DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment et and dome

DIOPT Version :9

Sequence 1:	NP_001245761.1	Gene:	et / 32975	FlyBaseID:	FBgn0031055	Length:	645	Species:	Drosophila melanogaster
Sequence 2:	NP_523412.1	Gene:	dome / 32976	FlyBaseID:	FBgn0043903	Length:	1282	Species:	Drosophila melanogaster

Alignment Length:	506	Identity:	125/506 - (24%)
Similarity:	200/506 - (39%)	Gaps:	85/506 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly    81 NGTVVHVDANPANEWERRYECLLDGVI--QSHVCVRVYALLNLKDFVCRDVVY-YLRCTFSRMEN 142
            |.|::..|.| |.|.|..|.|:.|..:  :|.|.|....|| ::||.|.|..: ::.|.|::..|
  Fly    87 NTTILFSDTN-AVEQENDYHCMCDEYVINKSKVYVGTRPLL-VRDFNCLDYDFQFMVCNFTQPPN 149

  Fly   143 G---------NFENKTHYQLAMGRAKPIDCRKSEDERSRGKVECSVPIDPNSRAPEWRDFRLIMS 198
            .         |..|...|      :..:||...    |...|.|::..|...|..|...|||.:|
  Fly   150 TVITKYNISYNTNNDWRY------SNTLDCNFD----SAPVVTCNLTDDNYKRFSETFYFRLSIS 204

  Fly   199 DDLGNQSKVLRLTQAEMEVLEWPRGKHNMI-QTPNQTCLEWNGPFIYPNRTFELNVQFRHSKLPN 262
            :.||::::.:.:...|..|...|.....:: :|.:..||.|..|              |.|   |
  Fly   205 NALGHETQPITINHFERLVPARPGQNLTLLNRTESSVCLSWEMP--------------RRS---N 252

  Fly   263 LSRNLTVSQMR-----------------AVSVFDQVCFGNPPEG--NQLFYVSLSRRLHGSPWSE 308
            .:|.| |.|:|                 .:::.|.:|....|..  |....|.:....:.:.|||
  Fly   253 YNRGL-VWQVRVTPQNFEPITRPSWRNHTLTIKDTLCLTELPFAGYNYTLRVRVRANQNNTLWSE 316

  Fly   309 RYPE-FELTTNASLPARPPRFLANGFSHDRAKRELKVYWLPLDELEFNGAEQTYVASTRYGTKVA 372
              |. :...|..:.|.||||.....|....:::.::.||.||:|.|.||.:..|..|.......|
  Fly   317 --PMIYAFATAPAPPRRPPRVTYGSFYVYSSEKAMRFYWEPLEEHELNGPDFRYSISEYRINGTA 379

  Fly   373 TTQG-----SMLAIFTDWDDTQPATVSVWSSNVVGRSLESSQLEVPRLSD----IRDRRIYLESY 428
            ...|     |..|:...|..:......:.|||..|.|:.::.:.:..:|:    :|:.|.....|
  Fly   380 VDPGLIKVESNSAMIDHWSMSAVHHFLIRSSNSQGLSVNATPMTIGPISNRDFKVREPRNIRSVY 444

  Fly   429 NKT--SSRLSWQGPEELGNFTGYIVYWCKLSSKVHDACDDSSSIETTYARETAYNFSGIQG---V 488
            :.|  |..|||..|.:......|.|:||.....:...|:  .||.........::|:....   .
  Fly   445 HPTNKSYTLSWDPPSDQRELQNYTVFWCVPKPGLQSECE--GSIRFAEVASGLHHFTTSPDQLLT 507

  Fly   489 IRMAVAANYSDGLTTGMRWWSGDSEVPEKPKILRYVEGTIALLVLGSLVLA 539
            :.|||:|||... .||:.|....|   :|...|..:|.:|.:....||.::
  Fly   508 LHMAVSANYQSH-NTGLHWAICSS---DKKDDLAKMEPSIDVATSTSLTVS 554

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
et	NP_001245761.1	None
dome	NP_523412.1	fn3	541..621	CDD:278470	3/14 (21%)
dome	NP_523412.1	FN3	633..732	CDD:238020
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0016893
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	2	1.910