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Protein Alignment Ranbp21 and XPO5

DIOPT Version :10

Sequence 1:	NP_608339.2	Gene:	Ranbp21 / 32970	FlyBaseID:	FBgn0031051	Length:	1241	Species:	Drosophila melanogaster
Sequence 2:	NP_065801.1	Gene:	XPO5 / 57510	HGNCID:	17675	Length:	1204	Species:	Homo sapiens

Alignment Length:	1253	Identity:	444/1253 - (35%)
Similarity:	709/1253 - (56%)	Gaps:	78/1253 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly     9 ALAAELASAIDLVMNPMTQQQARLEAYMACERFKEESPMCAQVGLFLASSPQSNQQVRHFGLQLI 73
            ||..:|..|:.::|:|.:.|:.||||...||.|||:.|:|...||.||...|. ..|||||||::
Human     8 ALCEQLVKAVTVMMDPNSTQRYRLEALKFCEEFKEKCPICVPCGLRLAEKTQV-AIVRHFGLQIL 71

  Fly    74 EYTIKYRWNCITHEEKVYIKDNAIKML-NVGVGPAEDRSLLPTKDALSRIIVEMIKREWPQQWSD 137
            |:.:|:|||.::..||||:|::.:::: |..:...|:.:.:  |||||||:||||||||||.|.|
Human    72 EHVVKFRWNGMSRLEKVYLKNSVMELIANGTLNILEEENHI--KDALSRIVVEMIKREWPQHWPD 134

  Fly   138 LLPELSQACTKGEAQTELVLLVFLRLVEDVALLQTIESNQRRKDMYQALNNNMNDIFEFFLRLVE 202
            :|.||.....:||.|||||:.:.|||.|||...||:.. |||:|:.|.|..||..||.|.|..::
Human   135 MLIELDTLSKQGETQTELVMFILLRLAEDVVTFQTLPP-QRRRDIQQTLTQNMERIFSFLLNTLQ 198

  Fly   203 QHVTAFRET-TRLCNYTKANAHSRVVEMVLLTLSGFVEWVSIQHIMSSNGKLMHFLCILLNDKAF 266
            ::|..:::. |.....:||.|:.||....|.||:|:::|||:.||.:.|.||:..||:|||::..
Human   199 ENVNKYQQVKTDTSQESKAQANCRVGVAALNTLAGYIDWVSMSHITAENCKLLEILCLLLNEQEL 263

  Fly   267 QCNAAECLAQITNRKGQTKERKPLLQLFNEEPLRYIYQASQIPADTSSTLAVEQHLNFLKKLLQV 331
            |..|||||....:|||:.::||||:.||.:..:.||..|:| .||...  .||:|..|||:|.||
Human   264 QLGAAECLLIAVSRKGKLEDRKPLMVLFGDVAMHYILSAAQ-TADGGG--LVEKHYVFLKRLCQV 325

  Fly   332 LNGMAQQLVALWGKDDATQRPVHLEVLLECLLLLVQHPSLGLSHGSALIWQLLLKHEPSSKDFAM 396
            |..:..||.||.|.|...:.|.:....||..|....|||..|...:.:.|..|.:||..|:|..:
Human   326 LCALGNQLCALLGADSDVETPSNFGKYLESFLAFTTHPSQFLRSSTQMTWGALFRHEILSRDPLL 390

  Fly   397 VNYIPKLIHTIAPRIVKLPYPASASSPASLSTEAYIRLEHDSEEEYALYFFRCRTDFLEIFRLAT 461
            :..|||.:......:||:.:|:...||:.    .|.|.:.||:|::..:|...|....|:.|||.
Human   391 LAIIPKYLRASMTNLVKMGFPSKTDSPSC----EYSRFDFDSDEDFNAFFNSSRAQQGEVMRLAC 451

  Fly   462 LVQPLVTYGYCEQWLQQRLRN----AQIEADAEVKSGNVS-CSVLDPVYLEWDALVSVLDGVLSR 521
            .:.|..::....:||:.:|..    ..:.:.:.|.:|..| |||..|.:::|:|:...|:.|:::
Human   452 RLDPKTSFQMAGEWLKYQLSTFLDAGSVNSCSAVGTGEGSLCSVFSPSFVQWEAMTLFLESVITQ 516

  Fly   522 ILLVAERPSVPA--GLRLLEECLKLETINPLTYSILLSCISALFVFLSMSACQITATNCVAMSGV 584
            :.....|..:|.  |:.||:..|..:|.:||..|.:|:.:||||.|::...
Human   517 MFRTLNREEIPVNDGIELLQMVLNFDTKDPLILSCVLTNVSALFPFVTYRP-------------- 567

  Fly   585 SLLPRVLDKIFRALVMKPPNELEKVQAKSAKNLRRHAASLLVKLAHKYPLLLLPVFEQINGHVEL 649
            ..||:|..|:|.::..:...|.:..:.::.:|:||||.|.::|:...||.|:||.|:.:..||:.
Human   568 EFLPQVFSKLFSSVTFETVEESKAPRTRAVRNVRRHACSSIIKMCRDYPQLVLPNFDMLYNHVKQ 632

  Fly   650 LLKEPGKHQLCRLMRTTLQEALILISNHFCDFERQTLFIEHIVQDKRTEWLAFG-DALKSPLD-F 712
            ||.  .:..|.::.:..|.|||:||||.|.::|||.:|:|.::....:.||:.. ..:.|.:| |
Human   633 LLS--NELLLTQMEKCALMEALVLISNQFKNYERQKVFLEELMAPVASIWLSQDMHRVLSDVDAF 695

  Fly   713 MSFVGLDK---PPIFAVEGAVTLQNRSRLLDALHVVLGVVKRCTWPDDPERAQRGGFVIGCTELG 774
            :::||.|:   .|  .:|....| ||:|:...::.:||||||..||.|.|.|:.||||:|.|..|
Human   696 IAYVGTDQKSCDP--GLEDPCGL-NRARMSFCVYSILGVVKRTCWPTDLEEAKAGGFVVGYTSSG 757

  Fly   775 NPICRNPATKHIVPLLSHVLSLMRVLNELFAPEALQALSEGYRGIHGMMEHEKKLLMGICALPTD 839
            |||.|||.|:.|:.||.::|:|:|..|.|:|||.|..::|.:.....|::.||..::|   ||..
Human   758 NPIFRNPCTEQILKLLDNLLALIRTHNTLYAPEMLAKMAEPFTKALDMLDAEKSAILG---LPQP 819

  Fly   840 PLDTTIRSEP---TAFEKMQTFMMMVTEGCYHLMGSAGPSLGRDLYQLMGLSDAIVTNVFSRMDL 901
            .|:  :...|   |..|:||.|...:.|.|:|::|.||||:.:|.|.:..|:..::::.|..::.
Human   820 LLE--LNDSPVFKTVLERMQRFFSTLYENCFHILGKAGPSMQQDFYTVEDLATQLLSSAFVNLNN 882

  Fly   902 VPDYRLRPIIRVFFKPFVYSCPPSFYDSVLVPLFAHLAPLMCERLTRRWIYI---ASLYESGQLD 963
            :|||||||::|||.||.|..|||..|::::.|:...|...:..||:::|..|   :.|....:..
Human   883 IPDYRLRPMLRVFVKPLVLFCPPEHYEALVSPILGPLFTYLHMRLSQKWQVINQRSLLCGEDEAA 947

  Fly   964 GEVNDTQEVLEDQLNRTLTREYLDVLKIALVGGQIGADHVAAGANANSNSVAMENEEHSMDSAPQ 1028
            .|..::||:||:||.|.||||.:|::.:..|..: ||||.:|......:...|..|
Human   948 DENPESQEMLEEQLVRMLTREVMDLITVCCVSKK-GADHSSAPPADGDDEEMMATE--------- 1002

  Fly  1029 SRAIQSALLSDIISDLGGKLLRNGLIGNYVLMTLLKAIAWNDGM-CSMKAVNIAAPVMRFLAAEK 1092
              ...||:..  ::|||..|:::..:...:|:|...::||.|.: |......:..|:::.:.:..
Human  1003 --VTPSAMAE--LTDLGKCLMKHEDVCTALLITAFNSLAWKDTLSCQRTTSQLCWPLLKQVLSGT 1063

  Fly  1093 LMDENKAVT-AFTAVLQGMQVHGQHEANQSGLVTLGVQFYELLRPQFPILSEVLQHIPSVNAADI 1156
            |:.:  ||| .||:||:|:|:||||:...:.||.|..|.||.|||::..:..|::.||.:....:
Human  1064 LLAD--AVTWLFTSVLKGLQMHGQHDGCMASLVHLAFQIYEALRPRYLEIRAVMEQIPEIQKDSL 1126

  Fly  1157 QKFDEKIAVAPVKGNKVDRAKKDIFKKLTAQLVGRSVNQLFRHEVQIANLPPMQSHKAKGSMGTT 1221
            .:||.|: :.|......|:.:||.||:|.|..:|:.:.:.||.||.|.|||.: ..|.|..:.|
Human  1127 DQFDCKL-LNPSLQKVADKRRKDQFKRLIAGCIGKPLGEQFRKEVHIKNLPSL-FKKTKPMLET- 1188

  Fly  1222 ADIMDSNQNASLARLFGP 1239
             :::| |....||.:|.|
Human  1189 -EVLD-NDGGGLATIFEP 1204

Known Domains:

Indicated by green bases in alignment.

Software error:

Illegal division by zero at /www/www.flyrnai.org/docroot/cgi-bin/DRSC_prot_align.pl line 592.

For help, please send mail to the webmaster (ritg@hms.harvard.edu), giving this error message and the time and date of the error.