DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Zw and G6pd

DIOPT Version :9

Sequence 1:	NP_523411.1	Gene:	Zw / 32974	FlyBaseID:	FBgn0004057	Length:	524	Species:	Drosophila melanogaster
Sequence 2:	NP_058702.1	Gene:	G6pd / 24377	RGDID:	2645	Length:	515	Species:	Rattus norvegicus

Alignment Length:	503	Identity:	325/503 - (64%)
Similarity:	389/503 - (77%)	Gaps:	9/503 - (1%)

- Green bases have known domain annotations that are detailed below.

  Fly    20 SPTMVC--------EGTHFDGKIPHTFVIFGASGDLAKKKIYPTLWWLYRDDLLPKPTKFCGYAR 76
            |.|.||        :|..|.....|.|:|.||||||||||||||:|||:||.|||:.|...||||
  Rat     8 SRTQVCGILREELYQGDAFHQADTHIFIIMGASGDLAKKKIYPTIWWLFRDGLLPEDTFIVGYAR 72

  Fly    77 SMLTVDSIKEQCLPYMKVQPHEQKKYEEFWALNEYVSGRYDGRTGFELLNQQLEIMENKNKANRI 141
            |.||||.|::|..|:.||.|.|:.|.|||:|.|.||:|:||....::.||..:..:....:|||:
  Rat    73 SRLTVDDIRKQSEPFFKVTPEERPKLEEFFARNSYVAGQYDDPASYKHLNSHMNALHQGMQANRL 137

  Fly   142 FYLALPPSVFEEVTVNIKQICMSVCGWNRVIIEKPFGRDDASSQALSDHLAGLFQEDQLYRIDHY 206
            |||||||:|:|.||.||::||||..||||:|:|||||||..||..||:|::.||:|||:||||||
  Rat   138 FYLALPPTVYEAVTKNIQEICMSQTGWNRIIVEKPFGRDLQSSNQLSNHISSLFREDQIYRIDHY 202

  Fly   207 LGKEMVQNLMTIRFGNKILSSTWNRENIASVLITFKEPFGTQGRGGYFDEFGIIRDVMQNHLLQI 271
            ||||||||||.:||.|:|....|||:|||.|::||||||||:||||||||||||||||||||||:
  Rat   203 LGKEMVQNLMVLRFANRIFGPIWNRDNIACVILTFKEPFGTEGRGGYFDEFGIIRDVMQNHLLQM 267

  Fly   272 LSLVAMEKPVSCHPDDIRDEKVKVLKSIEALTLDDMVLGQYLGNPQGTNDDARTGYVEDPTVSND 336
            |.|||||||.|...||:|||||||||.|..:..|::|||||:|||.| ..:|..||::||||.:.
  Rat   268 LCLVAMEKPASTDSDDVRDEKVKVLKCISEVETDNVVLGQYVGNPSG-EGEATNGYLDDPTVPHG 331

  Fly   337 SNTPTYALGVLKINNERWQGVPFILRCGKALNERKAEVRIQYQDVPGDIFEGNTKRNELVIRVQP 401
            |.|.|:|..||.:.||||.||||||||||||||||||||:|::||.||||....|||||||||||
  Rat   332 STTATFAAAVLYVENERWDGVPFILRCGKALNERKAEVRLQFRDVAGDIFHQQCKRNELVIRVQP 396

  Fly   402 GEALYFKMMTKSPGITFDIEETELDLTYEHRYKDSYLPDAYERLILDVFCGSQMHFVRSDELREA 466
            .||:|.|||||.||:.|:.||:||||||.:|||:..|||||||||||||||||||||||||||||
  Rat   397 NEAVYTKMMTKKPGMFFNPEESELDLTYGNRYKNVKLPDAYERLILDVFCGSQMHFVRSDELREA 461

  Fly   467 WRIFTPILHQIEKEHIRPITYQYGSRGPKEADRKCEENNFKYSGSYKW 514
            ||||||:||:|::|..:||.|.||||||.|||...:...|:|.|:|||
  Rat   462 WRIFTPLLHKIDREKPQPIPYVYGSRGPTEADELMKRVGFQYEGTYKW 509

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Zw	NP_523411.1	zwf	35..498	CDD:273312	311/462 (67%)
		G6PD_N	39..213	CDD:278882	106/173 (61%)
		G6PD_C	216..508	CDD:280876	202/291 (69%)
G6pd	NP_058702.1	zwf	30..506	CDD:273312	315/476 (66%)
G6pd	NP_058702.1	Substrate binding. /evidence=ECO:0000250	201..205		3/3 (100%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166335620
Domainoid	1	1.000	419	1.000	Domainoid score	I624
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H37906
Inparanoid	1	1.050	670	1.000	Inparanoid score	I707
OMA	1	1.010	-	-		QHG62474
OrthoDB	1	1.010	-	-		D205418at33208
OrthoFinder	1	1.000	-	-		FOG0001006
OrthoInspector	1	1.000	-	-		oto95843
orthoMCL	1	0.900	-	-		OOG6_100726
Panther	1	1.100	-	-	LDO	PTHR23429
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X665
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	14	13.910