Protein Alignment Ranbp21 and xpo1b

DIOPT Version :10

• Sequence 1: NP_608339.2
• Gene: Ranbp21 / 32970
• FlyBaseID: FBgn0031051
• Length: 1241
• Species: Drosophila melanogaster
• Sequence 2: XP_073784620.1
• Gene: xpo1b / 561138
• ZFINID: ZDB-GENE-070530-6
• Length: 1082
• Species: Danio rerio
• Alignment Length: 1156
• Identity: 215/1156 - (18%)
• Similarity: 425/1156 - (36%)
• Gaps: 246/1156 - (21%)

  Fly     1 MSQHGGTEALAAELASAIDLVMNPMT--------QQQARLEAYMACERFKEESPMCAQVGLFLAS 57
            ::.|...:.|.......|:|:.|.:.        ||:...|   .....||......:|...|..
Zfish    19 LADHAARQLLDFNQKLDINLLDNVVNCLYHGVGPQQRMAQE---VLTHLKEHPDAWTRVDTILEF 80

  Fly    58 SPQSNQQVRHFGLQLIEYTIKYRWNCITHEE----KVYIKDNAIKMLNVGVGPAEDRSLLPTKDA 118
            |  .|...:::.||::|..||.||..:...:    |.|:....||..:......:::..:   ..
Zfish    81 S--QNMNTKYYALQILETVIKTRWKILPRNQCEGIKKYVVGLIIKTSSDAANVEKEKVYI---GK 140

  Fly   119 LSRIIVEMIKREWPQQWSDLLPELSQACTKGEAQTELVLLVFLRLVEDVALLQTIESNQ-RRKDM 182
            |:.|:|:::|:|||:.|...:.::..|....|:..:..:::...|.|:|....:.:..| :.|.:
Zfish   141 LNMILVQILKQEWPKHWPTFISDIVGASRTSESLCQNNMIILKLLSEEVFDFSSGQMTQVKAKHL 205

  Fly   183 YQALNNNMNDIFEFFLRLVEQHVTAFRETTRLCNYTKANA-HSRVVEMVLLTLSGFVEWVSIQHI 246
            ..::.|..:.||:                  ||.:...|: ::.:|...|.||..|:.|:.:.:|
Zfish   206 KDSMCNEFSQIFQ------------------LCQFVMENSQNAPLVHATLETLLRFLNWIPLGYI 252

  Fly   247 MSSNGKLMHFLCI-LLNDKAFQCNAAECLAQITNRKGQTKERKPLLQLFNEEPLRYIYQASQIPA 310
            ..:  ||:..|.. .||...|:....:||.:|........|.    |..|...|..:.....:|.
Zfish   253 FET--KLISTLVYKFLNVPMFRNVTLKCLTEIAGVSVSQYEE----QFVNLFTLTMMQLKQMLPL 311

  Fly   311 DTSSTLAV----EQHLNFLKKLLQVLNGMAQ---QLVALWGKDDATQRPVHL-EVLLECL--LLL 365
            :|:..||.    :...||::.|...|....:   ||:         ::.::| |.|:|.|  :||
Zfish   312 NTNIRLAYANGKDDEQNFIQNLSLFLCTFLKEHGQLI---------EKRLNLRETLMEALHYMLL 367

  Fly   366 VQHP------SLGLSHGSALIWQLLLKHEPSSKDFAMVN-------------YIPKLIHTIAPRI 411
            |...      .:.|.:.:.|..:|..:...|:....:::             |:|.|..
Zfish   368 VSEVEETEIFKICLEYWNHLAAELYRESPFSTSTSPLLSGSQHFDVPPRRQLYLPVLSK------ 426

  Fly   412 VKLPYPASASSPASLSTEAYIRLEHDSEEEYALYFFRCRTDFLEIFR--LATLVQ-PLVTYGYCE 473
            |:|...:..:.|     |..:.:|:|..|  .:..|...||.:.:::  ..|||. ..:.|...|
Zfish   427 VRLLMVSRMAKP-----EEVLVVENDQGE--VVREFMKDTDSINLYKNMRETLVYLTHLDYADTE 484

  Fly   474 QWLQQRLRNAQIEADAEVKSGNVSC----SVLDPVYLEWDA--LVSVLDGVL------------- 519
            :.:.::|.|.....:...|:.|..|    |:...::.|.:.  ||:|:..:|
Zfish   485 RIMTEKLHNQVNGTEWSWKNLNTLCWAIGSISGAMHEEDEKRFLVTVIKDLLGLCEQKRGKDNKA 549

  Fly   520 ---SRILLVAERPSVPAGLRLLEECLKLETINPLTYSILLSCISALFVFLSMS-------ACQI- 573
               |.|:.:..:  .|..||             ..:..|.:.::.||.|:..:       ||..
Zfish   550 IIASNIMYIVGQ--YPRFLR-------------AHWKFLKTVVNKLFEFMHETHDGVQDMACDTF 599

  Fly   574 --TATNC----VAMSGVSLLP---RVLDKIFRALVMKPPNELE--------KVQAKSAKNLRRHA 621
              .|..|    |.:....::|   .:|:.|...:....|.::.        .:.|::.:.::.|
Zfish   600 IKIAQKCRRHFVQVQVGEVMPFIDEILNNINTIICDLQPQQVHTFYEAVGYMIGAQTDQAVQEH- 663

  Fly   622 ASLLVKLAHKYPLLLLP------VFEQINGHVELLLKEPGKHQLCRLMRTTLQEALILISNHFCD 680
                  |..||  :|||      :.:|...:|::|.......||..:::|.:: |...:.:.|
Zfish   664 ------LIEKY--MLLPNQVWDSIIQQATKNVDILKDPETVKQLGSILKTNVR-ACKAVGHPF-- 717

  Fly   681 FERQTLFIEHIVQDKRTEWLAFGDALKSPLDFMSFVGLDKPPIFAVEGAVTLQNRSRLLDALHVV 745
                .:.:..|..|....:....:.:.:.:.....:...:|.|.::        |:...:.|.::
Zfish   718 ----VIQLGRIYLDMLNVYKCLSENISAAIQTNGEMVTKQPLIRSM--------RTVKRETLKLI 770

  Fly   746 LGVVKRCTWPDDPERAQRGGFVIGCTELGNPICRNPATKHIVPLLSHVL-SLMRVLNELFAPEAL 809
            .|.|.|   .:||:       ::|             ...:.|||..|| ...|.:.....||.|
Zfish   771 SGWVSR---SNDPQ-------MVG-------------ENFVPPLLDAVLIDYQRNVPAAREPEVL 812

  Fly   810 QALSEGYRGIHGMMEHE-KKLLMGICALPTDPLDTTIRSEPTAFEKMQTFMMMVTEGCYHLMGSA 873
            ..::.....:.|.:..| .::...:.....:.::......|.........:..|...|:....:.
Zfish   813 STMATIVNKLGGHITGEIPQIFDAVFECTLNMINKDFEEYPEHRTHFFYLLQAVNSHCFPAFLAI 877

  Fly   874 GPSLGRDLYQLMGLSDAIVTNVFSRMDLVPDYRLRPIIRVFFKPFVY--SCPPSFYDSVLVPLFA 936
            .|:      |...:.|:|:......|..|.|..|: |:....:....  :...|||.:....:..
Zfish   878 PPA------QFKLVLDSIIWAFKHTMRNVADTGLQ-ILYTLLQNVAQEEAAAQSFYQTYFCDILQ 935

  Fly   937 HLAPLMCER-----LTRR---WIYIASLYESGQLDGEVNDTQEVLEDQLNRTLTREYL-DVLKIA 992
            |:..::.:.     ||..   ..|:.:|.|.|::...:|.:..|    .|:...:||: ::||.|
Zfish   936 HIFSVVTDTSHTAGLTMHASILAYMFNLVEEGKISTTLNPSNPV----NNQVFIQEYVANLLKSA 996

  Fly   993 ---LVGGQIGADHVAAGANANSNSVAMENEEHSMDSAPQSRAIQSALLSDI 1040
               |...|:.. .|....:.|.:..|.  :||..|...|.:.......||:
Zfish   997 FPHLQDAQVKV-FVTGLFSLNQDIAAF--KEHLRDFLVQIKEFAGEDTSDL 1044

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ranbp21	NP_608339.2	IBN_N	34..101	CDD:397745	17/70 (24%)
		Xpo1	116..274	CDD:462459	34/160 (21%)
		Exportin-5	319..1196	CDD:437105	145/819 (18%)
xpo1b	XP_073784620.1	None