DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Zw and G6PD2

DIOPT Version :9

Sequence 1:	NP_523411.1	Gene:	Zw / 32974	FlyBaseID:	FBgn0004057	Length:	524	Species:	Drosophila melanogaster
Sequence 2:	NP_196815.2	Gene:	G6PD2 / 831150	AraportID:	AT5G13110	Length:	596	Species:	Arabidopsis thaliana

Alignment Length:	509	Identity:	228/509 - (44%)
Similarity:	318/509 - (62%)	Gaps:	20/509 - (3%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 ATQKEDHTAL----DLIIKSLKSPTMVCEGTHFDGKIPHT--FVIFGASGDLAKKKIYPTLWWLY 60
            :...|..|:|    |.::.:| |......|...||:...|  ..:.|||||||||||:|.|:.||
plant    71 SNSSESKTSLKGLKDEVLSAL-SQEAAKVGVESDGQSQSTVSITVVGASGDLAKKKIFPALFALY 134

  Fly    61 RDDLLPKPTKFCGYARSMLTVDSIKEQCLPYMKVQPHEQ----KKYEEFWALNEYVSGRYDGRTG 121
            .:..||:.....||:||.:|...::......:..:..::    :|.|||.....|.||:||.:..
plant   135 YEGCLPEHFTIFGYSRSKMTDVELRNMVSKTLTCRIDKRANCGEKMEEFLKRCFYHSGQYDSQEH 199

  Fly   122 FELLNQQLEIMENKNKANRIFYLALPPSVFEEVTVNIKQICMSVCGWNRVIIEKPFGRDDASSQA 186
            |..|:::|:..|....:||:|||::||::|.:..........||.||.|||:|||||||..:|.|
plant   200 FTELDKKLKEHEAGRISNRLFYLSIPPNIFVDAVKCASTSASSVNGWTRVIVEKPFGRDSETSAA 264

  Fly   187 LSDHLAGLFQEDQLYRIDHYLGKEMVQNLMTIRFGNKILSSTWNRENIASVLITFKEPFGTQGRG 251
            |:..|....:|||::|||||||||:|:||..:||.|.|....|:|:.|.:|...|.|.|||:|||
plant   265 LTKSLKQYLEEDQIFRIDHYLGKELVENLSVLRFSNLIFEPLWSRQYIRNVQFIFSEDFGTEGRG 329

  Fly   252 GYFDEFGIIRDVMQNHLLQILSLVAMEKPVSCHPDDIRDEKVKVLKSIEALTLDDMVLGQYLGNP 316
            ||||.:|||||:|||||||||:|.|||.|||...:|||:||||||:|:..:.::|:|:|||..:.
plant   330 GYFDNYGIIRDIMQNHLLQILALFAMETPVSLDAEDIRNEKVKVLRSMRPIRVEDVVIGQYKSHT 394

  Fly   317 QGTNDDARTGYVEDPTVSNDSNTPTYALGVLKINNERWQGVPFILRCGKALNERKAEVRIQYQDV 381
            :|  ......|.:|.||...|.|||:|...|.|:|.||.||||:::.||||:.|.||:|:|::.|
plant   395 KG--GVTYPAYTDDKTVPKGSLTPTFAAAALFIDNARWDGVPFLMKAGKALHTRSAEIRVQFRHV 457

  Fly   382 PGDIFEGNT------KRNELVIRVQPGEALYFKMMTKSPGITFDIEETELDLTYEHRYKDSYLPD 440
            ||:::..||      ..|||||||||.||:|.|:..|.||:...::.:.|:|.|..||... :||
plant   458 PGNLYNRNTGSDLDQATNELVIRVQPDEAIYLKINNKVPGLGMRLDRSNLNLLYSARYSKE-IPD 521

  Fly   441 AYERLILDVFCGSQMHFVRSDELREAWRIFTPILHQIEKEHIRPITYQYGSRGP 494
            |||||:||...|.:..|:|||||..||.:|||:|.:||::...|..|.||||||
plant   522 AYERLLLDAIEGERRLFIRSDELDAAWSLFTPLLKEIEEKKRIPEYYPYGSRGP 575

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Zw	NP_523411.1	zwf	35..498	CDD:273312	219/472 (46%)
		G6PD_N	39..213	CDD:278882	73/177 (41%)
		G6PD_C	216..508	CDD:280876	142/285 (50%)
G6PD2	NP_196815.2	PLN02333	1..596	CDD:215191	228/509 (45%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	149	1.000	Domainoid score	I1422
eggNOG	1	0.900	-	-		E1_COG0364
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG62474
OrthoDB	1	1.010	-	-		D383995at2759
OrthoFinder	1	1.000	-	-		FOG0001006
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100726
Panther	1	1.100	-	-	O	PTHR23429
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X665
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	10	9.830