DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Zw and H6pd

DIOPT Version :9

Sequence 1:	NP_523411.1	Gene:	Zw / 32974	FlyBaseID:	FBgn0004057	Length:	524	Species:	Drosophila melanogaster
Sequence 2:	XP_006538521.1	Gene:	H6pd / 100198	MGIID:	2140356	Length:	826	Species:	Mus musculus

Alignment Length:	567	Identity:	156/567 - (27%)
Similarity:	261/567 - (46%)	Gaps:	110/567 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly     8 HTAL-DLIIKSLKSPTMVC-EGTHFDGKIPHTFVIFGASGDLAKKKIYPTLWWLYRDD------- 63
            ||.: .:::.::....:.| :.....|.:  :.::.||:||||||.::..|:.||.|:
Mouse    32 HTGIWKMLLAAMCLALLGCLQAQELKGHV--SIILLGATGDLAKKYLWQGLFQLYLDEAGKGHSF 94

  Fly    64 ---------------LLPKPTKFCGYARSML--TVDSIKEQCLPYMKVQPHEQKKYEEFWALNEY 111
                           |:.|..:.....:.::  ..|.:|.|   ::::..:.|.|..|
Mouse    95 SFHGAALTAPQQGQKLMDKVLESLSCPKDLVPSRCDELKGQ---FLQLSQYRQLKTVE------- 149

  Fly   112 VSGRYDGRTGFELLNQQLEIMENKN---KANRIFYLALPPSVFEEVTVNIKQICMSVCG-WNRVI 172
                     .::.||:.:|....::   :|.||||.::||..:.::..||...|....| |.||:
Mouse   150 ---------DYQTLNKDIETQVQQDGLWEAGRIFYFSVPPFAYADIARNINSSCRPHPGAWLRVV 205

  Fly   173 IEKPFGRDDASSQALSDHLAGLFQEDQLYRIDHYLGKEMVQNLMTIRFGN-KILSSTWNRENIAS 236
            .|||||.|..|:|.|:..|...|||:::||:||||||:.|..::..|..| |.|...|||.::..
Mouse   206 FEKPFGHDHLSAQQLASELGSFFQEEEMYRVDHYLGKQAVAQILPFRDQNRKALDGLWNRHHVER 270

  Fly   237 VLITFKEPFGTQGRGGYFDEFGIIRDVMQNHLLQILSLVAMEKPVSCHPD-DIRDEKVKVLKSIE 300
            |.|..||....:||..:::|:|:|||.:||||.:||:|||||.|::.... .:...|:...:::.
Mouse   271 VEIILKETIDAEGRASFYEEYGVIRDTLQNHLTEILTLVAMELPLNISSSAAVLQHKLWAFQALR 335

  Fly   301 ALTLDDMVLGQYLGNPQGTNDDARTGYVEDPTVSND---SNTPTYALGVLKINNERWQGVPFILR 362
            .|.....:||||         .|.:|.|.......|   |.|||:|..::.|:|.||:||||||.
Mouse   336 GLQKSSAILGQY---------QAYSGQVRRELQKPDGFQSLTPTFAGVLVHIDNLRWEGVPFILM 391

  Fly   363 CGKALNERKAEVRIQYQD-----------VPGDIFEGNTKRNELVIRVQPGEALY---------- 406
            .||||:||...|||.:::           ||.   :......:::..:..||..:
Mouse   392 SGKALDERVGYVRIVFKNRAYCTQSERHWVPE---QSRCLPQQIIFYIGHGELGHPAILVSRNLF 453

  Fly   407 --------FKMMTKSPGITFDIEETELDLTYEHRYKDSYLPDAYERLILDVFCGSQMHFVRSDEL 463
                    :|.:...||:..    ....|:..:.|:.....|||..|:..:|...:..|:.::.|
Mouse   454 KPSLPTQKWKEVQDQPGLRL----FGRPLSDYYAYRPVREQDAYSTLLSHIFHCRKESFITTENL 514

  Fly   464 REAWRIFTPILHQIEKEHIRPITYQYGSRGPKEADRKCEENNFKYSG 510
            ..:|..:||:|..:..|..||  |..|:...:..|       |::||
Mouse   515 LASWVFWTPLLDSLAFEVPRP--YPGGAENGQLLD-------FEFSG 552

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Zw	NP_523411.1	zwf	35..498	CDD:273312	148/524 (28%)
		G6PD_N	39..213	CDD:278882	58/201 (29%)
		G6PD_C	216..508	CDD:280876	91/325 (28%)
H6pd	XP_006538521.1	PTZ00309	60..539	CDD:240353	147/517 (28%)
H6pd	XP_006538521.1	pgl	591..826	CDD:273494
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0364
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D205418at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.820