DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Zw and gspd-1

DIOPT Version :9

Sequence 1:	NP_523411.1	Gene:	Zw / 32974	FlyBaseID:	FBgn0004057	Length:	524	Species:	Drosophila melanogaster
Sequence 2:	NP_502129.1	Gene:	gspd-1 / 178046	WormBaseID:	WBGene00007108	Length:	522	Species:	Caenorhabditis elegans

Alignment Length:	523	Identity:	302/523 - (57%)
Similarity:	389/523 - (74%)	Gaps:	15/523 - (2%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MATQKEDHTALDLIIKSLKSPTMVC--EGTHFDGKI--PHTFVIFGASGDLAKKKIYPTLWWLYR 61
            ||.::  |:..|.|.|.|    :.|  |....|.|.  |:.||||||||||||||||||||||:|
Worm     1 MACKR--HSVSDPISKDL----VECLRESMQRDLKFETPYVFVIFGASGDLAKKKIYPTLWWLFR 59

  Fly    62 DDLLPKPTKFCGYARSMLTVDSIKEQCLPYMKVQPHEQKKYEEFWALNEYVSGRYDGRTGFELLN 126
            |:|||...||.|||||.|||..::|......||:.:|:..:::|.....||.|:||...||:.|.
Worm    60 DNLLPVNIKFIGYARSDLTVFKLRESFEKNCKVRENEKCAFDDFIKKCSYVQGQYDTSEGFQRLQ 124

  Fly   127 QQLEIM--ENKNKA-NRIFYLALPPSVFEEVTVNIKQICMS-VCGWNRVIIEKPFGRDDASSQAL 187
            ..::..  |:.|:| ||::|||||||||..|:..:|:.||. ...|.|||||||||.|..||..|
Worm   125 SSIDDFQKESNNQAVNRLYYLALPPSVFNVVSTELKKNCMDHGDSWTRVIIEKPFGHDLKSSCEL 189

  Fly   188 SDHLAGLFQEDQLYRIDHYLGKEMVQNLMTIRFGNKILSSTWNRENIASVLITFKEPFGTQGRGG 252
            |.|||.||:|||:||||||||||||||||.:||||:||:.:|||::||||:|:|||.|||.||.|
Worm   190 STHLAKLFKEDQIYRIDHYLGKEMVQNLMVMRFGNRILAPSWNRDHIASVMISFKEDFGTGGRAG 254

  Fly   253 YFDEFGIIRDVMQNHLLQILSLVAMEKPVSCHPDDIRDEKVKVLKSIEALTLDDMVLGQYLGNPQ 317
            |||..|||||||||||:|||:|||||||.|.:.:|||||||||||:.:.:.|.|:|:|||:.:|:
Worm   255 YFDTAGIIRDVMQNHLMQILTLVAMEKPASLNAEDIRDEKVKVLKAAKVVELKDVVVGQYIASPE 319

  Fly   318 GTNDDARTGYVEDPTVSNDSNTPTYALGVLKINNERWQGVPFILRCGKALNERKAEVRIQYQDVP 382
            ..:.:|..||.:|.:|..||.||||||.|:.||||||:||||.|||||||||:|||||||:::|.
Worm   320 FDHPEASQGYKDDKSVPADSTTPTYALAVVHINNERWEGVPFFLRCGKALNEKKAEVRIQFKEVS 384

  Fly   383 GDIF-EGNTKRNELVIRVQPGEALYFKMMTKSPGITFDIEETELDLTYEHRYKDSYLPDAYERLI 446
            |||: .|..||:|||:||||.||:|.|:|||.||:.|.:|||||||||.:|:|:..||||||||.
Worm   385 GDIYPSGELKRSELVMRVQPNEAVYMKLMTKKPGMGFGVEETELDLTYNNRFKEVRLPDAYERLF 449

  Fly   447 LDVFCGSQMHFVRSDELREAWRIFTPILHQIEKEHIRPITYQYGSRGPKEADRKCEENNFKYSGS 511
            |:||.|||::|||:|||..||||.||:|.:::|:.::|:.|::|||||.|.|...::..|.::|:
Worm   450 LEVFMGSQINFVRTDELEYAWRILTPVLEELKKKKVQPVQYKFGSRGPTEGDELMKKYGFIFTGT 514

  Fly   512 YKW 514
            |||
Worm   515 YKW 517

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Zw	NP_523411.1	zwf	35..498	CDD:273312	285/467 (61%)
		G6PD_N	39..213	CDD:278882	101/177 (57%)
		G6PD_C	216..508	CDD:280876	180/292 (62%)
gspd-1	NP_502129.1	zwf	33..509	CDD:273312	286/475 (60%)
		G6PD_N	37..215	CDD:278882	101/177 (57%)
		G6PD_C	218..509	CDD:280876	179/290 (62%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	381	1.000	Domainoid score	I443
eggNOG	1	0.900	-	-		E1_COG0364
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H37906
Inparanoid	1	1.050	590	1.000	Inparanoid score	I535
Isobase	1	0.950	-	0	Normalized mean entropy	S501
OMA	1	1.010	-	-		QHG62474
OrthoDB	1	1.010	-	-		D205418at33208
OrthoFinder	1	1.000	-	-		FOG0001006
OrthoInspector	1	1.000	-	-		oto19289
orthoMCL	1	0.900	-	-		OOG6_100726
Panther	1	1.100	-	-	LDO	PTHR23429
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R465
SonicParanoid	1	1.000	-	-		X665
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	16	15.860