DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Zw and g6pd

DIOPT Version :9

Sequence 1:	NP_523411.1	Gene:	Zw / 32974	FlyBaseID:	FBgn0004057	Length:	524	Species:	Drosophila melanogaster
Sequence 2:	XP_005162067.1	Gene:	g6pd / 570579	ZFINID:	ZDB-GENE-070508-4	Length:	534	Species:	Danio rerio

Alignment Length:	489	Identity:	322/489 - (65%)
Similarity:	382/489 - (78%)	Gaps:	1/489 - (0%)

- Green bases have known domain annotations that are detailed below.

  Fly    26 EGTHFDGKIPHTFVIFGASGDLAKKKIYPTLWWLYRDDLLPKPTKFCGYARSMLTVDSIKEQCLP 90
            :.|.|.....|.|:|.||||||||||||||||||:||.|||:.|.|.|:|||.||||:|:..|:|
Zfish    41 DDTAFHQSDVHIFIIMGASGDLAKKKIYPTLWWLFRDGLLPEQTYFVGFARSDLTVDAIRIACMP 105

  Fly    91 YMKVQPHEQKKYEEFWALNEYVSGRYDGRTGFELLNQQLEIMENKNKANRIFYLALPPSVFEEVT 155
            ||||..:|.::...|::.|.|:||:|...:.|..||..|..:....:|||:|||||||||:.:||
Zfish   106 YMKVVDNEAERLAAFFSRNSYISGKYVEESSFSDLNTHLLSLPGGAEANRLFYLALPPSVYHDVT 170

  Fly   156 VNIKQICMSVCGWNRVIIEKPFGRDDASSQALSDHLAGLFQEDQLYRIDHYLGKEMVQNLMTIRF 220
            .|||..|||..||||||:|||||||..||:.||.||:.||.|:|:||||||||||||||||.:||
Zfish   171 KNIKHQCMSTKGWNRVIVEKPFGRDLQSSEELSSHLSSLFTEEQIYRIDHYLGKEMVQNLMVLRF 235

  Fly   221 GNKILSSTWNRENIASVLITFKEPFGTQGRGGYFDEFGIIRDVMQNHLLQILSLVAMEKPVSCHP 285
            ||:|....|||:::|.|::||||||||||||||||:||||||||||||||:|||||||||.|...
Zfish   236 GNRIFGPIWNRDSVACVVLTFKEPFGTQGRGGYFDDFGIIRDVMQNHLLQMLSLVAMEKPASTSS 300

  Fly   286 DDIRDEKVKVLKSIEALTLDDMVLGQYLGNPQGTNDDARTGYVEDPTVSNDSNTPTYALGVLKIN 350
            ||:|||||||||.||.:||.|:|||||:|:|.| ..:|:.||::|.||...|...|:|..||.:.
Zfish   301 DDVRDEKVKVLKCIEPVTLSDVVLGQYVGDPDG-EGEAKLGYLDDKTVPKGSTQATFATAVLYVK 364

  Fly   351 NERWQGVPFILRCGKALNERKAEVRIQYQDVPGDIFEGNTKRNELVIRVQPGEALYFKMMTKSPG 415
            ||||.||||||||||||||||||||:|:.|||||||....:|||||:||||.||:|.|||:|.||
Zfish   365 NERWDGVPFILRCGKALNERKAEVRLQFTDVPGDIFSSQCRRNELVVRVQPNEAIYAKMMSKKPG 429

  Fly   416 ITFDIEETELDLTYEHRYKDSYLPDAYERLILDVFCGSQMHFVRSDELREAWRIFTPILHQIEKE 480
            :.|..|||||||||..||:|..|||||||||||||||||||||||||||||||||||:|||||.|
Zfish   430 VYFSPEETELDLTYHSRYRDVKLPDAYERLILDVFCGSQMHFVRSDELREAWRIFTPLLHQIESE 494

  Fly   481 HIRPITYQYGSRGPKEADRKCEENNFKYSGSYKW 514
            ...||.|:||||||.|||...::..|:|.|:|||
Zfish   495 KTPPIKYKYGSRGPAEADELVQKVGFRYEGTYKW 528

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Zw	NP_523411.1	zwf	35..498	CDD:273312	312/462 (68%)
		G6PD_N	39..213	CDD:278882	106/173 (61%)
		G6PD_C	216..508	CDD:280876	203/291 (70%)
g6pd	XP_005162067.1	G6PD_C	48..534	CDD:332184	320/482 (66%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170574797
Domainoid	1	1.000	423	1.000	Domainoid score	I602
eggNOG	1	0.900	-	-		E1_COG0364
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H37906
Inparanoid	1	1.050	664	1.000	Inparanoid score	I732
OMA	1	1.010	-	-		QHG62474
OrthoDB	1	1.010	-	-		D205418at33208
OrthoFinder	1	1.000	-	-		FOG0001006
OrthoInspector	1	1.000	-	-		otm24887
orthoMCL	1	0.900	-	-		OOG6_100726
Panther	1	1.100	-	-	LDO	PTHR23429
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R465
SonicParanoid	1	1.000	-	-		X665
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	16	15.890