DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Zw and G6PD1

DIOPT Version :9

Sequence 1:	NP_523411.1	Gene:	Zw / 32974	FlyBaseID:	FBgn0004057	Length:	524	Species:	Drosophila melanogaster
Sequence 2:	NP_198428.1	Gene:	G6PD1 / 833559	AraportID:	AT5G35790	Length:	576	Species:	Arabidopsis thaliana

Alignment Length:	522	Identity:	229/522 - (43%)
Similarity:	327/522 - (62%)	Gaps:	24/522 - (4%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 EDHTALDLI------IKSLK-SPTMVCEGTHFDGKIPHTFVIFGASGDLAKKKIYPTLWWLYRDD 63
            |.|:.||..      ..||: |...:.|.....|:...:..:.|||||||||||:|.|:.|:.:.
plant    54 EKHSQLDTSNGCATNFASLQDSGDQLTEEHVTKGESTLSITVVGASGDLAKKKIFPALFALFYEG 118

  Fly    64 LLPKPTKFCGYARSMLTVDSIKEQCLPYM--KVQPHEQ--KKYEEFWALNEYVSGRYDGRTGFEL 124
            .||:.....||||:.||.:.:::.....:  ::...|:  .|.|:|.....|.||:|:....|..
plant   119 CLPQDFSVFGYARTKLTHEELRDMISSTLTCRIDQREKCGDKMEQFLKRCFYHSGQYNSEEDFAE 183

  Fly   125 LNQQLEIMENKNKANRIFYLALPPSVFEEVTVNIKQICMSVCGWNRVIIEKPFGRDDASSQALSD 189
            ||::|:..|....:||::||::||::|.:|.........|..||.|||:|||||||..||..|:.
plant   184 LNKKLKEKEAGKISNRLYYLSIPPNIFVDVVRCASLRASSENGWTRVIVEKPFGRDSESSGELTR 248

  Fly   190 HLAGLFQEDQLYRIDHYLGKEMVQNLMTIRFGNKILSSTWNRENIASVLITFKEPFGTQGRGGYF 254
            .|.....|:|::|||||||||:|:||..:||.|.:....|:|..|.:|.:.|.|.|||:||||||
plant   249 CLKQYLTEEQIFRIDHYLGKELVENLSVLRFSNLVFEPLWSRNYIRNVQLIFSEDFGTEGRGGYF 313

  Fly   255 DEFGIIRDVMQNHLLQILSLVAMEKPVSCHPDDIRDEKVKVLKSIEALTLDDMVLGQYLGNPQGT 319
            |::|||||:|||||||||:|.|||.|||...:|||.||||||:|::.|.|:|:|:|||.|:.:|
plant   314 DQYGIIRDIMQNHLLQILALFAMETPVSLDAEDIRSEKVKVLRSMKPLRLEDVVVGQYKGHNKG- 377

  Fly   320 NDDART--GYVEDPTVSNDSNTPTYALGVLKINNERWQGVPFILRCGKALNERKAEVRIQYQDVP 382
               .:|  ||.:||||.|.|.|||:|...:.|||.||.||||:::.||||:.|.||:|:|::.||
plant   378 ---GKTYPGYTDDPTVPNHSLTPTFAAAAMFINNARWDGVPFLMKAGKALHTRGAEIRVQFRHVP 439

  Fly   383 GDIFEG------NTKRNELVIRVQPGEALYFKMMTKSPGITFDIEETELDLTYEHRYKDSYLPDA 441
            |::::.      :...|||||||||.|.:|.::..|.||:...::.::|:|.|..||... :|||
plant   440 GNLYKKSFATNLDNATNELVIRVQPDEGIYLRINNKVPGLGMRLDRSDLNLLYRSRYPRE-IPDA 503

  Fly   442 YERLILDVFCGSQMHFVRSDELREAWRIFTPILHQIEKEHIRPITYQYGSRGPKEADRKCEENNF 506
            ||||:||...|.:..|:|||||..||.:|||.|.::|::.|.|..|.||||||..|.....:.|.
plant   504 YERLLLDAIEGERRLFIRSDELDAAWDLFTPALKELEEKKIIPELYPYGSRGPVGAHYLASKYNV 568

  Fly   507 KY 508
            ::
plant   569 RW 570

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Zw	NP_523411.1	zwf	35..498	CDD:273312	218/474 (46%)
		G6PD_N	39..213	CDD:278882	71/177 (40%)
		G6PD_C	216..508	CDD:280876	146/299 (49%)
G6PD1	NP_198428.1	PLN02640	1..575	CDD:215344	229/522 (44%)
		G6PD_N	95..271	CDD:278882	71/175 (41%)
		G6PD_C	276..570	CDD:280876	146/298 (49%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	149	1.000	Domainoid score	I1422
eggNOG	1	0.900	-	-		E1_COG0364
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG62474
OrthoDB	1	1.010	-	-		D383995at2759
OrthoFinder	1	1.000	-	-		FOG0001006
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100726
Panther	1	1.100	-	-	O	PTHR23429
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X665
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	9	8.830