Protein Alignment Ranbp21 and Xpo1

DIOPT Version :10

• Sequence 1: NP_608339.2
• Gene: Ranbp21 / 32970
• FlyBaseID: FBgn0031051
• Length: 1241
• Species: Drosophila melanogaster
• Sequence 2: NP_001399335.1
• Gene: Xpo1 / 103573
• MGIID: 2144013
• Length: 1071
• Species: Mus musculus
• Alignment Length: 1136
• Identity: 212/1136 - (18%)
• Similarity: 397/1136 - (34%)
• Gaps: 339/1136 - (29%)

  Fly    18 IDLVMNPM-----TQQQARLEAYMACERFKEESPMCAQVGLFLASSPQSNQQVRHFGLQLIEYTI 77
            :|.|:|.:     .||:...|   .....||......:|...|..|  .|...:::|||::|..|
Mouse    28 LDNVVNCLYHGEGAQQRMAQE---VLTHLKEHPDAWTRVDTILEFS--QNMNTKYYGLQILENVI 87

  Fly    78 KYRWNCITHEEKVYIKDNAIKMLNVGVGPAEDRSLLPTKDA----LSRIIVEMIKREWPQQWSDL 138
            |.||..:...:...||...:.::   :..:.|.:.:..:..    |:.|:|:::|:|||:.|...
Mouse    88 KTRWKILPRNQCEGIKKYVVGLI---IKTSSDPTCVEKEKVYIGKLNMILVQILKQEWPKHWPTF 149

  Fly   139 LPELSQACTKGEAQTELVLLVFLRLVEDVALLQTIESNQ-RRKDMYQALNNNMNDIFEFFLRLVE 202
            :.::..|....|:..:..:::...|.|:|....:.:..| :.|.:..::.|..:.||:
Mouse   150 ISDIVGASRTSESLCQNNMVILKLLSEEVFDFSSGQITQVKAKHLKDSMCNEFSQIFQ------- 207

  Fly   203 QHVTAFRETTRLCNYTKANA-HSRVVEMVLLTLSGFVEWVSIQHIMSSNGKLMHFLCI-LLNDKA 265
                       ||.:...|: ::.:|...|.||..|:.|:.:.:|..:  ||:..|.. .||...
Mouse   208 -----------LCQFVMENSQNAPLVHATLETLLRFLNWIPLGYIFET--KLISTLIYKFLNVPM 259

  Fly   266 FQCNAAECLAQITNRKGQTKERKPLLQLFNEEPLRYIYQASQIPADTSSTLAVEQHLNFLKKLLQ 330
            |:..:.:||.:|........|.:                     .:|..||.:.|    ||::|.
Mouse   260 FRNVSLKCLTEIAGVSVSQYEEQ---------------------FETLFTLTMMQ----LKQMLP 299

  Fly   331 VLNGMAQQLVALWGKDDATQRPVHLEVLLECLLLLVQHPSLGLSHGSALIWQLLLKHEPSSKDFA 395
            :...:  :|....||||......:|.:.| |..|        ..||..|..:|.|:..
Mouse   300 LNTNI--RLAYSNGKDDEQNFIQNLSLFL-CTFL--------KEHGQLLEKRLNLREA------- 346

  Fly   396 MVNYIPKLIHTIAPRIVKLPYPASASSPASLSTEAYIRLEHDSEEEYALYFFRCRTDFLEIFRLA 460
                :.:.:|                         |:.|..:.||             .|||::.
Mouse   347 ----LMEALH-------------------------YMLLVSEVEE-------------TEIFKIC 369

  Fly   461 TLVQPLVTYGYCEQW---LQQRLRNAQIEADAE-VKSGNVSCSVLDP---VYLEWDALVSVLDGV 518
                       .|.|   ..:..|.:.....|. :.||:....: .|   :||.          |
Mouse   370 -----------LEYWNHLAAELYRESPFSTSASPLLSGSQHFDI-PPRRQLYLT----------V 412

  Fly   519 LSRI-LLVAERPSVPAGLRLLE--------ECLK-LETIN-------PLTYSILLSCISALFVFL 566
            ||:: ||:..|.:.|..:.::|        |.:| .::||       .|.|...|..:....:..
Mouse   413 LSKVRLLMVSRMAKPEEVLVVENDQGEVVREFMKDTDSINLYKNMRETLVYLTHLDYVDTEIIMT 477

  Fly   567 SMSACQITATN---------CVAMSGVS-LLPRVLDKIFRALVMKPPNELEKVQAKSAKNLRRHA 621
            .....|:..|.         |.|:..:| .:....:|.|...|:|  :.|...:.|..|:.:...
Mouse   478 KKLQNQVNGTEWSWKNLNTLCWAIGSISGAMHEEDEKRFLVTVIK--DLLGLCEQKRGKDNKAII 540

  Fly   622 ASLLVKLAHKYPLLLLPVFEQINGHVELLLKEPGKHQLCRLMRTTLQEALILISNHFCDFERQTL 686
            ||.::.:..:||..|       ..|.:.|.....|  |...|..|...    :.:..||     .
Mouse   541 ASNIMYIVGQYPRFL-------RAHWKFLKTVVNK--LFEFMHETHDG----VQDMACD-----T 587

  Fly   687 FIE-------HIVQDKRTEWLAFGDALKSPLDFMSFVGLDKPP---------IFAVEGAVTLQNR 735
            ||:       |.||.:..|.:.|.|.:   |:.::.:..|..|         :..:.||.|.|..
Mouse   588 FIKIAQKCRRHFVQVQVGEVMPFIDEI---LNNINTIICDLQPQQVHTFYEAVGYMIGAQTDQTV 649

  Fly   736 SRLLDALHVVL------GVVKRCTWP----DDPERAQRGGFVI-----GCTELGNPICRNPATKH 785
            ...|...:::|      .::::.|..    .|||..::.|.::     .|..:|:|.
Mouse   650 QEHLIEKYMLLPNQVWDSIIQQATKNVDILKDPETVKQLGSILKTNVRACKAVGHPF-------- 706

  Fly   786 IVPL---LSHVLSLMRVLNELFAPEALQALSEG------YRGIHGMMEHEKKLLMGICALPTDP- 840
            ::.|   ...:|::.:.|:|..: .|:||..|.      .|.:..:.....||:.|..:...||
Mouse   707 VIQLGRIYLDMLNVYKCLSENIS-AAIQANGEMVTKQPLIRSMRTVKRETLKLISGWVSRSNDPQ 770

  Fly   841 ----------LDTTI----RSEPTAFEKMQTFMMMVTEGCYHLMGSAGPSLGRDLYQLMGLSDAI 891
                      ||..:    |:.|.|.|......|.:      ::...|..:..::.|:.......
Mouse   771 MVAENFVPPLLDAVLIDYQRNVPAAREPEVLSTMAI------IVNKLGGHITAEIPQIFDAVFEC 829

  Fly   892 VTNVFSR-MDLVPDYR------LRPIIRVFFKPFVYSCPP------------------------- 924
            ..|:.:: .:..|::|      |:.:....|..|: :.||
Mouse   830 TLNMINKDFEEYPEHRTNFFLLLQAVNSHCFPAFL-AIPPAQFKLVLDSIIWAFKHTMRNVADTG 893

  Fly   925 -------------------SFYDSVLVPLFAHLAPLMCER-----LTRR---WIYIASLYESGQL 962
                               |||.:....:..|:..::.:.     ||..   ..|:.:|.|.|::
Mouse   894 LQILFTLLQNVAQEEAAAQSFYQTYFCDILQHIFSVVTDTSHTAGLTMHASILAYMFNLVEEGKI 958

  Fly   963 DGEVNDTQEVLEDQLNRTLTREYL-DVLKIA 992
            ...:|....|    .|:...::|: ::||.|
Mouse   959 STPLNPGNPV----NNQMFIQDYVANLLKSA 985

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ranbp21	NP_608339.2	IBN_N	34..101	CDD:397745	16/66 (24%)
		Xpo1	116..274	CDD:462459	34/164 (21%)
		Exportin-5	319..1196	CDD:437105	148/823 (18%)
Xpo1	NP_001399335.1	CRM1	15..1044	CDD:227432	212/1136 (19%)
		HEAT 1	217..240		6/22 (27%)
		HEAT 2	241..277		10/37 (27%)
		Necessary for interaction with Ran and nuclear export complex formation. /evidence=ECO:0000250	327..450		34/201 (17%)
		HEAT 3	354..472		30/152 (20%)
		Necessary for interaction with RANBP3. /evidence=ECO:0000250	411..481		15/79 (19%)
		HEAT 4	515..553		9/39 (23%)
		HEAT 5	560..597		9/47 (19%)
		HEAT 6	602..639		6/39 (15%)
		HEAT 7	775..813		7/43 (16%)
		HEAT 8	885..916		2/30 (7%)
		HEAT 9	917..954		5/36 (14%)
		HEAT 10	1002..1039