DRSC/TRiP Functional Genomics Resources

powered by:
logo

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Elys and Ahctf1

DIOPT Version :9

Sequence 1:NP_001285454.1 Gene:Elys / 32971 FlyBaseID:FBgn0031052 Length:2111 Species:Drosophila melanogaster
Sequence 2:NP_080651.2 Gene:Ahctf1 / 226747 MGIID:1915033 Length:2243 Species:Mus musculus


Alignment Length:2449 Identity:511/2449 - (20%)
Similarity:860/2449 - (35%) Gaps:633/2449 - (25%)


- Green bases have known domain annotations that are detailed below.


  Fly    11 SRTIAFPERIVPGFGREPSAHLDAAEYLGGIIRDGQWGWVTWRYGSDATLLVCSMSTGDYLSWHC 75
            |..:.|||..:...|.:   .:.....|.|....|:.|......|..  |.|.:..||:.||.: 
Mouse    10 SDLLHFPEVTIEALGED---EITLESVLRGKFAAGKNGLACLACGPQ--LEVVNSLTGERLSAY- 68

  Fly    76 FWSESDDLGPRKSIRCVEELFPGEHER-PAMLAICLESWN--SGDQRPIDCPLSTQVLIYAIRNS 137
                               .|.|.:|: |.:||:...||:  :|....::....:.:.:|.:..|
Mouse    69 -------------------RFSGVNEQPPVVLAVKEFSWHKRTGLLIGLEEADGSVLCLYDLGIS 114

  Fly   138 QVLRRFDL------------HGITCSALTFLDKRIYGLTRLRRFKGCLAVATEEGTVLLVDLNSD 190
            :|::...|            ||...::...|.      ..||...|..||.|:.|.:||:||..|
Mouse   115 RVVKAVVLPGRVTAIEPIINHGGASASTQHLH------PSLRWLFGVAAVVTDVGQILLIDLCLD 173

  Fly   191 SLQASTQRRSLCSPSSKDEPSDGNLYFVSSEESKRQLSSKLTHCRSK----GAHLAVRMDVASIG 251
            .|..           |::|....:|..::.      :.:::.|.|.:    |.||..:: |:.:|
Mouse   174 DLSC-----------SQNEVEASDLEVITG------IPAEVPHIRERVMREGRHLCFQL-VSPLG 220

  Fly   252 --ISCLMGISMAPGYAAGLEDGRILIYDL--INFDVTTDLNSPVKRKGVNRAVKRMCLIMPPDDP 312
              ||.|..|:.....|.|..||.:.::::  :..:..|.|      :|....|..:....|.:||
Mouse   221 VAISTLSYINRTNQLAVGFSDGYLALWNMKSMKREYYTQL------EGGRVPVHAVAFQEPENDP 279

  Fly   313 KPCFYICALYQNI----DVLQMML-------------HSVCYRGSYRDRETHTIRFK----DYRS 356
            :.|.|:.|:....    |||.:.|             ..:.|.|.....|.:|:...    ..|.
Mouse   280 RNCCYLWAVQSTQDSEGDVLSLHLLQLAFGDRKCLASGQILYEGLEYCEERYTLDLAGGTFPLRG 344

  Fly   357 RTVRNRQILDGGICSVIGCATASTFSFAGDN----------GTLLIVISWHSSADKKNK----LV 407
            :|...:         ::||.:...|...||.          .|.:.|.:|..:...:.|    |.
Mouse   345 QTSNTK---------LLGCQSIERFPSHGDREESMREALSPDTSVSVFTWQVNIYGQGKPSVYLG 400

  Fly   408 LFDINQWYKDEMPTSVHKNEVPNYMSGYILSGLQTGLA-------LDLRSTTILHFVSLQR---- 461
            |||||:||..:||.|:...|..:..|.:.|..|.:.::       ||:    ::|..||.|    
Mouse   401 LFDINRWYHAQMPDSLRSGESLHNCSYFALWSLDSVVSRTSPHHILDI----LVHERSLNRGVPP 461

  Fly   462 -Y---DEHFYPNSLTFDCSLLTPTGKRYYAQDGVQHRFLNALRCDRATL-FLRPQIYHEDIVRLR 521
             |   ::.|.|::..||.:.|..:|..:....|.|...|..|:....|| .:.|..|:..:|...
Mouse   462 SYPPPEQFFNPSTFNFDATCLLDSGVIHVTCAGFQKETLTFLKKSGPTLNEVIPDSYNRCLVAGL 526

  Fly   522 LLPQFCELNPNATFSKIAMYELILSVALEHNCGALLNDCARSWMDGSFLCNMIDNTQLSLSTLTN 586
            |.|:..::.| ::.|:....|.|||.|::.:...||....|:|     :.....|:..:|..:..
Mouse   527 LSPRLIDIQP-SSLSQEEQLEAILSAAIQTSSLGLLTGYIRTW-----IIEEQPNSAANLRFVLE 585

  Fly   587 WILKRAGQIKTRCSELCHGIFDYGGYPLDQRERREFQ---VLSGQLRELVRLQSYIVE-QGRRRL 647
            |...:....|.....||..:||.....:|.:..:..|   :|...|..:  |..:.:| ||   :
Mouse   586 WTWNKVVLTKEEFDRLCVPLFDGSCRFIDPQTIQSIQQCHLLLSNLSTV--LSCFAMEAQG---I 645

  Fly   648 TSSILDDCRANERALKTVLEYQRVLLWFIDHGLLPEGQHMDNLV---------PGEQAFVRLQHE 703
            |...|.|........:.:.:|..::|||...||||||  :|:.:         |..|.:...:.:
Mouse   646 TERGLVDLSNKHMVTQLLCQYAHMVLWFCHSGLLPEG--LDDALQLSRLRYNYPVIQNYYTSRRQ 708

  Fly   704 YSEKRAQGK----ILYIDSL-------------------GKRASFPEPYPPDSLHAYIHLMLSPD 745
            .||:..:||    .|.||.|                   |:       |||.|:||.:.:.|..:
Mouse   709 KSERSPRGKWNHDCLMIDGLVSQLGDEVEKLWKRDEGGTGR-------YPPASIHALLDIYLLDN 766

  Fly   746 IELCHKHALILYLLMDLNQQL-------VGRFQIAFQLDKDLATSLRCFWYLDHGDYERGVEELY 803
            |....|||:.:|||:|:....       :..|..||.:.......::.||.|||.|||.|::.|:
Mouse   767 ITEASKHAITIYLLLDIMYSFPNKTDTPIESFPTAFAISWGQVKLVQGFWLLDHNDYENGLDLLF 831

  Fly   804 KEPAPAKNLKSWQMRLLIDKLLAEGAVKAAKKVVSRPPGPLSSA----LHMKVLLANENITEAFQ 864
             .|..||. .|||...:|:..:::|..|.|.:.:......:||:    ||:.|||.|..:.||:.
Mouse   832 -HPVTAKP-ASWQHSKIIEAFMSQGEHKQALRYLQTMKPTVSSSNEVILHLTVLLFNRCMVEAWN 894

  Fly   865 IARLDDDE-DGQPLLERFFRHCIEIRRFKVLAELYLREPEERLLYSLLRQCRSRQTDCVQLIMLL 928
            :.|.:.:. :.:.||:..:..|.|:...:.|.:|.....|:..|...|:...|.:.....|:..|
Mouse   895 LLRQNSNRVNIEELLKHAYEVCQEMGLMEDLLKLPFTNTEQECLVKFLQSSTSVENHEFLLVHHL 959

  Fly   929 QKSKFIEAVS---------FMDEVAAERERDESSNTILPAYSATMGPVTQNIA-----GTYLRIR 979
            |::.:|.|:.         ..|.....|||..:.|:||..|...:..|.:.:|     ..:|...
Mouse   960 QRANYISALKLNQILKNNLMSDRDPRLRERSVTRNSILDQYGKILPRVQRKLAVERAKPYHLSTS 1024

  Fly   980 DTLEPYQKTGPLEPFSCQLVK----------QNASGQLGGIFQS----SAVSAHWATQCESPPKM 1030
            .......:..||..|..:.:.          .|...::|.::.|    :.||...:.:.|.|   
Mouse  1025 SVFHEVSRPKPLSAFPKKAITGTVLTRSTFISNVLSKIGEVWASHEPRNGVSLFNSPKTEQP--- 1086

  Fly  1031 TPVSIQSKIGYTNVPFLRHAQYGHSELP-----------------LPRRIVKPVPH--QVVEKRQ 1076
            :||.              |: :.|.|||                 |...:|.|||.  |.:|..|
Mouse  1087 SPVV--------------HS-FPHPELPEAFVGTPISNTSQRISRLLDLVVHPVPQPSQCLEFIQ 1136

  Fly  1077 RELEDQRTNLQDQRQLGTERPNKRP-CLMVERMVEDVKDYVRSIREKSSNQMEQEEVKQNEATN- 1139
                              :.|.:.| ||:                 .||..:..:..:.::.|: 
Mouse  1137 ------------------QSPTRSPLCLL-----------------SSSLPLSSQFKRPHQNTSR 1166

  Fly  1140 -----LLQPPNFLQARQSTTIRQSSSS-PQPIPPILKGSGAVDAVKRAPPVATFTALAGPKRFR- 1197
                 ||:.|..::..:|..:..:||. .:..||.:..||.......:|.::...:|..|.|.: 
Mouse  1167 PSELLLLETPLIVKKAKSLALSATSSGFAEFTPPSILRSGFRTTPLASPSLSPGRSLTPPFRVKE 1231

  Fly  1198 --------------------------FVPP------IPLRTD---KSDKSTEMGSEGAAEGEEE- 1226
                                      ||..      :|..|:   .|||:|....:..|:|.:: 
Mouse  1232 TRISFMEEGMNTHWTDRATDDRNTKAFVSTSFHKCGLPAETEWMKTSDKNTYFPLDVPAKGPQKV 1296

  Fly  1227 TDEIIVEIESR------SEPRSACSYESD----EEDEFLSPLVSANVSLVDPVPSRNSPHY---- 1277
            ..|.:.....|      |:..|..|..||    |..:..||........|.|.|:.:|...    
Mouse  1297 VAESLATHSGRLEKLDVSKEDSTASTRSDQTSLEYHDAPSPEDLEGAVFVSPKPASSSTELTTNS 1361

  Fly  1278 ------------FAPPAGPQPRNSLLHGGNGSGSKIGTATGSESSSGFGSFSTVQPAQTSSHSQF 1330
                        |.....|.|..          .:||  ||..:...|...|.:.|.:.:..|..
Mouse  1362 TLQTERDNDKDAFKSEGAPSPVK----------KQIG--TGDAAVEAFSELSRLDPVERAEASFA 1414

  Fly  1331 VPTVCSSK-------------------------------MGETQSQVFSSGSCGIKISERTTICG 1364
            |.:||..:                               :..|.:.|.||||...|       |.
Mouse  1415 VSSVCEGETSTSNSKTSVLDGIVPIESRTSILTADHKESVANTVADVESSGSTSSK-------CP 1472

  Fly  1365 EMESTDLGAELTA----------APSAQWSLPSARPAIQG----HHQMMDTTLGMSTYDVASLEQ 1415
            ......||.:||.          .|.....||...|.|..    .|::  ..:|....:|.:.| 
Mouse  1473 VTSERSLGQKLTLNLKEDEIEAHVPKENVGLPEESPRISAAPSDTHEI--HLIGCENLEVQNSE- 1534

  Fly  1416 QDTQDVENEEELKLGDTK------SLEEQQNPQDEQKPEQEQDQDEDQAQEPLATGGQLAFLSNS 1474
            ::.:::..:|...||..|      ::|:|.....:.|...|.|..|...:..:|.......|...
Mouse  1535 EEAKNLSFDELYPLGAEKLEYNLSTIEQQFCDLPDDKDSAECDAAEVDGELFVAQSNFTLILEGE 1599

  Fly  1475 EGTAQEPLSSPIYSLSSEDSNVSSAGIRNPMLPTLHTDDPMYSIVVESPGSITTSRSVTHTPTSF 1539
            ||.|:           :.||...:      |||....:.|   :....|.:   ...||..|::.
Mouse  1600 EGEAE-----------ASDSAAPN------MLPKATKEKP---VCHREPHN---QERVTDLPSAV 1641

  Fly  1540 LPSDTNVSQTSSPQAPHGEDGDGTPISLYRANSLETVDDLDTTKGSLEEE-------EEYDDDDC 1597
            .....:....:.|..|.       |:.:..|.:|     ||..|.:..:|       |..|:|..
Mouse  1642 TADQESHKVETLPYVPE-------PVKVAIAENL-----LDVIKDTRSKEATPVAAGEAGDEDGA 1694

  Fly  1598 VIALDGTEVRGYVARPQQSAASSSAELFAFKDECQEEAAGVPSPFLSL---GATVNSDSDVADTI 1659
            ||    .....:.:|...|...:..|..|......:....|.|..|:.   ..::|..|:...:.
Mouse  1695 VI----VSKAAHSSRLTNSTPKTVKEPHAETVNTSQNDDMVSSRTLTRRQHALSLNVTSEQEPSA 1755

  Fly  1660 VLDSDEETAKEKDTQPEQRKDWPMEEETPSNESVATVEFSEQKQPRADMDIGMEVDAVPDVLEVL 1724
            |....:.|.|.|:|.....:.....:..|.|:..|....:.::..:.|:..|    .:|....|.
Mouse  1756 VATPKKRTRKIKETPESSERTCSDLKVAPENQLTAQSPPAPRRGKKKDVSQG----TLPSSGAVE 1816

  Fly  1725 EVPEMEPLP---VLSDVDIEMAVDEVPNVLEV--LEVPELEPLPAGQATQSSGLGEIPEEDVDAE 1784
            ..||.:..|   .|.....|.|.:|.|:..:|  ..|.:..|....::.::....||.::...:|
Mouse  1817 PEPEPQGTPGRLRLRTQPPEPAAEETPSRTKVRLSSVRKGTPRRLKKSVENGQSTEILDDLKGSE 1881

  Fly  1785 AEEQVVVKVEHVADEQPKEGDKTESKEASEEETQHNPEPLLPEEEDSRHSLKLIFSGDEDEEEQD 1849
            |...              :|..||.:.|:.|:||:.                        |.:||
Mouse  1882 AASH--------------DGTVTELRNANLEDTQNM------------------------EYKQD 1908

  Fly  1850 VPTRAIHTLRPRRSFTEHQDSPRTLRPRRVSQEHRDSPTPVAGRTMSLRS-TDAPTLSPASNP-- 1911
                            ||.|....|:.:||.:           |.:|:.| |:.|.|..:..|  
Mouse  1909 ----------------EHSDQQLPLKRKRVRE-----------REVSVSSVTEEPKLDSSQLPLQ 1946

  Fly  1912 -----PVSTPKRRGLQHKYL-LEV------IDEHSPSDLSLPRTRSRTRLSVDSEATSSRPGTPT 1964
                 | :||::||...|.: ||.      .::.||....:|..|..||.:.....::.......
Mouse  1947 TGLDVP-ATPRKRGRPRKVVPLEADGGTTGKEQTSPQKKDVPVVRRSTRNTPARNVSTLEKSVLV 2010

  Fly  1965 MTKARGKRATSQAPPTASPSVRRSLRGHSEPPAALSAQLVRKPKTARAGVRSRKTSSGVQSPVAV 2029
            ..|......||:..||     ::|....|:.|:|..:.|.    ...|...|.....|:.:..|:
Mouse  2011 PNKEAALVVTSKRRPT-----KKSAEESSKDPSAAVSDLA----GGAAHTESADRRDGLLAAAAL 2066

  Fly  2030 SP---------------TPIDAPIDVPDSTAPEEEQPRLRRTA---------RRRISELSDQSAN 2070
            :|               |.|..|...|....|..:.|:.:..|         :..:|:||.|...
Mouse  2067 TPSAQGTRTRSRRTMLLTDISEPKTEPLFPPPSVKVPKKKSKAENMEAAAQLKELVSDLSSQFVV 2131

  Fly  2071 GTGDLRSEASSSRTGSKSNSAASTQNR-----ELRPRLRRTSKS 2109
            ....||:...|....||......:..:     |.:|:..||.|:
Mouse  2132 SPPALRTRQKSISNTSKLLGELESDPKPLEIIEQKPKRSRTVKT 2175

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
ElysNP_001285454.1 ELYS-bb <166..482 CDD:293292 87/373 (23%)
ELYS 713..917 CDD:290645 63/234 (27%)
Ahctf1NP_080651.2 Necessary for cytoplasmic localization. /evidence=ECO:0000269|PubMed:11952839 1..981 247/1060 (23%)
Seven-bladed beta propeller repeats. /evidence=ECO:0000269|PubMed:23499022 1..494 120/551 (22%)
ELYS-bb 2..489 CDD:293292 120/546 (22%)
Important for nuclear localization. /evidence=ECO:0000250|UniProtKB:Q8WYP5 591..1092 125/533 (23%)
ELYS 722..947 CDD:290645 63/233 (27%)
Disordered. /evidence=ECO:0000303|PubMed:23499022 1019..2243 254/1350 (19%)
Necessary for nuclear localization. /evidence=ECO:0000269|PubMed:11952839 1149..2243 224/1167 (19%)
Mediates transcriptional activity. /evidence=ECO:0000269|PubMed:11952839 1447..1694 58/291 (20%)
Important for nuclear localization and chromatin binding. /evidence=ECO:0000250|UniProtKB:Q8WYP5 1828..2243 85/423 (20%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C167842108
Domainoid 1 1.000 84 1.000 Domainoid score I8298
eggNOG 1 0.900 - - E1_28MGV
Hieranoid 1 1.000 - -
Homologene 00.000 Not matched by this tool.
Inparanoid 1 1.050 215 1.000 Inparanoid score I3611
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 1 1.000 - - FOG0008333
OrthoInspector 1 1.000 - - oto94620
orthoMCL 1 0.900 - - OOG6_109686
Panther 1 1.100 - - LDO PTHR21583
Phylome 1 0.910 - -
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R4555
SonicParanoid 1 1.000 - - X6313
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 1 0.960 - -
1312.780

Return to query results.
Submit another query.