Protein Alignment Ranbp21 and MSN5

DIOPT Version :10

• Sequence 1: NP_608339.2
• Gene: Ranbp21 / 32970
• FlyBaseID: FBgn0031051
• Length: 1241
• Species: Drosophila melanogaster
• Sequence 2: NP_010622.1
• Gene: MSN5 / 851935
• SGDID: S000002743
• Length: 1224
• Species: Saccharomyces cerevisiae
• Alignment Length: 1437
• Identity: 275/1437 - (19%)
• Similarity: 487/1437 - (33%)
• Gaps: 437/1437 - (30%)

  Fly    11 AAELASAIDLVMNPMTQQQARLEAYMACERFKEESPMCAQV---GLFLASSPQSNQQVRHFGLQL 72
            |:::.||:|::.:|.:....|.||    ::|.:|..:|::.   |..:|....:|..:::|||.|
Yeast     6 ASQIVSALDVIYSPKSNNSQRQEA----QKFLDEVKLCSESPFWGYEIALQNPTNSILKYFGLGL 66

  Fly    73 IEYTIKYRWNCITHEEKVYIKDNAIKMLNVGVGPAEDRSLLPTKDALSRIIVEMIKREWPQ---- 133
            :::.:|..||.....::|.:: ..:..||.||...:.|.:   |:.|:.:.||:.||.|.:
Yeast    67 LDHAVKKNWNDYDEGKRVALR-KWVMELNFGVQDYDTRYI---KEKLATLWVEVAKRTWGEALKQ 127

  Fly   134 ----------QWSDLLPELSQACTKGEAQTELVLLVFLRLVEDVALLQTIESNQRR--------- 179
                      .|.|:...|.:.....::..||.|::|..|.|||.||..:...:|.
Yeast   128 TNPTEEQLLTSWVDMDNNLFELWNINQSSRELALIIFRILFEDVFLLDDLIVLKRMTVIQPLCVM 192

  Fly   180 --------------KDMYQALNNNMNDIFEFFLRLVEQHVTAFRETTRLCNYTKANAHSRVVEMV 230
                          .|.:.....|....|..::             ..|.|..:.| :|..:..:
Yeast   193 IVCPIEVFAIKYKFSDKWTKFKANEEGWFSVWI-------------PELNNALQQN-NSEYIIRL 243

  Fly   231 LLTLSGFVEWVSIQHIMSSNGKLMHFL-CILLNDKAFQCNAAECLAQITNR--KGQTKERKPLLQ 292
            |.||...:.| .:..::..|..|...| |:..|....|..|.:.:..:..|  ..::..:..:.:
Yeast   244 LETLKTCLNW-PLTEVIVRNDVLSSLLTCLSSNIPRAQSMALDSIHILLTRPYSNESHYQMTIDR 307

  Fly   293 LF-NEEPLRYIYQASQI-PADTSSTLAVEQHLNFLKKLLQVL-------------NGMAQQLVAL 342
            :| |.:.|..:|::... |.|...    |.....:||.:.::             ||..|:...|
Yeast   308 VFDNMDLLDSVYESLLFDPTDDID----ETKYPIIKKFVDMISCLYVCVPKIKETNGQIQKYFKL 368

  Fly   343 WGKDDATQRPVHLEVLLECLLLLVQHPSLGLSHGSALIWQLLLKHEPSSKDFAMVNYIPKLIHTI 407
                               :|....:|||.:|..:..:|...|:::         .|:|||...:
Yeast   369 -------------------VLKTTYNPSLIVSGLTLDLWCTCLRND---------EYLPKLEKYV 405

  Fly   408 APRIVK-----LPYPASASSPASLSTEAYIRLEHDSEEEYALYFFRCRTDFLEIFRLATLVQPLV 467
            .|.:::     |.|........|   :.:..::..|:.|:..:....|....:|.||.:.|:..:
Yeast   406 IPDLLQFAADALVYYEQIDGHIS---KKFAEIDFQSKSEFQTFCSTYRKRIRDIIRLISCVELDL 467

  Fly   468 TYGYCEQWLQQRLRNAQIEADAEVKSGNVSCSVLDPVYLEWDALVSVLDGVLSRILLV------- 525
            ||    .||..||.|        ..|......||...:|  |..:....|.||:.::|
Yeast   468 TY----DWLNNRLNN--------YFSSPFGQQVLSSTFL--DHKLEPYLGALSQYMIVECFINGC 518

  Fly   526 --------------AERPSVPAGLRLL-EECLKLETINPLTYSILLSCISALFVFLSMSACQITA 575
                          .:..|:...|.:| .:.:.|....||   :|...|....:||:|....:..
Yeast   519 IRWKIWYPTGDDYDEKLDSILQKLEILSNQLIALNLREPL---LLKKQIQNFALFLTMLKDNVLF 580

  Fly   576 TNCVAMSGVSLLPRVLDKIFRALVMKPPN-ELEKVQAKS--AKNLRRHAASLLVKLAHKYPLLLL 637
            |             :|:||..:..|..|. .||:..|:|  .::||......|.::|...|..|.
Yeast   581 T-------------LLEKIITSATMDYPEINLEERGAESDAVRDLRYACGIELNRMALLMPESLK 632

  Fly   638 PVFEQINGHVELLLKEPGKHQLCRLMRTTLQEALILISNHFCDFERQTLFIEHIVQDKRTEWLAF 702
            .::..:...:..::.....|:     :.:.:..|::|
Yeast   633 KIYPDLESVIARIMPNLSYHE-----KISFKSFLLII---------------------------- 664

  Fly   703 GDALKSPLDFMS--FVGLDKPPIFAVEGAVTLQNRSRLLDALHVV---LGVVKRCTW-------- 754
              .|||.||...  |..:..|.:.|.....|:..    |..||..   ||:|:...:
Yeast   665 --VLKSSLDMKEERFAAIVDPELLAWSDKTTVVG----LSDLHWFMERLGIVQIAEYFQRRDIDE 723

  Fly   755 -------PDDPE---------RAQRGGFVIGCT---------------------ELGNPICRNPA 782
                   |.|.|         :..:..|.:..|                     :|..|
Yeast   724 NSDLLSIPIDDEGKELKSELTKRWQSLFPVRATRMFIHYSMQSIKTDEEFKMLQDLWRP------ 782

  Fly   783 TKHIVPLLSHVLSLMRVLNELFAPEALQALSE------GYRGIHGMMEHEKKLLMGICALPTDPL 841
              .|||:|.::..|:..|.....|:..:.|..      .|..|....|         ........
Yeast   783 --RIVPILPYITRLLYQLQSYHDPDNWKGLPTVVQSFVKYSTIERFWE---------AGASNKSK 836

  Fly   842 DTTIRSEPTAFEKMQTF------MMMVTEGCYHLMGSAGPSLGRDLYQLMGLSDAIVTNVF---- 896
            |..|.....|.:.::.|      ::..|.....|:.||..|||...|.|....|.::.::.
Yeast   837 DEFIDEHMKAMQTLRDFADSVGHIIRYTREYTLLVLSAISSLGSVFYLLDESPDLLLNSIAIFKP 901

  Fly   897 SRMDLVP---DYRLRPIIRVFFKPFVYSCPP----SFYDSVLVPLFAHLAPLMCERLTRRWIYIA 954
            ...::.|   .:..:.|:.:..:|.:..||.    .|..:.|..||..|..|:|::
Yeast   902 GSNEISPGVSTHGWKHIMNIAIRPILKGCPKDCLGKFMPAFLPKLFEILDLLLCQK--------- 957

  Fly   955 SLYESGQLDGEVND--------TQEVLEDQLNRTLTREYLDVLKIALVGGQIGADHVAAGANANS 1011
              :.|...|.::|.        |:|:||:.|.|.||..   |::|.:       |.|..| |||.
Yeast   958 --WSSHMNDMDMNPVPTDDDQMTEEILEENLLRQLTTV---VVRIVI-------DCVGQG-NANP 1009

  Fly  1012 NSVAMENEEHSMDSAPQSRAIQSALLSDIISDLGGKLLRNGLIGNYVLMTLLK----AIAWNDGM 1072
            ||.......|.|    :.|.|       |.:||.            .|...||    .|::.|..
Yeast  1010 NSAKSRLNNHQM----EMRKI-------IFNDLN------------TLAPFLKLLNHLISFKDTK 1051

  Fly  1073 CSMKAVNIAAPVMRFLAAEKLMDENKAVTAFT-AVLQGMQVH---------GQHEANQSGLVTLG 1127
            ||..::    .||:......|...|.....|| .|::.:.::         ..|||    |....
Yeast  1052 CSFNSI----LVMKCCLTSVLNQNNTVDEYFTFEVMKNLLLNVLCNSAFKDSFHEA----LYAFT 1108

  Fly  1128 VQFYELLRPQFPI-------------LSEVLQHIPSVNAADIQK------FDEKIAVAPVKGNKV 1173
            |.|..|.: ::|.             :.|:.:::.||:....|:      .|...:.:..:...|
Yeast  1109 VIFLTLCK-EYPSARAFLFEISNGYNIDELYRNLRSVDEYKTQRALMIDFIDWVKSTSGKEDGNV 1172

  Fly  1174 DRA---------KKDIFKKLTAQLVGRSVNQLFRHEVQIANLPPMQSHKAKGSM--------GTT 1221
            |.|         ::.|.||...:|:                    :.:|..|.|        |..
Yeast  1173 DHAGDERKRQEKREAILKKANERLI--------------------KKNKENGDMLDDPNIEDGAV 1217

  Fly  1222 ADIMDSN 1228
            .::.|.|
Yeast  1218 GNLFDDN 1224

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ranbp21	NP_608339.2	IBN_N	34..101	CDD:397745	15/69 (22%)
		Xpo1	116..274	CDD:462459	39/195 (20%)
		Exportin-5	319..1196	CDD:437105	196/1042 (19%)
MSN5	NP_010622.1	CRM1	23..>172	CDD:227432	39/156 (25%)
		Exportin-5	332..1186	CDD:437105	192/1024 (19%)