------- 683

  Fly   686 SADELVNNEKPITYRLGNLTAFTKYEISVRARTVYPSEPSNVILFSTAIGVPSPPQLYVINNPDQ 750
             .:|...|   :|:.|.||.|||:|.|:|.|.||.||..:..:...|.:|.|     .||..|..
Mosquito   684 -VEEPSTN---VTFTLDNLDAFTEYNITVTAETVKPSNSTEPVHARTLVGNP-----LVIGQPST 739

  Fly   751 SSRLD------WEPPRTPAGRIDFYEISLRDNNASCLTSTILPGRNLSYVMATPRCTSH--NPFQ 807
            :|..|      |..|..|:|.::|||:.::.|..     .:...|.....:..|.|.:.  :.::
Mosquito   740 NSSNDSKLTIGWNSPSKPSGCVEFYELKVKANQI-----IVYQQRKTECQLREPICQNRDSSKYE 799

  Fly   808 LAVRAINV----------------EQHPQLNG-----------ADAAEGAVLLMSTNGKGCEART 845
            ..|||:||                ::..:||.           |:......:.|.:||   .:..
Mosquito   800 FLVRAVNVDVTGPIKTAFEELSCSDRWTELNNMWPELKRFVAHAECGTSDAIAMQSNG---YSWL 861

  Fly   846 DALGEEERLQFEAYAANMTAYRLYRSDWGIYGFICTPDTHSVKAMYQTIEVTVAILVLGVIFYLV 910
            ..|....||.:..::..:       :.|      |:.::.:..|::..:.:.:|..:  .:|...
Mosquito   862 SELPPNIRLHYGPWSEPL-------AHW------CSMESKNTLALFILVGIAIASGI--AMFSYS 911

  Fly   911 YKKYRKMSDIGLVLPQGIMET--MKKPIDMGGLGLGLGPDSSVSGGIVCT---RVDD--SPPYTP 968
            |.|.:.:..:.:::|.|:.:.  ..||   .|.|..:||     .||:.|   |||.  :...|.
Mosquito   912 YVKVKHVLQVKVIIPDGLNDITGSGKP---SGFGAVIGP-----AGIIFTEHHRVDHIITGGSTK 968

  Fly   969 QDLPHDFSSCGSESSKLLLRTASSSGG-------------------GGCVDRDGYDDNHETGPIS 1014
            :      :|...|.::.||.::|||||                   .||.:.|.
Mosquito   969 E------ASYSKEQNQCLLPSSSSSGGSIADLSSHEPRSSADYCSNSGCCEDDS----------- 1016

  Fly  1015 AVGPPTSYLAMRHGLLVQNDRERERE------RDREQEREREQQQQQRESEMDREQSCTNGYIKP 1073
                 ||:.          |:|.||:      .|..:..|...:..|..|...|  |..|..:.
Mosquito  1017 -----TSFY----------DQEAERQDLHGYSDDTTESIENSHETHQGSSTSSR--SAANDDLG- 1063

  Fly  1074 TQMKSWGGNGPSDNDHTFSVPSTAMTAPMSQ--PLSQIPL---SGYVPVPIPQSRFNPAPVQPFG 1133
               .|:|.......:|...:|.|:|....||  ..|.:|:   |||||.|:..:...|
Mosquito  1064 ---SSFGRTNLGTVNHLPIMPVTSMEGKSSQNRSSSAMPITVTSGYVPAPVVNTVKQP------- 1118

  Fly  1134 SPAVPSAATAAAASTFFPPAHLLNMDNYVQASDLHKLKPLVAAPLSQTGGPAFAGSSPATSPPLQ 1198
                                  ::.:.|:|...|:            .||        ..:|...
Mosquito  1119 ----------------------ISSNGYLQIGALN------------NGG--------MMAPLDT 1141

  Fly  1199 LPPVHAASPAAATPKMADIGYTTMEQL 1225
            :...:.|..|||.|..   ||.|.:||
Mosquito  1142 MQKSYNAKMAAAAPIS---GYVTHKQL 1165

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
dome	NP_523412.1	fn3	541..621	CDD:394996	24/89 (27%)
		FN3	<583..>785	CDD:442628	73/211 (35%)
		FN3	633..732	CDD:238020	37/102 (36%)
dome	XP_061517833.1	None