DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ranbp21 and XPO6

DIOPT Version :9

Sequence 1:	NP_001285453.1	Gene:	Ranbp21 / 32970	FlyBaseID:	FBgn0031051	Length:	1241	Species:	Drosophila melanogaster
Sequence 2:	NP_055986.1	Gene:	XPO6 / 23214	HGNCID:	19733	Length:	1125	Species:	Homo sapiens

Alignment Length:	1396	Identity:	270/1396 - (19%)
Similarity:	468/1396 - (33%)	Gaps:	476/1396 - (34%)

- Green bases have known domain annotations that are detailed below.

  Fly    10 LAAELAS--AIDLVMNPMTQQQARLEAYMAC---ERFKEESPM----CAQVG-----LFLASSPQ 60
            :|:|.||  |::.:|.         |.:..|   ||.:|...:    ..|:|     |:..||.:
Human     1 MASEEASLRALESLMT---------EFFHDCTTNERKREIEELLNNFAQQIGAWRFCLYFLSSTR 56

  Fly    61 SNQQVRHFGLQLIEYTIKYRWNCITHEEKVYIKDNAIKMLNVGVGPAEDRSLLP--TKDALSRII 123
             |..|..:.|.:.|..|...|..:..::|:.|:....|:|      ......||  .::.|.::|
Human    57 -NDYVMMYSLTVFENLINKMWLGVPSQDKMEIRSCLPKLL------LAHHKTLPYFIRNKLCKVI 114

  Fly   124 VEMIKREWPQQWSDLLPELSQACTKGEAQTELVLLVFLRLVEDVALLQTIESNQRRKDMYQALNN 188
            |::.:::||..:.|....:.| ..:....|.|.|::.....|::|.        .|:|:..|...
Human   115 VDIGRQDWPMFYHDFFTNILQ-LIQSPVTTPLGLIMLKTTSEELAC--------PREDLSVARKE 170

  Fly   189 NMNDIFEFFLRLVEQHVTAFRETTRLCNYTKANAHSRVVEMVLLTLSGFVEWVSIQHIMSS---- 249
            .:..:      |::|                       |:.||..|:|.:|.|..:|.:::
Human   171 ELRKL------LLDQ-----------------------VQTVLGLLTGILETVWDKHSVTAATPP 206

  Fly   250 -------NGKLMHFL------CILLN--------DKAFQCN-AAECLAQITNRKGQTKERKPLLQ 292
                   :|.|:..|      ..|||        :..:.|: |.||||.:.:       ..||..
Human   207 PSPTSGESGDLLSNLLQSPSSAKLLNQPIPILDVESEYICSLALECLAHLFS-------WIPLSA 264

  Fly   293 LFNEEPLRYIYQASQIPADTSSTLAVEQHLNFLKKLLQVLNGMAQQLVALWGKDDATQRPVHLEV 357
            ......|..|:..::...|..:           :|:..| ||.:|..|       :.|....|.|
Human   265 SITPSLLTTIFHFARFGCDIRA-----------RKMASV-NGSSQNCV-------SGQERGRLGV 310

  Fly   358 L-LECLLLLVQHPSLGLSHGSALIWQLLLKHEPSSKDFAMVNYIPK--LIHTIAPRIVKLPYPAS 419
            | :.|:..|:....:.:.....|:...       .:.|.::..|.|  ..||:..|:.:|
Human   311 LAMSCINELMSKNCVPMEFEEYLLRMF-------QQTFYLLQKITKDNNAHTVKSRLEEL----- 363

  Fly   420 ASSPASLSTEAYIRLEHDSEEEYALYFFRCRTDFLEIF------RLATLVQ-PLVTYGYCEQWLQ 477
                    .|:||       |::        ||||.:|      |:.:..| |:|      ::|.
Human   364 --------DESYI-------EKF--------TDFLRLFVSVHLRRIESYSQFPVV------EFLT 399

  Fly   478 QRLRNAQIEADAEVKSGNVSCSVLDPVYLEW--------------------DALVSVLDGVLSRI 522
            ...:....:...|   |..||..:..::|::                    ||||.:|..||:||
Human   400 LLFKYTFHQPTHE---GYFSCLDIWTLFLDYLTSKIKSRLGDKEAVLNRYEDALVLLLTEVLNRI 461

  Fly   523 LLVAERPSVPAGLRLLEECL--------------KLETINPLTYSILLSCISALF--------VF 565
            .....:..:.   .|.:|.|              .||.:..:...:.....|.||        |:
Human   462 QFRYNQAQLE---ELDDETLDDDQQTEWQRYLRQSLEVVAKVMELLPTHAFSTLFPVLQDNLEVY 523

  Fly   566 LSMS----------ACQITATN------CVAMSGVSLLPRV-------LDKIFRALVMKPPNELE 607
            |.:.          ...|||.|      |......|||..|       :..:|.|..    |:..
Human   524 LGLQQFIVTSGSGHRLNITAENDCRRLHCSLRDLSSLLQAVGRLAEYFIGDVFAARF----NDAL 584

  Fly   608 KVQAKSAKNLRRHAASLLVKLAHKYPLLLLPVFEQINGHVE-LLLKEPGKH---QLC-RLMRTTL 667
            .|..:..|.....:...|..:....|.:|.|  :.|:.|.: |...:...|   |.| .:.|...
Human   585 TVVERLVKVTLYGSQIKLYNIETAVPSVLKP--DLIDVHAQSLAALQAYSHWLAQYCSEVHRQNT 647

  Fly   668 QEALILISNHFCDFERQTLFIEHIVQDKRTEWLAFGDALKSPLDFMSFVGLDKPPIFAVE----- 727
            |:.:.|||.   ..:..|..|...||||         .|.|....:..:.....|:|.:.
Human   648 QQFVTLIST---TMDAITPLISTKVQDK---------LLLSACHLLVSLATTVRPVFLISIPAVQ 700

  Fly   728 ---GAVTLQNRSRLLDALHVV----LGVVKRCTWPDDPERAQRGGFVIGCTELGNPICRNPATKH 785
               ..:|..:..||:|...|:    |..:....||:.||..|:.           |:
Human   701 KVFNRITDASALRLVDKAQVLVCRALSNILLLPWPNLPENEQQW-----------PV-------- 746

  Fly   786 IVPLLSHVLSLMRVLNELFAPEALQALSEGYRGIH-GMMEHEKKLLMGICALPTDPLDTTIRSEP 849
                        |.:|.   ...:.|||..||.:. ..:..::|:          |||.|
Human   747 ------------RSINH---ASLISALSRDYRNLKPSAVAPQRKM----------PLDDT----- 781

  Fly   850 TAFEKMQTFMMMVTEGCYHLMGSAGPSLGRDLYQLMGLSDAIVTNVFSRMDLVPDYRLRPIIRVF 914
                |:                        .::|.:.:.:.||.|:...     ..:.|.|
Human   782 ----KL------------------------IIHQTLSVLEDIVENISGE-----STKSRQI---- 809

  Fly   915 FKPFVYSCPPSFYDSV-----LVPLFAHLAPLMCERLTRRWIYIASLYESGQLDGEVNDTQEVLE 974
                   |..|..:||     |.|.|.|.:.:..|.|:    :..:|:...::...|..|:::::
Human   810 -------CYQSLQESVQVSLALFPAFIHQSDVTDEMLS----FFLTLFRGLRVQMGVPFTEQIIQ 863

  Fly   975 DQLNRTLTRE-------------------YLDVLKIAL-VGGQIGADHVAAGANANSNSVAMENE 1019
            ..|| ..|||                   :|.:|::.: ..||:....:     .:..::.||..
Human   864 TFLN-MFTREQLAESILHEGSTGCRVVEKFLKILQVVVQEPGQVFKPFL-----PSIIALCMEQV 922

  Fly  1020 EHSMDSAPQSRAIQSALLSDIISDLGGKLLRNGLIGNYVLMTLLKAIAWNDGMCSMKAVNIAAPV 1084
            ...:...|.         .|:.::|...|.|. |..|           |.....|    .:.|.|
Human   923 YPIIAERPS---------PDVKAELFELLFRT-LHHN-----------WRYFFKS----TVLASV 962

  Fly  1085 MRFLAAEKLMDENKAVTAFTAVLQGMQVHGQHEANQSGLVTLGVQFYELLRPQFPILSEVLQHIP 1149
            .|.:|.|::.:|.:    |:|:   ||..||                ..|:|...:..:.|.::.
Human   963 QRGIAEEQMENEPQ----FSAI---MQAFGQ----------------SFLQPDIHLFKQNLFYLE 1004

  Fly  1150 SVNAADIQKFDEKIAVAPVKGNKVDR-AKKDIFKKLTAQLVGRSVNQLFRHEVQIANLPPMQSHK 1213
            ::|..  ||...|         |:.| |....|..:..|::....:.|.:.|:.|| :..|.|..
Human  1005 TLNTK--QKLYHK---------KIFRTAMLFQFVNVLLQVLVHKSHDLLQEEIGIA-IYNMASVD 1057

  Fly  1214 AKGSMG-------TTADIMDSNQNASLARLF 1237
            ..|...       |:.|.:|:||.:.|.|.|
Human  1058 FDGFFAAFLPEFLTSCDGVDANQKSVLGRNF 1088

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ranbp21	NP_001285453.1	IBN_N	34..101	CDD:281761	18/78 (23%)
Ranbp21	NP_001285453.1	Xpo1	116..274	CDD:285575	34/183 (19%)
XPO6	NP_055986.1	IBN_N	31..96	CDD:197981	15/71 (21%)
XPO6	NP_055986.1	Xpo1	103..253	CDD:369848	35/187 (19%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5101
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900