Protein Alignment Ranbp21 and Ranbp21

DIOPT Version :10

• Sequence 1: NP_608339.2
• Gene: Ranbp21 / 32970
• FlyBaseID: FBgn0031051
• Length: 1241
• Species: Drosophila melanogaster
• Sequence 2: XP_320637.4
• Gene: Ranbp21 / 1280771
• VectorBaseID: AGAMI1_011332
• Length: 1233
• Species: Anopheles gambiae
• Alignment Length: 1248
• Identity: 701/1248 - (56%)
• Similarity: 909/1248 - (72%)
• Gaps: 48/1248 - (3%)

  Fly    10 LAAELASAIDLVMNPMTQQQARLEAYMACERFKEESPMCAQVGLFLASSPQSNQQVRHFGLQLIE 74
            ||.|||.|:.:.|:|...||||::||:||||||:.||:|||.||.|.:.... ..||||||||:|
Mosquito    10 LANELARAVKITMDPEATQQARMDAYVACERFKDISPLCAQAGLSLVTGAYP-PIVRHFGLQLME 73

  Fly    75 YTIKYRWNCITHEEKVYIKDNAIKMLNVGVGPAEDRSLLPTKDALSRIIVEMIKREWPQQWSDLL 139
            :|:|:.||.|:.:||::||:||:|:|..|||.|:|:||...||.:||||||||||||||||:.||
Mosquito    74 HTVKFNWNSISQQEKIFIKENAMKLLQAGVGEAQDQSLAHIKDGVSRIIVEMIKREWPQQWTTLL 138

  Fly   140 PELSQACTKGEAQTELVLLVFLRLVEDVALLQTIESNQRRKDMYQALNNNMNDIFEFFLRLVEQH 204
            .|||.||::|.|||||||||||||||||||||||||||||||:||||..||::||.|||||:|.|
Mosquito   139 VELSDACSQGMAQTELVLLVFLRLVEDVALLQTIESNQRRKDIYQALTVNMSEIFTFFLRLIELH 203

  Fly   205 VTAFRETTRLCNYTKANAHSRVVEMVLLTLSGFVEWVSIQHIMSSNGKLMHFLCILLNDKAFQCN 269
            |..||..|...:..||:.|||||::.|.||:||||||||.|||::||:|:..|||||.|..||..
Mosquito   204 VGEFRSATTGGDEHKAHGHSRVVQVALQTLTGFVEWVSINHIMAANGRLLQILCILLTDVEFQQP 268

  Fly   270 AAECLAQITNRKGQTKERKPLLQLFNEEPLRYIYQASQIPADTSSTLAVEQHLNFLKKLLQVLNG 334
            |||||.|||||:||.|:|||||.||.:.|:.:.|||    |..:..|..|.:..|||||.|||.|
Mosquito   269 AAECLGQITNRRGQLKDRKPLLLLFEDAPVEHYYQA----ATQNERLETEAYYLFLKKLAQVLTG 329

  Fly   335 MAQQLVALWGKDDATQ-RPVHLEVLLECLLLLVQHPSLGLSHGSALIWQLLLKHEPSSKDFAMVN 398
            :|.||.|||||::... :|..|...|..:|:..:|.|..|:|.:||||..|||||..||:..::.
Mosquito   330 LASQLTALWGKEECQPIKPHCLATFLGTVLIFTRHASYSLAHPAALIWTTLLKHEQISKEHLVLE 394

  Fly   399 YIPKLIHTIAPRIVKLPYPASASSPASLSTEAYIRLEHDSEEEYALYFFRCRTDFLEIFRLATLV 463
            ||||:|..|.|:|:|:.||....:..::..:.:..|::|:|||:.::|||||||||||||.|||:
Mosquito   395 YIPKVIEVIGPKIIKVNYPVRRWTGITMHPQTFASLDYDAEEEWLVFFFRCRTDFLEIFRQATLI 459

  Fly   464 QPLVTYGYCEQWLQQRLRNAQIEADAEVKSGNVSCSVLDPVYLEWDALVSVLDGVLSRILLVAER 528
            .||||:.|||.||     ||.:...|.......:|||.||:|||||||.:.|||||||||:|.||
Mosquito   460 APLVTFSYCEHWL-----NAMLAKTASCDRSATACSVTDPLYLEWDALTNALDGVLSRILMVTER 519

  Fly   529 PSVPAGLRLLEECLKLETINPLTYSILLSCISALFVFLSMSACQITATNCVAMSGVSLLPRVLDK 593
            |||.|||||||||||:|:.:||..|::|||||:||||||||:|||||.|||||:||.||||||:|
Mosquito   520 PSVSAGLRLLEECLKVESNDPLVLSVMLSCISSLFVFLSMSSCQITAANCVAMTGVQLLPRVLEK 584

  Fly   594 IFRALVMKPPNELEKVQAKSAKNLRRHAASLLVKLAHKYPLLLLPVFEQINGHVELLLKEPGKHQ 658
            ||.:||.:...|....:..:.||||||||:|:||:||||||||||:|:|||..|:.|:.:|  .:
Mosquito   585 IFASLVFQELGETRHTRTVAVKNLRRHAAALMVKIAHKYPLLLLPIFDQINTSVKNLIVQP--ER 647

  Fly   659 LCRLMRTTLQEALILISNHFCDFERQTLFIEHIVQDKRTEWLAFGDAL----KSPLDFMSFVGLD 719
            |.::.:.||.|||:||||||||||||:.|:..:::|..:.|   |..|    |:...|:.:|||:
Mosquito   648 LSKVEQVTLLEALLLISNHFCDFERQSGFVAEVIRDGVSIW---GGLLVPVVKNAHTFIEYVGLN 709

  Fly   720 KPPI--FA--VEGAVTLQNRSRLLDALHVVLGVVKRCTWPDDPERAQRGGFVIGCTELGNPICRN 780
            :|.|  ||  ||....: ||.:|..||::||||:|||:|||||:|..|||||:..||.|||||||
Mosquito   710 RPAIEPFATTVEDPYNV-NRRQLTYALNLVLGVIKRCSWPDDPDRCSRGGFVVALTESGNPICRN 773

  Fly   781 PATKHIVPLLSHVLSLMRVLNELFAPEALQALSEGYRGIHGMMEHEKKLLMGICALPTDPLDTTI 845
            |||.|:||||.|:|||||.||||:.|:|||:.|:.:|..:||.|.|||.|:|:..:..||||.:.
Mosquito   774 PATSHVVPLLPHILSLMRCLNELWKPDALQSFSDSFRNANGMQESEKKQLLGVSPVLQDPLDPSQ 838

  Fly   846 RSEPTAFEKMQTFMMMVTEGCYHLMGSAGPSLGRDLYQLMGLSDAIVTNVFSRMDLVPDYRLRPI 910
            :..||||.:||||:..:.|.|||:|||||||||||||.|.|:::|||.:||:.::.|||:|||.|
Mosquito   839 KLPPTAFGRMQTFLAGIFEHCYHMMGSAGPSLGRDLYALPGIANAIVGSVFASLEYVPDFRLRTI 903

  Fly   911 IRVFFKPFVYSCPPSFYDSVLVPLFAHLAPLMCERLTRRWIYIASLYESGQLDGEVNDTQEVLED 975
            :|||.|||:|||||.|:::||:|:|||..|.|..|||.||.||.:|||||:|..:||||||||||
Mosquito   904 VRVFLKPFIYSCPPVFHEAVLLPIFAHFVPFMLTRLTARWHYITALYESGELGEDVNDTQEVLED 968

  Fly   976 QLNRTLTREYLDVLKIALVGGQIGADHVAAGANANSNSVA-----MENEEHSMDSAPQ--SRAIQ 1033
            .|||||||||:||||:||||..|       ...|||.|.|     |:.::.|||..||  :||.|
Mosquito   969 MLNRTLTREYIDVLKVALVGSTI-------DPTANSTSDATMAGGMDQDDQSMDGTPQALTRAAQ 1026

  Fly  1034 SALLSDIISDLGGKLLRNGLIGNYVLMTLLKAIAWNDGMCSMKAVNIAAPVMRFLAAEKLMDENK 1098
            ||:.|::|||||||||||....|.::||:|..::|||...|:||..::.|::||||||:|:.|..
Mosquito  1027 SAMTSEVISDLGGKLLRNQYTSNPIVMTVLSVLSWNDSNSSLKATLLSGPIIRFLAAEQLITEAL 1091

  Fly  1099 AVTAFTAVLQGMQVHGQHEANQSGLVTLGVQFYELLRPQFPILSEVLQHIPSVNAADIQKFDEKI 1163
            |.....|||:.:|:|||||:||:.|:|||||.||:|||:||.:.||||.||:|:|.||||.||||
Mosquito  1092 ASNIIIAVLKALQLHGQHESNQTSLITLGVQAYEILRPKFPNILEVLQQIPNVSAGDIQKLDEKI 1156

  Fly  1164 AVAPVKGNKVDRAKKDIFKKLTAQLVGRSVNQLFRHEVQIANL----PPMQSHKAKGSMGTTADI 1224
            :....||||:|:||||:|||:|..::||::.|..|.||:|.||    ||..:|:.     ...::
Mosquito  1157 SSGSTKGNKIDKAKKDLFKKITTNIIGRNIGQHGRKEVKILNLQPIVPPPNNHRP-----NAFNL 1216

  Fly  1225 MDSNQNASLARLF 1237
            ::|||...||.||
Mosquito  1217 IESNQETGLAHLF 1229

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ranbp21	NP_608339.2	IBN_N	34..101	CDD:397745	37/66 (56%)
		Xpo1	116..274	CDD:462459	111/157 (71%)
		Exportin-5	319..1196	CDD:437105	493/892 (55%)
Ranbp21	XP_320637.4	None