DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Zw and zwf1

DIOPT Version :9

Sequence 1:	NP_523411.1	Gene:	Zw / 32974	FlyBaseID:	FBgn0004057	Length:	524	Species:	Drosophila melanogaster
Sequence 2:	NP_593344.2	Gene:	zwf1 / 2543200	PomBaseID:	SPAC3A12.18	Length:	500	Species:	Schizosaccharomyces pombe

Alignment Length:	461	Identity:	220/461 - (47%)
Similarity:	298/461 - (64%)	Gaps:	9/461 - (1%)

- Green bases have known domain annotations that are detailed below.

  Fly    39 VIFGASGDLAKKKIYPTLWWLYRDDLLPKPTKFCGYARSMLTVDSIKEQCLPYMKVQPHE---QK 100
            |:|||||||:|||.:|.|:.|:.:..|||..:..|||||.:..:...::....:|:...:   ::
pombe    15 VVFGASGDLSKKKTFPALFSLFSEGRLPKDIRIVGYARSKIEHEDFLDRITQNIKIDEEDSQAKE 79

  Fly   101 KYEEFWALNEYVSGRYDGRTGFELLNQQL-EIMENKNKANRIFYLALPPSVFEEVTVNIKQICMS 164
            |.|||.....|..|.||....||.||..| |...:::..||||||||||.||..|..|:|:.|:.
pombe    80 KLEEFKKRCSYYRGSYDKPEDFEGLNSHLCEREGDRSTHNRIFYLALPPDVFVSVATNLKKKCVP 144

  Fly   165 VCGWNRVIIEKPFGRDDASSQALSDHLAGLFQEDQLYRIDHYLGKEMVQNLMTIRFGNKILSSTW 229
            ..|..|::||||||.|..|:|.|...||.||.|.::|||||||||||||||:.:||.|.::|..|
pombe   145 EKGIARLVIEKPFGVDLKSAQELQSQLAPLFDEKEIYRIDHYLGKEMVQNLVHLRFCNPVISHLW 209

  Fly   230 NRENIASVLITFKEPFGTQGRGGYFDEFGIIRDVMQNHLLQILSLVAMEKPVSCHPDDIRDEKVK 294
            ::.:|:||.||||||.||:|||||||...|:||::||||:|||:|:.||.|.:...||:||||||
pombe   210 DKNSISSVQITFKEPIGTEGRGGYFDSSTIVRDIVQNHLVQILTLLTMETPTTFSADDLRDEKVK 274

  Fly   295 VLKSIEALTLDDMVLGQYLGNPQGTNDDARTGYVEDPTVSNDSNTPTYALGVLKINNERWQGVPF 359
            ||:......|.|:|||||:    .:.|..:.||::|.||...|..|||:.....|:.|||:||||
pombe   275 VLRRTRLGDLKDIVLGQYV----KSKDGKKPGYLDDETVPKGSRCPTYSAIPCFIDTERWRGVPF 335

  Fly   360 ILRCGKALNERKAEVRIQYQDVPGDIFEGNTKRNELVIRVQPGEALYFKMMTKSPGITFDIEETE 424
            :|:.|||::..|.|:|:|::.....:|: :...|||||||||.||:||||..|.||::.....|:
pombe   336 LLKAGKAMDIGKVEIRVQFKAAANGLFK-DAYHNELVIRVQPDEAIYFKMNIKQPGLSEAPLLTD 399

  Fly   425 LDLTYEHRYKDSYLPDAYERLILDVFCGSQMHFVRSDELREAWRIFTPILHQIEKEHIRPITYQY 489
            |||||..|:|:..|.:|||.|.||.|.|.|..|.|.|||..||.:..|:|..:|:|...|..|:|
pombe   400 LDLTYSRRFKNMKLHEAYEALFLDAFAGDQSRFARIDELECAWSLVDPLLKYMEEEKPVPEPYEY 464

  Fly   490 GSRGPK 495
            ||.||:
pombe   465 GSDGPE 470

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Zw	NP_523411.1	zwf	35..498	CDD:273312	220/461 (48%)
		G6PD_N	39..213	CDD:278882	81/177 (46%)
		G6PD_C	216..508	CDD:280876	135/280 (48%)
zwf1	NP_593344.2	Zwf	7..486	CDD:223441	220/461 (48%)
		G6PD_N	15..193	CDD:278882	81/177 (46%)
		G6PD_C	198..483	CDD:280876	135/278 (49%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	265	1.000	Domainoid score	I353
eggNOG	1	0.900	-	-		E1_COG0364
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H37906
Inparanoid	1	1.050	413	1.000	Inparanoid score	I359
OMA	1	1.010	-	-		QHG62474
OrthoFinder	1	1.000	-	-		FOG0001006
OrthoInspector	1	1.000	-	-		oto100630
orthoMCL	1	0.900	-	-		OOG6_100726
Panther	1	1.100	-	-	LDO	PTHR23429
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R465
SonicParanoid	1	1.000	-	-		X665
TreeFam	1	0.960	-	-
	14	13.860