DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Zw and h6pd

DIOPT Version :9

Sequence 1:	NP_523411.1	Gene:	Zw / 32974	FlyBaseID:	FBgn0004057	Length:	524	Species:	Drosophila melanogaster
Sequence 2:	XP_021332932.1	Gene:	h6pd / 569348	ZFINID:	ZDB-GENE-110408-60	Length:	791	Species:	Danio rerio

Alignment Length:	538	Identity:	157/538 - (29%)
Similarity:	260/538 - (48%)	Gaps:	81/538 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly    37 TFVIFGASGDLAKKKIYPTLWWLYRDDLLPKPTKFCGYARSMLTVDS--------IKE-QCLPYM 92
            |.|:.|.:||||:|.::...:.||.|. :.|...|..|...:...:.        :|| .|.|.:
Zfish    34 TVVVVGGTGDLARKYLWQGFFQLYADQ-VGKGHSFSFYGGGLSPAEKGTPVLFGILKELACPPEL 97

  Fly    93 KVQPHEQKKYEEFWALNEYVSGRYDGRTG--FELLNQQLEI---MENKNKANRIFYLALPPSVFE 152
            ..:.....| |:|..|:.|    :..:|.  :|.|.||::.   .|:..:|.|:|||::|...:.
Zfish    98 TAERCALVK-EQFLHLSRY----HQLKTAEDYEKLCQQIKQQVGQESMTEAGRLFYLSVPAFAYA 157

  Fly   153 EVTVNIKQICMSVC-GWNRVIIEKPFGRDDASSQALSDHLAGLFQEDQLYRIDHYLGKEMVQNLM 216
            |:...|...|.... .|.||::|||||.|.||:|.|...|:|..:|:::|||||||||::|..::
Zfish   158 EIAERINNTCRPPSDAWLRVVLEKPFGHDFASAQLLDKKLSGQLKEEEMYRIDHYLGKQVVSKIL 222

  Fly   217 TIRFGN-KILSSTWNRENIASVLITFKEPFGTQGRGGYFDEFGIIRDVMQNHLLQILSLVAMEKP 280
            ..|..| |:|...||:.:|..:.|..||....:||..::|::|:||||:||||.::::|:.|..|
Zfish   223 PFRKENKKLLDPIWNKHHIERIEIVLKETLDAKGRIQFYDQYGVIRDVLQNHLTEVMTLMLMNLP 287

  Fly   281 VS-CHPDDIRDEKVKVLKSIEALTLDDMVLGQYLGNPQGTNDDARTGYVE---DPTVSNDSNTPT 341
            .: .:..:|...|:..|.|::.:...:.|:|||         .|..|.|:   :.|....|.|||
Zfish   288 ANLSNSKEILLNKLHFLASLQHIDNSNAVVGQY---------QAYNGEVQAELNKTKDYFSLTPT 343

  Fly   342 YALGVLKINNERWQGVPFILRCGKALNERKAEVRIQYQDVPGDIF---EGNT---KRNELVIRVQ 400
            :|..|:.::|.:::|:|..:..||||:||.:..|:.::   .|:|   :.|.   |..:::..:.
Zfish   344 FAGVVIHVDNAQYEGIPIFMTSGKALDERVSYARVLFK---SDVFCVQDPNNVQCKSKQIIFYLG 405

  Fly   401 PGEALYFKMMTKSPGITFDI-------EETE------LDLTYEHRYKDSYLP--DAYERLILDVF 450
            .|...|..::.....:..:|       |.||      |.|.....|..|.:.  :||..||..||
Zfish   406 HGNLQYPSILVSKNLLKPEIVSSGDWKEVTEYKEVNLLGLPLSDYYIQSPVAPREAYGELISHVF 470

  Fly   451 CGSQMHFVRSDELREAWRIFTPILHQIEKEHIRPITYQYG----------SRGPKEA-------- 497
            .|.:..|:.::.|..:|..:||:|..:  .|:.|..|..|          .||.:.|
Zfish   471 FGRKDSFISAEGLLASWAFWTPLLESL--SHVYPRIYPGGVSNGNLLNFQLRGHQIAFSHEAVVN 533

  Fly   498 --DRKCEENNFKYSGSYK 513
              :|..|||.....|.|:
Zfish   534 VINRGAEENFQVMQGKYR 551

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Zw	NP_523411.1	zwf	35..498	CDD:273312	151/521 (29%)
		G6PD_N	39..213	CDD:278882	62/188 (33%)
		G6PD_C	216..508	CDD:280876	91/337 (27%)
h6pd	XP_021332932.1	G6PD_C	43..508	CDD:332184	143/484 (30%)
h6pd	XP_021332932.1	6PGL	561..784	CDD:238694
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0364
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D205418at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	2.820