DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ranbp21 and Xpo6

DIOPT Version :9

Sequence 1:	NP_001285453.1	Gene:	Ranbp21 / 32970	FlyBaseID:	FBgn0031051	Length:	1241	Species:	Drosophila melanogaster
Sequence 2:	NP_001011935.2	Gene:	Xpo6 / 293476	RGDID:	1311491	Length:	1125	Species:	Rattus norvegicus

Alignment Length:	1407	Identity:	271/1407 - (19%)
Similarity:	445/1407 - (31%)	Gaps:	495/1407 - (35%)

- Green bases have known domain annotations that are detailed below.

  Fly    10 LAAELAS--AIDLVMNPMTQQQARLEAYMAC---ERFKEESPM----CAQVG-----LFLASSPQ 60
            :|:|.||  |::.:|.         |.:..|   ||.:|...:    ..|||     |:..||.:
  Rat     1 MASEDASLRALESLMT---------EFFHDCTTNERKREIEELLNNFAQQVGAWRFCLYFLSSTR 56

  Fly    61 SNQQVRHFGLQLIEYTIKYRWNCITHEEKVYIKDNAIKMLNVGVGPAEDRSLLP--TKDALSRII 123
             |..|..:.|.:.|..|...|..:..::|:.|:....|:|      ......||  .::.|.::|
  Rat    57 -NDYVMMYSLTVFENLINKMWLGVPSQDKMEIRSCLPKLL------LAHHKTLPYFIRNKLCKVI 114

  Fly   124 VEMIKREWPQQWSDLLPELSQACTKGEAQTELVLLVFLRLVEDVALLQTIESNQRRKDMYQALNN 188
            |::.:::||..:.|....:.| ..:....|.|.|::.....|::|.        .|:|:..|...
  Rat   115 VDIGRQDWPMFYHDFFTNILQ-LIQSPVTTPLGLIMLKTTSEELAC--------PREDLSVARKE 170

  Fly   189 NMNDIFEFFLRLVEQHVTAFRETTRLCNYTKANAHSRVVEMVLLTLSGFVEWVSIQHIMS----- 248
            .:..:      |::|                       |:.||..|:|.:|.|..:|.::
  Rat   171 ELRKL------LLDQ-----------------------VQTVLGLLTGILETVWDKHSVTAATPP 206

  Fly   249 -------------------SNGKLMHF-LCILLNDKAFQCN-AAECLAQITN------------- 279
                               |:.||:|. :.||..:..:.|: |.||||.:.:
  Rat   207 PSPTSGESGDLLSNLLQSPSSAKLLHQPIPILDVESEYVCSLALECLAHLFSWIPLSASITPSLL 271

  Fly   280 ---------------RK-------------GQTKERKPLLQL---------------FNEEPLRY 301
                           ||             ||.:.|..:|.:               |.|..||.
  Rat   272 TTIFHFARFGCDTRARKMASVNGSSQNCVLGQERGRLGVLAMSCINELMSKNCVPMEFEEYLLRM 336

  Fly   302 ----IYQASQIPADTSSTLA-----------VEQHLNFLKKLLQVLNGMAQQLVALWGKDDATQR 351
                .|...:|..|.::...           ||:..:||:..:.         |.|...:..:|.
  Rat   337 FQQTFYLLQKITKDNNAHTVKSRLEELDESYVEKFTDFLRLFVS---------VHLRRIESYSQF 392

  Fly   352 PVHLEVLLECLLLLVQ---HPSLGLSHGSAL-IWQLLL-------KHEPSSKDFAMVNYIPKLIH 405
            ||     ||.|.||.:   |......:.|.| ||.|.|       |.....|:..:..|...|:.
  Rat   393 PV-----LEFLTLLFKYTFHQPTHEGYFSCLDIWTLFLDYLTSKIKSRLGDKEAVLNRYEDALVL 452

  Fly   406 TIAPRIVKLPYPASASSPASLSTEAYIRLEHDSEEEYALYFFRCRTDFLEIFRLATLVQPLVTYG 470
            .:...:.::.:..:.:....|..|.   |:.|.:.|:..|.    ...||:  :|.:::.|.|:.
  Rat   453 LLTEVLNRIQFRYNQAQLEELDDET---LDDDQQTEWQRYL----RQSLEV--VAKVMELLPTHA 508

  Fly   471 YCEQW--LQQRLR--------------NAQIEADAEVKSGNVSCSVLDPVYLEWDALVSVLDGV- 518
            :...:  ||..|.              ..::...||.....:.||:.|        |.|:|..|
  Rat   509 FSTLFPVLQDNLEVYLGLQQFVVTSGSGHRLNITAENDCRRLHCSLRD--------LSSLLQAVG 565

  Fly   519 --------------LSRILLVAERPSVPAGLRLLEECLKLETINPLTYSIL-----------LSC 558
                          .|..|.|.||   ...:.|....:||..|.....|:|           |:.
  Rat   566 RLAEYFTGDVFAARFSDALTVVER---LVKVTLYGSQIKLYNIETAVPSVLKPDLIDVHAQSLAA 627

  Fly   559 ISALFVFLSMSACQITATNCVAMSGVSLLPRVLDKIFRALVMKPPNELEKVQAKSAKNLRRHAAS 623
            :.|...:|:....:....|  ....|:|:...:|.|       .|....|||.|    |...|..
  Rat   628 LQAYSHWLAQYCSEAHRQN--TQQFVTLISTTMDAI-------TPLISTKVQDK----LLLSACH 679

  Fly   624 LLVKLAHKY-PLLLL------PVFEQINGHVELLLKEPGKHQLCRLMRTTLQEALILISNHFCDF 681
            |||.||... |:.|:      .||..|.......|.:..:..:||.:..||   |:...|
  Rat   680 LLVSLATTVRPVFLISIPAMQKVFNSIIDASAQRLTDKAQVLVCRALSNTL---LLPWPN----- 736

  Fly   682 ERQTLFIEHIVQDKRTEWLAFGDALKSPLDFMSFVGLDKPPIFAVEGAVTLQNRSRLLD----AL 742
                      :.:...:|     .|:| ::..|.:........:::.:.....|...||    .:
  Rat   737 ----------LPESEQQW-----PLRS-INHASLISALSRDYHSLKPSAAAPQRKMPLDDTKVII 785

  Fly   743 HVVLGVVKRCTWPDDPERAQRGGFVIGCTELGNPICRN-------------PATKHIVPLLSHVL 794
            |..|.|     :.|..|.      :.|.:.....||..             ||..|...:...:|
  Rat   786 HQTLSV-----FEDIVEN------ISGESTKSRQICYQSLQESVQVSLALFPAFIHQSDVTDEML 839

  Fly   795 SLMRVLNELFAPEALQALSEGYRGIHGMMEHEKKLLMGICALPTDPLDTTIRSEPTAFEKMQTFM 859
            |....|               :||:        ::.||:               |...:.:|||:
  Rat   840 SFFLTL---------------FRGL--------RVQMGV---------------PFTEQIIQTFL 866

  Fly   860 MMVT-----EGCYHLMGSAGPSLGRDLYQLMGLSDAIVTNVFSRMDLVPDYRLRPIIR---VFFK 916
            .|.|     |...| .||.|               ..|...|.::       |:.:::   ..||
  Rat   867 NMFTREQLAESILH-EGSTG---------------CRVVEKFLKI-------LQVVVQEPGQVFK 908

  Fly   917 PFVYSCPPSFYDSVLVPLFAHLAPLMCERLTRRWIYIASLYESGQLDGEVNDTQEVLEDQLNRTL 981
            ||:        .|::......:.|::.||.:                   .|.:..|.:.|.|||
  Rat   909 PFL--------PSIIALCMEQVYPIIAERPS-------------------PDVKAELFELLFRTL 946

  Fly   982 TREYLDVLKIALVGGQIGADHVAAGANANSNSVAMENEEHSMDSAPQSRAI-----QSALLSDII 1041
            ...:....|..::.                 ||.....|..|::.||..||     ||.|..||
  Rat   947 HHNWRYFFKSTVLA-----------------SVQRGIAEEQMENEPQFSAIMQAFGQSFLQPDI- 993

  Fly  1042 SDLGGKLLRNGLIGNYVLMTLLKAIAWNDGMCSMKAVNIAAPVMRFLAAEKLMDENKAVTAFTAV 1106
                 .|.:..|.....|.|..|..                        .|.:.....:..|..|
  Rat   994 -----HLFKQNLFYLETLNTKQKLY------------------------HKKIFRTTMLFQFVNV 1029

  Fly  1107 LQGMQVHGQHEANQSGLVTLGVQFYELLRPQF-----PILSEVLQHIPSVNAADIQKFDEKIAVA 1166
            |..:.||..|:..|.   .:|:..|.:....|     ..|.|.|.....|:|      ::|..:.
  Rat  1030 LLQVLVHKSHDLLQE---EIGIAIYNMASVDFDGFFAAFLPEFLTSCDGVDA------NQKNVLG 1085

  Fly  1167 PVKGNKVDRAKKDIFKKLTAQLVGRSVNQLFRHEVQIANLPP 1208
              :..|:||.....     .|.|.|.||.|..:.:...:|||
  Rat  1086 --RNFKMDRDLPSF-----TQNVHRLVNDLRYYRLCNDSLPP 1120

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ranbp21	NP_001285453.1	IBN_N	34..101	CDD:281761	19/78 (24%)
Ranbp21	NP_001285453.1	Xpo1	116..274	CDD:285575	34/183 (19%)
Xpo6	NP_001011935.2	IBN_N	31..96	CDD:197981	16/71 (23%)
Xpo6	NP_001011935.2	Xpo1	103..277	CDD:285575	38/211 (18%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5101
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900