Protein Alignment Ranbp21 and CRM1

DIOPT Version :10

• Sequence 1: NP_608339.2
• Gene: Ranbp21 / 32970
• FlyBaseID: FBgn0031051
• Length: 1241
• Species: Drosophila melanogaster
• Sequence 2: NP_011734.3
• Gene: CRM1 / 853133
• SGDID: S000003450
• Length: 1084
• Species: Saccharomyces cerevisiae
• Alignment Length: 1076
• Identity: 203/1076 - (18%)
• Similarity: 397/1076 - (36%)
• Gaps: 300/1076 - (27%)

  Fly    18 IDLVMNPMTQ----QQARLEAYMACERFKEESPMCAQVGLFLASSPQSNQQVRHFGLQLIEYTIK 78
            :|.|::...|    ||.:.:..:.  :|::......:....|..|  :|.|.:...|.:::..|.
Yeast    16 LDQVVSTFYQGSGVQQKQAQEILT--KFQDNPDAWQKADQILQFS--TNPQSKFIALSILDKLIT 76

  Fly    79 YRWNCITHEEKVYIKDNAIKMLNVGVGPAEDRSLLPT-KDALSR---IIVEMIKREWPQQWSDLL 139
            .:|..:.::.::.|::..:.|:   :...:|..:..| |:.:::   .:|:::|:||||.|.:.:
Yeast    77 RKWKLLPNDHRIGIRNFVVGMI---ISMCQDDEVFKTQKNLINKSDLTLVQILKQEWPQNWPEFI 138

  Fly   140 PEL--SQACTKGEAQTELVLLVFLRLVEDVALLQTIESNQRRKDMYQALNNNMNDIFEFFLRLVE 202
            |||  |.:.:....:..:::   |:|:.:.....:.|...:.|.::  |.|:|:..||...:|..
Yeast   139 PELIGSSSSSVNVCENNMIV---LKLLSEEVFDFSAEQMTQAKALH--LKNSMSKEFEQIFKLCF 198

  Fly   203 QHVTAFRETTRLCNYTKANAHSRVVEMVLLTLSGFVEWVSIQHIMSSNGKLMHFLCILLNDKAF- 266
            |             ..:..:.|.::...|.:|..::.|:..::|..:|      :..||:.|..
Yeast   199 Q-------------VLEQGSSSSLIVATLESLLRYLHWIPYRYIYETN------ILELLSTKFMT 244

  Fly   267 ----QCNAAECLAQITNRKGQTKERKPLLQ----LFNEEPLRYIYQASQIP--ADTSSTLAVE-- 319
                :....:||.:::|.|  ..:...|::    ||.:..|:.| ..|.:|  ||..:|.|..
Yeast   245 SPDTRAITLKCLTEVSNLK--IPQDNDLIKRQTVLFFQNTLQQI-ATSVMPVTADLKATYANANG 306

  Fly   320 QHLNFLKKLLQVLNGMAQQLVALWGKDDATQRPVHLEVLLECLLLLVQHPSLGLSHGSALIWQLL 384
            ...:||:.|...|.....:..||...|::.:     |:||.....|:|                |
Yeast   307 NDQSFLQDLAMFLTTYLARNRALLESDESLR-----ELLLNAHQYLIQ----------------L 350

  Fly   385 LKHEPSSKDFAMVNYIPKLIHTIAPRIVKLPYPASASSP---ASLSTEAYIRLEHDSEEEYALYF 446
            .|.|........::|...|:..:...:.:|  ||:..||   .|:.::|..........||...|
Yeast   351 SKIEERELFKTTLDYWHNLVADLFYEVQRL--PATEMSPLIQLSVGSQAISTGSGALNPEYMKRF 413

  Fly   447 FRCRTDFLEIFRLATLVQPLVTYGYCEQWLQQRLRNAQIEADAEVKSGNVSCSVLDPVYLEWDAL 511
                              ||..:.|.|                       .||.|        .|
Yeast   414 ------------------PLKKHIYEE-----------------------ICSQL--------RL 429

  Fly   512 VSVLDGVLSRILLVAERPSVPAGLRLLEECLKLETI-------NPLTYSILLSCISALFVFLSMS 569
            |.:.:.|....:||.|...   |..:.|...:.:||       ..|.|...|:.|....:.:|..
Yeast   430 VIIENMVRPEEVLVVENDE---GEIVREFVKESDTIQLYKSEREVLVYLTHLNVIDTEEIMISKL 491

  Fly   570 ACQITA---------TNCVAMSGVS-LLPRVLDKIFRALVMKPPNELEKVQAKSAKNLRRHAASL 624
            |.||..         |...|:..:| .:....:|.|...|:|  :.|:....|..|:.:...||.
Yeast   492 ARQIDGSEWSWHNINTLSWAIGSISGTMSEDTEKRFVVTVIK--DLLDLTVKKRGKDNKAVVASD 554

  Fly   625 LVKLAHKYP-----------LLLLPVFEQINGHVE--------------------LLLKEPGKHQ 658
            ::.:..:||           .::|.:||.::...|                    .::::|.:.:
Yeast   555 IMYVVGQYPRFLKAHWNFLRTVILKLFEFMHETHEGVQDMACDTFIKIVQKCKYHFVIQQPRESE 619

  Fly   659 LCRLMRTTLQEALILISNHFCDFERQTLFIEH-----IVQDKRTEWLAFGDALKSPLDFMSFVGL 718
              ..::|.:::    |.....|.:.|.:...:     |:.::|:  :|..:.|.|  |.|..
Yeast   620 --PFIQTIIRD----IQKTTADLQPQQVHTFYKACGIIISEERS--VAERNRLLS--DLMQL--- 671

  Fly   719 DKPPIFAVEGAV--TLQNRSRLLDA--LHVVLGVVKRCTWPDDPERAQRGGFVIGCTELGNPICR 779
               |..|.:..|  :..|.:.|||:  :.::..::|.              .|..||.:|
Yeast   672 ---PNMAWDTIVEQSTANPTLLLDSETVKIIANIIKT--------------NVAVCTSMG----- 714

  Fly   780 NPATKHIVPLLSHV----LSLMRVLNELFAPEALQALSEG--------YRGIHGMMEHEKKLLMG 832
                ....|.|.|:    |.|.|.::.:.   :.|..:||        .||:..:.:...||:..
Yeast   715 ----ADFYPQLGHIYYNMLQLYRAVSSMI---SAQVAAEGLIATKTPKVRGLRTIKKEILKLVET 772

  Fly   833 ICALPTDPLDTTIR--SEPTAFEKMQTFMMMVTEG----CYHLMGSAGPSLGRDLYQLMGLSDAI 891
            ..:...: ||..::  .||.....::.:|..|.:.    ..:.|.:....:|..:.|.:.|   |
Yeast   773 YISKARN-LDDVVKVLVEPLLNAVLEDYMNNVPDARDAEVLNCMTTVVEKVGHMIPQGVIL---I 833

  Fly   892 VTNVFS-RMDLV-------PDYR------LRPIIRVFFKPFVYSCPPS----FYDSVLVPLFAHL 938
            :.:||. .:|::       |::|      |:.|....|..|: ..||:    |.|::
Yeast   834 LQSVFECTLDMINKDFTEYPEHRVEFYKLLKVINEKSFAAFL-ELPPAAFKLFVDAI-------- 889

  Fly   939 APLMCERLTRRWIYIASLYESGQLDGEVNDTQEVLE 974
                |      |     .::....|.|||..|..|:
Yeast   890 ----C------W-----AFKHNNRDVEVNGLQIALD 910

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ranbp21	NP_608339.2	IBN_N	34..101	CDD:397745	10/66 (15%)
		Xpo1	116..274	CDD:462459	32/167 (19%)
		Exportin-5	319..1196	CDD:437105	139/754 (18%)
CRM1	NP_011734.3	CRM1	1..1070	CDD:227432	203/1076 (19%)