DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Zw and G6pdx

DIOPT Version :9

Sequence 1:	NP_523411.1	Gene:	Zw / 32974	FlyBaseID:	FBgn0004057	Length:	524	Species:	Drosophila melanogaster
Sequence 2:	NP_032088.1	Gene:	G6pdx / 14381	MGIID:	105979	Length:	515	Species:	Mus musculus

Alignment Length:	503	Identity:	322/503 - (64%)
Similarity:	387/503 - (76%)	Gaps:	9/503 - (1%)

- Green bases have known domain annotations that are detailed below.

  Fly    20 SPTMVC--------EGTHFDGKIPHTFVIFGASGDLAKKKIYPTLWWLYRDDLLPKPTKFCGYAR 76
            |.|.||        :|..|.....|.|:|.||||||||||||||:|||:||.|||:.|...||||
Mouse     8 SRTQVCGILREELYQGDAFHQADTHIFIIMGASGDLAKKKIYPTIWWLFRDGLLPEDTFIVGYAR 72

  Fly    77 SMLTVDSIKEQCLPYMKVQPHEQKKYEEFWALNEYVSGRYDGRTGFELLNQQLEIMENKNKANRI 141
            |.||||.|::|..|:.|..|.|:.|.|||:|.|.||:|:||....::.||..:..:....:|||:
Mouse    73 SRLTVDDIRKQSEPFFKATPEERPKLEEFFARNSYVAGQYDDAASYKHLNSHMNALHQGMQANRL 137

  Fly   142 FYLALPPSVFEEVTVNIKQICMSVCGWNRVIIEKPFGRDDASSQALSDHLAGLFQEDQLYRIDHY 206
            |||||||:|:|.||.||::.|||..||||:|:|||||||..||..||:|::.||:|||:||||||
Mouse   138 FYLALPPTVYEAVTKNIQETCMSQTGWNRIIVEKPFGRDLQSSNQLSNHISSLFREDQIYRIDHY 202

  Fly   207 LGKEMVQNLMTIRFGNKILSSTWNRENIASVLITFKEPFGTQGRGGYFDEFGIIRDVMQNHLLQI 271
            ||||||||||.:||.|:|....|||:|||.|::||||||||:||||||||||||||||||||||:
Mouse   203 LGKEMVQNLMVLRFANRIFGPIWNRDNIACVILTFKEPFGTEGRGGYFDEFGIIRDVMQNHLLQM 267

  Fly   272 LSLVAMEKPVSCHPDDIRDEKVKVLKSIEALTLDDMVLGQYLGNPQGTNDDARTGYVEDPTVSND 336
            |.|||||||.:...||:|||||||||.|..:..|::|||||:|||.| ..:|..||::||||.:.
Mouse   268 LCLVAMEKPATTGSDDVRDEKVKVLKCISEVETDNVVLGQYVGNPNG-EGEAANGYLDDPTVPHG 331

  Fly   337 SNTPTYALGVLKINNERWQGVPFILRCGKALNERKAEVRIQYQDVPGDIFEGNTKRNELVIRVQP 401
            |.|.|:|..||.:.||||.||||||||||||||||||||:|::||.||||....|||||||||||
Mouse   332 STTATFAAAVLYVENERWDGVPFILRCGKALNERKAEVRLQFRDVAGDIFHQQCKRNELVIRVQP 396

  Fly   402 GEALYFKMMTKSPGITFDIEETELDLTYEHRYKDSYLPDAYERLILDVFCGSQMHFVRSDELREA 466
            .||:|.|||||.||:.|:.||:||||||.:|||:..|||||||||||||||||||||||||||||
Mouse   397 NEAVYTKMMTKKPGMFFNPEESELDLTYGNRYKNVKLPDAYERLILDVFCGSQMHFVRSDELREA 461

  Fly   467 WRIFTPILHQIEKEHIRPITYQYGSRGPKEADRKCEENNFKYSGSYKW 514
            ||||||:||:|::|..:||.|.||||||.|||...:...|:|.|:|||
Mouse   462 WRIFTPLLHKIDREKPQPIPYVYGSRGPTEADELMKRVGFQYEGTYKW 509

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Zw	NP_523411.1	zwf	35..498	CDD:273312	308/462 (67%)
		G6PD_N	39..213	CDD:278882	104/173 (60%)
		G6PD_C	216..508	CDD:280876	201/291 (69%)
G6pdx	NP_032088.1	zwf	30..506	CDD:273312	312/476 (66%)
		G6PD_N	35..209	CDD:278882	104/173 (60%)
		Substrate binding. /evidence=ECO:0000250\|UniProtKB:P11413	201..205		3/3 (100%)
		G6PD_C	212..503	CDD:280876	201/291 (69%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167831946
Domainoid	1	1.000	417	1.000	Domainoid score	I652
eggNOG	1	0.900	-	-		E1_COG0364
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H37906
Inparanoid	1	1.050	665	1.000	Inparanoid score	I748
Isobase	1	0.950	-	0	Normalized mean entropy	S501
OMA	1	1.010	-	-		QHG62474
OrthoDB	1	1.010	-	-		D205418at33208
OrthoFinder	1	1.000	-	-		FOG0001006
OrthoInspector	1	1.000	-	-		otm42588
orthoMCL	1	0.900	-	-		OOG6_100726
Panther	1	1.100	-	-	LDO	PTHR23429
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R465
SonicParanoid	1	1.000	-	-		X665
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	17	16.750