DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment dome and ptprb

DIOPT Version :9

Sequence 1:	NP_523412.1	Gene:	dome / 32976	FlyBaseID:	FBgn0043903	Length:	1282	Species:	Drosophila melanogaster
Sequence 2:	NP_001303656.1	Gene:	ptprb / 100149130	ZFINID:	ZDB-GENE-101108-3	Length:	1892	Species:	Danio rerio

Alignment Length:	1115	Identity:	215/1115 - (19%)
Similarity:	358/1115 - (32%)	Gaps:	363/1115 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly    26 DPGWVIPSKVEQL-IGGDFNLSCT------------------LNEDYFNGKSAEDCPVEKLYFTG 71
            |||.|....:|.| :.|...:|.|                  :..:...|::|::..:..|...
Zfish   288 DPGKVSDLVIENLSVRGALKISWTPPSGEWEHIRVALSNGSEVLRNQTVGRTAKEILLSGLNLL- 351

  Fly    72 GGRVYRDSKHIRI--LNNTTILFSDTN--AVEQENDYHCMCDEYVINKSKVYVGTRPLLVRDFNC 132
            .|||||.:..:..  |.||.|...:..  .|.|.:..|  .||  .:.|.::........||
Zfish   352 PGRVYRMAVSVENGGLANTVIYEGEIGLPPVSQLHVRH--SDE--TSLSALWAHAASSSSRD--- 409

  Fly   133 LDYDFQFMVCNFTQPPNTVITKYNISYNTNNDWRYSNTLDCNFDSAPVVTCNLTDDNYKRFSETF 197
                 .:::..|....:|||...|:|    .|.|     :|.|:.       ||.......:.|.
Zfish   410 -----GYIIQLFQSNTSTVIQTRNLS----RDMR-----ECTFNV-------LTPGRLYDITVTT 453

  Fly   198 YFRLSISNA-LGHETQPITINHFERLVPARPGQNLTLLNR-TESSVCLSWEMP------------ 248
            ..::..|:| |...|||:.:||            |.|.|: :..|:..|||.|
Zfish   454 TAKIIRSSATLQGRTQPLKVNH------------LKLSNKGSTDSLNASWEKPLGDLDFYHMLLL 506

  Fly   249 -----------------------RRSNYNRGLVWQV-------------RVTPQNFEPIT----- 272
                                   |....::.||..:             |..|.....||
Zfish   507 RDQQTVHNITASANTTSRLLPFLRPGALHKILVTTISGSQTSKLAEAECRTVPAAVSDITVTNSG 571

  Fly   273 ----RPSWR-------NHTLTIKD--------------TLCLTELPFAGYNYTLRVRVRAN--QN 310
                ..||:       |:.:.:||              |.|:.....:|..|::.:...:.  :|
Zfish   572 PDFLNVSWKAAEGDVDNYVVMLKDQEKIVHTLATSKATTECVFRSLVSGRLYSISIATHSGSYRN 636

  Fly   311 NTLWSEPMIYAFATAPAPPRRPPRVTYGSFYVYSS-EKAMRFYWEPLEEHELNGPDFRYSISEYR 374
            .||..|      .|.|:..:.|..       ::|: :..::.||     :..:| |:.|.:....
Zfish   637 QTLLQE------RTKPSTVQNPTA-------IHSARDDFLKLYW-----NHASG-DYDYYVVTIE 682

  Fly   375 INGTAV-DPGLIKVESNSAMID-----------------HWSM---------SAVHHFLIRSSNS 412
            .|||.: ...|.:.:|:.|..|                 |:|.         .||.:..:.....
Zfish   683 HNGTRLQSQKLNRTQSDCAFSDLVPGRLYNLTVSTWSGQHYSAVSIYGRTFPGAVGNLSLTERGG 747

  Fly   413 QGLSVNATPMTIGPISNRDFKVREPRNIRSVYHPTNKSYTLSWDPPSDQRELQNYTVFWCVPKPG 477
            ..|.|:.|... |.:.:.:.::        :::.|..|..::......:......|       ||
Zfish   748 TFLRVSWTSAP-GDVDHYELQI--------LFNDTQVSAAVNLSSAIGEHLFSALT-------PG 796

  Fly   478 -----LQSECEGSIRFAEVASGLHHFTTSPDQLLTLHMAVSANYQSHNTGLHWAICSSDKKDDLA 537
                 :.|...||.:.||:..|    .|.|.|:.::|::..
Zfish   797 RLYKIVLSTHSGSYQRAEILEG----RTVPSQVQSVHLSAG------------------------ 833

  Fly   538 KMEPSIDVATSTSLTVSWSERVCAVILAGYNLTYCQRSAGRPDNCTTVTIDRYTNKHVIQ----N 598
                    ....||.||||.  ....|..|:::..|.        |.:...|...||:.|    |
Zfish   834 --------TADGSLRVSWSS--ADGDLDFYSVSLFQE--------THLQDSRRVPKHITQAEFYN 880

  Fly   599 LVPYTDYSVKMLMYSDSRVSKYSDELVNRTGEAAPSQPRELQL-IRVTSDSVELAWKPPLLANGV 662
            |:|...|||.:...|.|:.:..:     .||...||....|:. ..:::.|:.::|.|   |.||
Zfish   881 LIPGQLYSVTVQSVSGSQTNNST-----TTGRTEPSTVTGLRADNELSTHSLLVSWNP---AVGV 937

  Fly   663 VRAYE-------GTFRSLHDNVTDTFRVSASADELVNNEKPITYRLGNLTAFTKYEISVRARTVY 720
            ...|.       ||      |:.:....:||...|..          |||...:|:..||..: .
Zfish   938 HDGYRLWLLDDGGT------NIHNASVPAASRHHLFE----------NLTPGRRYQAHVRTLS-G 985

  Fly   721 PSEPSNVILFSTAIGVPSP---PQLYVINNPDQSSRLDWEPPRTPAGRIDFYEISLRDNNASCLT 782
            .:|..:|:    |.|...|   ..|:|.:|........|   .:..|.:|.||:.|.|.:.:...
Zfish   986 TAESKDVV----AEGQTRPSAVSALHVCSNTSSDLSFCW---ASAVGWVDGYELYLYDRDETLHY 1043

  Fly   783 STILPGRNLSYVMATPRCTSHNPFQLAVRAINVEQHPQLNGADAAEGAVLLMSTNGKGCEARTDA 847
            .|.|....|.:.....:..:|....:..::..:.....: .|..|..:|..:....:|   :||:
Zfish  1044 HTTLGSDALGWSFTLLQPGTHYKMTITSKSGKLSNQSSV-WAHTAPASVPELHVENQG---QTDS 1104

  Fly   848 LGEEERLQFEAYAANMTAYRLYRSDW-----GIYGFICTPDTHSVKAMYQTIEVTVAILVLGVIF 907
            |                     ...|     |:.|:..|.|....:...:..:|....||.|.::
Zfish  1105 L---------------------LLSWTPAPGGLTGYSVTVDGREQRVGPEVTQVVFHSLVAGRLY 1148

  Fly   908 YLVYKKYRKMSDIGLVLPQGIMETMKKPIDMGGLGLGLGPDS---SVSGGIVCTR--VDDSPPYT 967
                          |...|...|.:.......|..:...|.|   |.|||.|..:  |.|:..|.
Zfish  1149 --------------LATVQTWSEDLSNSTTAVGRTVPAAPSSVSVSCSGGSVDMKWHVPDTGDYE 1199

  Fly   968 -------PQD 970
                   |||
Zfish  1200 DFEVTWFPQD 1209

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
dome	NP_523412.1	fn3	541..621	CDD:278470	22/83 (27%)
dome	NP_523412.1	FN3	633..732	CDD:238020	24/106 (23%)
ptprb	NP_001303656.1	FN3	113..199	CDD:238020
		fn3	216..276	CDD:306538
		FN3	290..366	CDD:328772	15/76 (20%)
		fn3	380..453	CDD:306538	20/100 (20%)
		fn3	561..632	CDD:306538	11/70 (16%)
		FN3	647..727	CDD:328772	16/92 (17%)
		fn3	735..808	CDD:306538	12/88 (14%)
		fn3	823..896	CDD:306538	22/114 (19%)
		fn3	911..990	CDD:306538	22/98 (22%)
		FN3	1001..1081	CDD:328772	14/82 (17%)
		fn3	1090..1154	CDD:306538	15/101 (15%)
		FN3	<1190..1246	CDD:328772	6/20 (30%)
		fn3	1263..1340	CDD:306538
		PTPc	1637..1867	CDD:238006
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR46957
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	1.100