DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Zw and h6pd

DIOPT Version :9

Sequence 1:	NP_523411.1	Gene:	Zw / 32974	FlyBaseID:	FBgn0004057	Length:	524	Species:	Drosophila melanogaster
Sequence 2:	XP_031760646.1	Gene:	h6pd / 100127695	XenbaseID:	XB-GENE-988586	Length:	801	Species:	Xenopus tropicalis

Alignment Length:	556	Identity:	168/556 - (30%)
Similarity:	282/556 - (50%)	Gaps:	89/556 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly    12 DLIIKSLKSPTMVCEGTHFDGKIPH----TFVIFGASGDLAKKKIYPTLWWLYRDD--------- 63
            ::::|:|.  .|:...|:|.....|    :.::.||:||||||.::..|:.||.::
Frog    12 NMLLKALL--IMLLLETNFVDCKEHKGHISVILVGATGDLAKKYLWQGLFHLYLNEADRGHSFIF 74

  Fly    64 ---LLPKPTKFCGYARSML---------TVDSIKEQCL----PYMKVQPHEQKKY-EEFWALNEY 111
               .|..|.|    ..|::         .||...::|.    .::::..:.|.|. |.:.|||:
Frog    75 YGGALSPPEK----GESIMFDVLKSLSCPVDVTPDRCALLKDQFLRLSRYRQLKVAENYTALNQ- 134

  Fly   112 VSGRYDGRTGFELLNQQLEIMENKNKANRIFYLALPPSVFEEVTVNIKQICMSVCG-WNRVIIEK 175
                       ::.|...|  |..::|.|:|||::||..:.::..||...|..:.| |.||::||
Frog   135 -----------DIQNTMSE--EGLHEAGRLFYLSVPPFTYTDIARNINATCRPLPGAWLRVVLEK 186

  Fly   176 PFGRDDASSQALSDHLAGLFQEDQLYRIDHYLGKEMVQNLMTIRFGN-KILSSTWNRENIASVLI 239
            |||.|.||:|.|:..|...|:|:::|||||||||:.|..::..|..| :.|...|||:.:..|.|
Frog   187 PFGHDYASAQQLASDLQMFFKEEEIYRIDHYLGKQTVAQILPFRRQNRRHLDPIWNRDYVERVEI 251

  Fly   240 TFKEPFGTQGRGGYFDEFGIIRDVMQNHLLQILSLVAMEKPVSCHPD-DIRDEKVKVLKSIEALT 303
            ..||....:.|..:::|:|:||||:||||.:||:.::||.|::.... |:...|::|:.|:.:|.
Frog   252 VLKETVDAKARTSFYEEYGVIRDVIQNHLTEILTSLSMELPLNYSKSYDVLKAKLEVMNSLLSLD 316

  Fly   304 LDDMVLGQYLGNPQGTNDDARTGYVEDPTVSND--SNTPTYALGVLKINNERWQGVPFILRCGKA 366
            ....|:|||        .:..|...|:....:|  :||.|:|..:::|:|.||:||||||..|||
Frog   317 HRSAVVGQY--------QNYLTQVREELEKKSDFFTNTQTFAGVLVQIDNTRWEGVPFILTSGKA 373

  Fly   367 LNERKAEVRIQYQD--------VPGDIFEGNTKRNELVIRVQPGEALYFKMMTKSPGI---TFDI 420
            |:||.|.||:.::|        |..:..:.:.||.:::..:..|: |.|..:..|.|:   .|..
Frog   374 LDERTAYVRVLFKDNSFCLQKEVNRETGKTSCKRKQIIFHIGHGD-LGFPAILVSRGLFKPKFSS 437

  Fly   421 ----EETEL--------DLTYEHRYKDSYLPDAYERLILDVFCGSQMHFVRSDELREAWRIFTPI 473
                |.|||        .||..:.|:.....|||..||.::|.|.:..||.:..|..:|:.:||:
Frog   438 SQWQEATELTSLHLFGQPLTDYYVYRPVQEMDAYSLLISNIFYGKKETFVTTKNLLSSWKFWTPL 502

  Fly   474 LHQIEKEHIRPITYQYGSRGPKEADRKCEENNFKYS 509
            |..:::|  .|..|..|:...:..|...|....:::
Frog   503 LEILDRE--SPRVYLGGTENDQLLDFVIESGGLQFA 536

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Zw	NP_523411.1	zwf	35..498	CDD:273312	161/520 (31%)
		G6PD_N	39..213	CDD:278882	63/200 (32%)
		G6PD_C	216..508	CDD:280876	98/318 (31%)
h6pd	XP_031760646.1	PTZ00309	38..518	CDD:240353	159/508 (31%)
h6pd	XP_031760646.1	Glucosamine_iso	570..792	CDD:395940
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D205418at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.920