DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ranbp21 and Xpo6

DIOPT Version :9

Sequence 1:	NP_001285453.1	Gene:	Ranbp21 / 32970	FlyBaseID:	FBgn0031051	Length:	1241	Species:	Drosophila melanogaster
Sequence 2:	XP_017167830.1	Gene:	Xpo6 / 74204	MGIID:	2429950	Length:	1140	Species:	Mus musculus

Alignment Length:	1389	Identity:	271/1389 - (19%)
Similarity:	459/1389 - (33%)	Gaps:	444/1389 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly    10 LAAELAS--AIDLVMNPMTQQQARLEAYMAC---ERFKEESPM----CAQVG-----LFLASSPQ 60
            :|:|.||  |::.:|.         |.:..|   ||.:|...:    ..|||     |:..||.:
Mouse     1 MASEEASLRALESLMT---------EFFHDCTTNERKREIEELLNNFAQQVGAWRFCLYFLSSTR 56

  Fly    61 SNQQVRHFGLQLIEYTIKYRWNCITHEEKVYIKDNAIKMLNVGVGPAEDRSLLP--TKDALSRII 123
             |..|..:.|.:.|..|...|..:..::|:.|:....|:|      ......||  .::.|.::|
Mouse    57 -NDYVMMYSLTVFENLINKMWLGVPSQDKMEIRSCLPKLL------LAHHKTLPYFIRNKLCKVI 114

  Fly   124 VEMIKREWPQQWSDLLPELSQACTKGEAQTELVLLVFLRLVEDVALLQTIESNQRRKDMYQALNN 188
            |::.:::||..:.|....:.| ..:....|.|.|::.....|::|.        .|:|:..|...
Mouse   115 VDIGRQDWPMFYHDFFTNILQ-LIQSPVTTPLGLIMLKTTSEELAC--------PREDLSVARKE 170

  Fly   189 NMNDIFEFFLRLVEQHVTAFRETTRLCNYTKANAHSRVVEMVLLTLSGFVEWVSIQHIMS----- 248
            .:..:      |::|                       |:.||..|:|.:|.|..:|.::
Mouse   171 ELRKL------LLDQ-----------------------VQTVLGLLTGILETVWDKHSVTAATPP 206

  Fly   249 -------------------SNGKLMHF-LCILLNDKAFQCN-AAECLAQITNRKGQTKERKPLLQ 292
                               |:.||:|. :.||..:..:.|: |.||||.:.:       ..||..
Mouse   207 PSPTSGESGDLLSNLLQSPSSAKLLHQPIPILDVESEYVCSLALECLAHLFS-------WIPLSA 264

  Fly   293 LFNEEPLRYIYQASQIPADTSSTLAVEQHLNFLKKLLQVLNGMAQQLVALWGKDDATQRPVHLEV 357
            ......|..|:..::...||.:           :|:..| ||.:|..|       ..|....|.|
Mouse   265 SITPSLLTTIFHFARFGCDTRA-----------RKMASV-NGSSQNCV-------LGQERGRLGV 310

  Fly   358 L-LECLLLLVQHPSLGLSHGSALIWQLLLKHEPSSKDFAMVNYIPK--LIHTIAPRIVKLPYPAS 419
            | :.|:..|:....:.:.....|:...       .:.|.::..|.|  ..||:..|:.:|.
Mouse   311 LAMSCINELMSKNCVPMEFEEYLLRMF-------QQTFYLLQKITKDNNAHTVKSRLEELD---- 364

  Fly   420 ASSPAS-------LSTEAYIRLEHDSEEEYALYFFRCRTDFLEIF------RLATLVQ-PLVTYG 470
             .||.|       |..|:||       |::        ||||.:|      |:.:..| |:|
Mouse   365 -ESPGSEVKAERCLEAESYI-------EKF--------TDFLRLFVSVHLRRIESYSQFPVV--- 410

  Fly   471 YCEQWLQQRLRNAQIEADAEVKSGNVSCSVLDPVYLEW--------------------DALVSVL 515
               ::|....:....:...|   |..||..:..::|::                    ||||.:|
Mouse   411 ---EFLTLLFKYTFHQPTHE---GYFSCLDIWTLFLDYLTSKIKSRLGDKEAVLNRYEDALVLLL 469

  Fly   516 DGVLSRILLVAERPSVPAGLRLLEECL--------------KLETINPLTYSILLSCISALF--- 563
            ..||:||.....:..:.   .|.:|.|              .||.:..:...:.....|.||
Mouse   470 TEVLNRIQFRYNQAQLE---ELDDETLDDDQQTEWQRYLRQSLEVVAKVMELLPTHAFSTLFPVL 531

  Fly   564 -----VFLSMS----------ACQITATN------CVAMSGVSLLPRV-------LDKIFRALVM 600
                 |:|.:.          ...|||.|      |......|||..|       :..:|.|..
Mouse   532 QDNLEVYLGLQQFVVTSGSGHRLNITAENDCRRLHCSLRDLSSLLQAVGRLAEYFIGDVFAARF- 595

  Fly   601 KPPNELEKVQAKSAKNLRRHAASLLVKLAHKYPLLLLPVFEQINGHVE-LLLKEPGKHQLCRLM- 663
               |:...|..:..|.....:...|..:....|.:|.|  :.|:.|.: |...:...|.|.:..
Mouse   596 ---NDALTVVERLVKVTLYGSQIKLYNIETAVPSVLKP--DLIDVHAQSLAALQAYSHWLAQYCG 655

  Fly   664 ---RTTLQEALILISNHFCDFERQTLFIEHIVQDKRTEWLAFGDALKSPLDFMSFVGLDKPPIFA 725
               |...|:.:.|||.   ..:..|..|...||||         .|.|....:..:.....|:|.
Mouse   656 EAHRQNTQQFVTLIST---TMDAITPLISTKVQDK---------LLLSACHLLVSLATTVRPVFL 708

  Fly   726 VE--------GAVTLQNRSRLLDALHVV----LGVVKRCTWPDDPERAQRGGF-VIGCTELGNPI 777
            :.        .::...:..||.|...|:    |.......||:.||..|:... .|....|.:.:
Mouse   709 ISIPAVQKVFNSIIDASAQRLTDKAQVLVCRALSNTLLLPWPNLPESEQQWPLRSINHASLISAL 773

  Fly   778 CRN--------PATKHIVPL------LSHVLSLMRVLNELFAPEALQALSEGYRGIHGMMEHEKK 828
            .|:        .|.:..|||      :...||::..:.|..:.|:.::....|:.:      ::.
Mouse   774 SRDYHSLKPSATAPQRKVPLGDTKVIIHQTLSVLEDIVENISGESTKSRQICYQSL------QES 832

  Fly   829 LLMGICALPT--DPLDTTIRSEPTAFEKMQTFMMMVTEGCYHLMGSAGPSLGRDLYQLMGLSDAI 891
            :.:.:...|.  ...|.|        ::|.:|.:.:..|....||             :..::.|
Mouse   833 VQVSLALFPAFIHQSDVT--------DEMLSFFLTLFRGLRVQMG-------------VPFTEQI 876

  Fly   892 V---TNVFSRMDLVPDY------------RLRPIIRV-------FFKPFVYSCPPSFYDSVLVPL 934
            :   .|:|:|..|....            :...|::|       .||||:        .|::...
Mouse   877 IQTFLNMFTREQLAESILHEGSTGCRVVEKFLKILQVVVQEPGQVFKPFL--------PSIIALC 933

  Fly   935 FAHLAPLMCERLTRRWIYIASLYESGQLDGEVNDTQEVLEDQLNRTLTREYLDVLKIALVGGQIG 999
            ...:.|::.||.:                   .|.:..|.:.|.|||...:....|..::.
Mouse   934 MEQVYPIIAERPS-------------------PDVKAELFELLFRTLHHNWRYFFKSTVLA---- 975

  Fly  1000 ADHVAAGANANSNSVAMENEEHSMDSAPQSRAI-----QSALLSDIISDLGGKLLRNGLIGNYVL 1059
                         ||.....|..|::.||..||     ||.|..||      .|.:..|.....|
Mouse   976 -------------SVQRGIAEEQMENEPQFSAIMQAFGQSFLQPDI------HLFKQNLFYLETL 1021

  Fly  1060 MTLLKAIAWNDGMCSMKAVNIAAPVMRFLAAEKLMDENKAVTAFTAVLQGMQVHGQHEANQSGLV 1124
            .|..|..                        .|.:.....:..|..||..:.||..|:..|.
Mouse  1022 NTKQKLY------------------------HKKIFRTTMLFQFVNVLLQVLVHKSHDLLQE--- 1059

  Fly  1125 TLGVQFYELLRPQF-----PILSEVLQHIPSVNAADIQKFDEKIAVAPVKGNKVDRAKKDIFKKL 1184
            .:|:..|.:....|     ..|.|.|.....|:|      ::|..:.  :..|:||.....
Mouse  1060 EIGIAIYNMASVDFDGFFAAFLPEFLTSCDGVDA------NQKNVLG--RNFKMDRDLPSF---- 1112

  Fly  1185 TAQLVGRSVNQLFRHEVQIANLPP 1208
             .|.|.|.||.|..:.:...:|||
Mouse  1113 -TQNVHRLVNDLRYYRLCNDSLPP 1135

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ranbp21	NP_001285453.1	IBN_N	34..101	CDD:281761	19/78 (24%)
Ranbp21	NP_001285453.1	Xpo1	116..274	CDD:285575	34/183 (19%)
Xpo6	XP_017167830.1	IBN_N	31..96	CDD:197981	16/71 (23%)
Xpo6	XP_017167830.1	Xpo1	103..277	CDD:369848	42/218 (19%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5101
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900