DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Zw and CG7140

DIOPT Version :9

Sequence 1:	NP_523411.1	Gene:	Zw / 32974	FlyBaseID:	FBgn0004057	Length:	524	Species:	Drosophila melanogaster
Sequence 2:	NP_649376.3	Gene:	CG7140 / 40445	FlyBaseID:	FBgn0037147	Length:	533	Species:	Drosophila melanogaster

Alignment Length:	496	Identity:	216/496 - (43%)
Similarity:	310/496 - (62%)	Gaps:	21/496 - (4%)

- Green bases have known domain annotations that are detailed below.

  Fly    35 PH-----TFVIFGASGDLAKKKIYPTLWWLYRDDLLPKPTKFCGYARSMLTVDSIKEQCLPYMKV 94
            ||     :.|:|||||.|||||::|.||.|:|::.||:.||...:.||.|...:.:.|.||||::
  Fly     6 PHNEEAYSIVVFGASGGLAKKKVFPALWALFRENRLPQGTKIFTFTRSPLQTKTYRLQILPYMEL 70

  Fly    95 QPH-EQKKYEEFWALNEYVSGRYDGRTGFELLNQQL---EIMENKNKANRIFYLALPPSVFEEVT 155
            ..| :.|||..||.....|.|.||....:..|.:.:   |...|:.:|||||||||||.||::||
  Fly    71 DKHRDPKKYNLFWTTVHCVQGEYDKPENYVALTEAMVHQETKHNQVRANRIFYLALPPIVFDQVT 135

  Fly   156 VNIKQICMSVCGWNRVIIEKPFGRDDASSQALSDHLAGLFQEDQLYRIDHYLGKEMVQNLMTIRF 220
            :|:.:.|.|..||||:|:||||.|||.|.:|....|...|:|.|:|.:||.|.::::||...:|:
  Fly   136 LNVSRKCSSTTGWNRIIVEKPFARDDISYKAFQTSLCNCFRESQIYLMDHLLSRQVMQNFFALRY 200

  Fly   221 GNKILSSTWNRENIASVLITFK-EPFGTQGRGGYFDEFGIIRDVMQNHLLQILSLVAMEKPVSCH 284
            .|.:.:.|.|..::|:|:|:.| |...:..|..||::||||||:|.||::|:|:::||::|.:..
  Fly   201 SNHLWAETLNHRHVAAVMISIKCELPVSVNRADYFNQFGIIRDLMTNHMIQMLAMLAMDQPYANT 265

  Fly   285 PDDIRDEKVKVLKSIEALTLDDMVLGQYLGNPQGTNDDARTGYVEDPTVSNDSNTPTYALGVLKI 349
            .||:|.|::|||:.:....:.|:||.||..|.:.| |.|:.||.|...:..||.|||:||.||.|
  Fly   266 ADDLRAERLKVLRQVLTPNIGDVVLAQYRNNRRET-DPAKCGYTEHTYIPKDSFTPTFALVVLHI 329

  Fly   350 NNERWQGVPFILRCGKALNERKAEVRIQYQDVPGDIFEGNTK--RNELVIRVQPGEALYFKMMTK 412
            ||.||.|||||||.|||||:.|:||||||:.|..|.|..::.  |||||:|..|.|.::.:|..|
  Fly   330 NNRRWTGVPFILRAGKALNDTKSEVRIQYKPVDCDTFHSDSTDIRNELVLRSFPTEEVFMRMRLK 394

  Fly   413 SPGITFDIEETELDLTYEHRYKDSYLPDAYERL---ILDVFCGSQMHFVRSDELREAWRIFTPIL 474
            ..|....:.|:|::|..:.|.     |...:.|   :|:||.|.|..|:||||..|.||||:|:|
  Fly   395 RQGEDICLRESEINLRVDDRG-----PKGLQGLPGYLLNVFQGDQTLFMRSDEQCEIWRIFSPVL 454

  Fly   475 HQIEKEHIRPITYQYGSRGPKEADRKCEENNFKYSGSYKWH 515
            ..|:.:..||:.|.:|||||..|.||.|...|.:..:.:||
  Fly   455 ATIDSDRPRPLHYDFGSRGPLLAYRKAERAGFVFFATDEWH 495

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Zw	NP_523411.1	zwf	35..498	CDD:273312	209/477 (44%)
		G6PD_N	39..213	CDD:278882	81/177 (46%)
		G6PD_C	216..508	CDD:280876	129/297 (43%)
CG7140	NP_649376.3	PTZ00309	5..497	CDD:240353	216/496 (44%)
		G6PD_N	15..193	CDD:278882	81/177 (46%)
		G6PD_C	197..488	CDD:280876	129/296 (44%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45439825
Domainoid	1	1.000	149	1.000	Domainoid score	I1422
eggNOG	1	0.900	-	-		E1_COG0364
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	269	1.000	Inparanoid score	I109
Isobase	1	0.950	-	0	Normalized mean entropy	S501
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D19303at7147
OrthoFinder	1	1.000	-	-		FOG0001006
OrthoInspector	1	1.000	-	-		otm51347
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR23429
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X665
	11	10.850