DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ranbp21 and SPAC328.01c

DIOPT Version :9

Sequence 1:	NP_001285453.1	Gene:	Ranbp21 / 32970	FlyBaseID:	FBgn0031051	Length:	1241	Species:	Drosophila melanogaster
Sequence 2:	NP_594202.2	Gene:	SPAC328.01c / 2542592	PomBaseID:	SPAC328.01c	Length:	1234	Species:	Schizosaccharomyces pombe

Alignment Length:	1369	Identity:	290/1369 - (21%)
Similarity:	518/1369 - (37%)	Gaps:	285/1369 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly    12 AELASAIDLVMNPMTQQQARLEAYMACERFKE--ESPMCAQVGLFLASSPQSNQQ---------- 64
            :.:..|:::|.:|.:.::.|..|....:..|:  .||..|...|.|      |:|
pombe     7 SNILQALNVVHSPESSRETRFSAQQLLDELKDSYSSPSVAIQLLEL------NEQAFSSLGCKLD 65

  Fly    65 ---VRHFGLQLIEYTIKYRWNCITHEEKVYIKDNAIKMLNVGVGPAEDRSLLP---TKDALSRII 123
               |:||.|.|.|.::...|...:::||..:.....|:      ..||.:||.   .:..|:.:.
pombe    66 IHIVQHFSLSLFETSVGMNWKSFSNKEKESVTSFLCKI------SLEDNNLLSVHFVRSKLASVF 124

  Fly   124 VEMIKREWPQQWSDLLPELSQACTKGEAQ-TELVLLVFLRLVEDV-----------------ALL 170
            :|:.||:|...|.:......|:......| .:|..|:...::||:                 ||:
pombe   125 IEIAKRDWYNTWREEFDSFLQSLWSLSLQHRQLSSLILRGIMEDLYQYDDPVASLRSHILFNALI 189

  Fly   171 QTIESNQRRKDMYQA--------LNNNMNDIFEFFLRLVEQHVTAFRETTRLCNYTKANAHSRVV 227
            ..:.|:.....:|.:        .:||...:..:...|..|      :....|
pombe   190 SILSSSSTLHKLYPSGLPYSVTIPSNNEGWLIRWGNALESQ------DDALEC------------ 236

  Fly   228 EMVLLTLSGFVEWVSIQHIMSSNGKLMHFLC-ILLNDKAF-QCNAAECLAQITNRKGQTKERKPL 290
               |......:.||:...|..:|  ::..:| ||:....| :.:|.:|:.....|..:..:  ||
pombe   237 ---LKCFKSCLSWVATDSIREAN--IVSHICQILVQGPIFLKTHAIDCIYICVTRTMEIDD--PL 294

  Fly   291 LQLFNE--EP-----LRYIYQAS--QIPADTSSTLAVEQHLNFLKKLLQVLNGMAQQLVALWGKD 346
            .::..|  .|     |..:|.|:  .|...|.|:...|..|  ||||.:.:..:.|     :...
pombe   295 WEIVEEMLSPSSLYTLHQVYTATSESINIKTLSSTTPEYIL--LKKLSETIVALGQ-----YNYL 352

  Fly   347 DATQRP----VHLEVLLECLLLLVQHPSLGLSHGSALIWQLLLKHEPSSKDFAMVNYIPKLIHTI 407
            |:.:|.    ..|:.....:|.:::||||.:|..|...|.|.|:....||........|:|:...
pombe   353 DSNRRKCIKLTSLDTYSLLVLEIMKHPSLLISAISQHFWVLALRDPIISKHEKFQIVYPELLSIA 417

  Fly   408 APRIVKLPYPASASSPASLSTEAYIRLEHDSEEEYALYFFRC---RTDFLEIFRLATLVQPLVTY 469
            :.|:::.........|.| :|..|  |:.|.|...|::.| |   |....:|.||...:.|:.:.
pombe   418 SERLLRFEDAVVELIPES-ATAKY--LQEDVEGVSAVHSF-CGNFRRFMFDIVRLTVSITPIESL 478

  Fly   470 GYCEQWLQQRLRNAQIEADAEVKSGNVSCSVLDPVYLEWDALVSVLDGVLSRILLVAERPS-VPA 533
                .|:|.|.::..:....:::|.....|...|:||..|...|.::..|..:....|..| .||
pombe   479 ----NWIQNRFQSTVLGNMEDIQSQTEFFSKTSPLYLTMDVGFSTIEAFLHGVTRWNENTSDDPA 539

  Fly   534 GLRLLEE-----CLKLETINPLTYSILLSCISALFVFLSMSACQITATNCVAMSGVSLLPRVLDK 593
            ...::.:     |.:|..||.....::...||.|.:|          |:.:|....:||..||:|
pombe   540 TYEIILQNLFLWCKQLVEINFKDPMLITRLISVLVLF----------TSILARENTTLLGVVLEK 594

  Fly   594 IFRALVMKPP------NELEKVQAKSAKNLRRHAASLLVKLAHKYPLLLLPVFEQINGHVELLLK 652
            |..|:.....      ::::|:     ..:|......||:|....|..|:.:|:|:...::
pombe   595 IISAVTYDNTSASYGFSDVQKI-----NEMRSRCCFELVRLGELMPNPLMNIFDQLQSIID---- 650

  Fly   653 EPGKHQLCRLMRTTLQEALIL-----ISNHFCD--FERQTLFIEHIVQDKRTEWLAFGDALKSPL 710
                 ||......|..|.::|     :...|.|  .|.:..:.|.:|......||.....:.||:
pombe   651 -----QLDNATTLTGSEIVMLKTFLFVITQFSDVNIEVKNEYFEKLVGPVVKTWLDVQPPVNSPM 710

  Fly   711 DFMSFVGLD--------KPPI------FAVEG-AVTLQNRSRLLDALHVVLGVVKRCTWPDDPER 760
            :|::.:|..        |.|.      |.::. |.:.|:.          |...::..||
pombe   711 EFLNHIGFPQMAEYLSAKYPYNADYTQFELDADAASYQSN----------LETGRKWLWP----- 760

  Fly   761 AQRGGFVIGCTELG---NPICRNPATKHIVP----------------LLSHVLSLMRVLNELFAP 806
                   |.|  ||   ...|.|   |||.|                ::.::|.|:..|:..:.|
pombe   761 -------IKC--LGRFCEATCSN---KHIHPSEFEGQKNLWQVILPNVVPNLLKLVEQLHCCYEP 813

  Fly   807 EALQALSEGYRGIHGMMEHEKKL-----LMGICALPTDP-LDTTIRSEPTAFEKMQT---FMMMV 862
            ..:..|     |:|.....:|.:     |.|:..:..:. |:.:.:.:.:|.:.:.:   |:..:
pombe   814 SFISGL-----GMHNSSILQKSIVERFWLHGVSQISKNQFLEESYKMDVSANKLIHSFGHFLRRL 873

  Fly   863 TEGCYHLMGSAGPSLGRDLYQLMGLSDAIVTNVFSRMDLVPDYRLRPIIRVFFKPFVYSCPPSFY 927
            .|.||:.:.|. ..||:..:.:.|||...:|..||....:..::...::.|..||:..:||....
pombe   874 REYCYYAIASF-MRLGQAFFCVPGLSKQFLTAFFSHAAGLSLHQWTSMVNVVIKPYCVNCPAELR 937

  Fly   928 DSVLVPLFAHLAPLMCERLTRRWIYIAS----LYESGQLDGEVND-TQEVLEDQLNRTLTREYLD 987
            |..|:||...|...:..:|...|..|..    :.|..:..||.:| ::|::|:.|.|.||  |..
pombe   938 DECLLPLLPALLSELDHKLVSEWRRINDRGLLVEEDAEETGEDDDLSEEMIEESLLRHLT--YAT 1000

  Fly   988 VLKIALVGGQIGADHVAAGANANSNSVAMENEEHSMDSAPQSRAIQSALLSDIISDLGGKLLRNG 1052
            ...|.....||  ....:.:|.:|:.:..|..|..:.            ||:.:.|       |.
pombe  1001 AKLITETFLQI--TPTQSRSNVSSSLIGKETVEGPVK------------LSEYVLD-------NA 1044

  Fly  1053 LIGNYVLMTLLKAIAWNDGMCSMKAVNIAAPVMRFLAAEK---LMDENKAVTAFTAVLQGMQVHG 1114
            :|...:|.||...:..:|.......||....:...|.:|:   |:.|......|.:|:  :.:|.
pombe  1045 IICEPLLCTLCHLLVIHDSRTVGLVVNAFLAITPLLVSEQAHSLVREFICQQVFQSVI--LAIHD 1107

  Fly  1115 QH-EANQSGLVTLGVQFYELLRPQFPILSEVLQHIPSVNAADIQKFDEKIAVAPVKGNKVDRAKK 1178
            .: |:.||..:.|..   .:|.....|.....|.:.|:.|...|:     .:.|...||...|..
pombe  1108 PYFESMQSDFIRLAC---IILSYSQGITDSAFQLLASIPALANQE-----NLVPAFFNKFREAST 1164

  Fly  1179 -DIFKKLTAQLV--GRSVNQLFRHEVQIANLPPMQSHKAKGSMGTTA-------DIMDSNQNASL 1233
             .|.|.|..:|:  ||.|.:..|..|..|.|........|....:.:       |::..:::..|
pombe  1165 LKIQKALLTRLLNSGRIVPRTDRRAVNAAILDVSAKEMLKRFEKSVSLQDEQKNDVLSRDEDTGL 1229

  Fly  1234 ARLF 1237
            |.||
pombe  1230 ANLF 1233

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ranbp21	NP_001285453.1	IBN_N	34..101	CDD:281761	19/81 (23%)
Ranbp21	NP_001285453.1	Xpo1	116..274	CDD:285575	31/185 (17%)
SPAC328.01c	NP_594202.2	Xpo1	114..280	CDD:285575	31/188 (16%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	94	1.000	Domainoid score	I1962
eggNOG	1	0.900	-	-		E1_COG5101
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	121	1.000	Inparanoid score	I1488
OMA	1	1.010	-	-		QHG55404
OrthoFinder	1	1.000	-	-		FOG0003520
OrthoInspector	1	1.000	-	-		oto100952
orthoMCL	1	0.900	-	-		OOG6_103801
Panther	1	1.100	-	-	LDO	PTHR11223
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1937
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	11	10.900