DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ranbp21 and exd3

DIOPT Version :9

Sequence 1:	NP_001285453.1	Gene:	Ranbp21 / 32970	FlyBaseID:	FBgn0031051	Length:	1241	Species:	Drosophila melanogaster
Sequence 2:	XP_031747378.1	Gene:	exd3 / 100494579	XenbaseID:	XB-GENE-6046956	Length:	755	Species:	Xenopus tropicalis

Alignment Length:	845	Identity:	160/845 - (18%)
Similarity:	270/845 - (31%)	Gaps:	303/845 - (35%)

- Green bases have known domain annotations that are detailed below.

  Fly   435 EHD-SEEEYALYFFRCRTDFLEIFR-----LATLVQPLVTY----------------------GY 471
            |.| ||...:|.....:.|.|:|.:     ::||.:|||..                      ..
Frog     8 EQDHSEILSSLQSLWAKKDVLQIRQVVGQLISTLEEPLVALLDLLEVTSTWKGKGNSLAVLIANE 72

  Fly   472 CEQWLQQ-----------RLRNAQIEADAEVKSGNVSCSVLDPVYLEWDALVSVLDGVLSRI--- 522
            .:|||:.           |||..|..|.:.|..|.: ..:|..:|...:|..:.|.|.::.:
Frog    73 FQQWLKANPDARQVKSGLRLRKLQGRALSLVSEGQL-LDLLSDMYRIAEADRAFLLGQVTHLHRS 136

  Fly   523 ------LLVAERPSVPAGLRLLEECLKLETINPLTYSILLSCISALFVFLSMSACQI-------T 574
                  .::|.|..:...|.|.|.|      .||.:....:.:.|.........|::       :
Frog   137 GKYKEAAIMATRLGLQPDLDLEEMC------TPLLFMERFNLVEAYVADYRELQCRLVQMLDGWS 195

  Fly   575 ATNCVAMSGVSLLPRVLDKIFRALVMKPPNELEKVQAKSAKNLRRHAASLLVKLAHKY---PLLL 636
            |:|..|.           |:.|..:..||.:.:|:..|:       .:.|..||..:|   |:|.
Frog   196 ASNFNAR-----------KVSRQYIGLPPVKPDKLNMKT-------LSRLAFKLLERYNLDPVLC 242

  Fly   637 LPVFEQIN-GHVELLL------KEPGKHQLCRLMRTT------LQEALILISNHFCDFERQTLFI 688
            ..:..|.: |.::.|:      |..........:::|      ||:.||.:...:.|......:.
Frog   243 TNLLNQRHLGTLKYLMYKRFVEKSMTHENWTDHVQSTVGQSRWLQDQLITLLVRYSDCATAGRWA 307

  Fly   689 EHIVQDKRTEWLAFGDALKSPLDFMSFVGLDKPPIFAVEGAVTLQNRSRLLDALHVVLGVVKRCT 753
            .|....|.|..||..|:|:.                     :::|::   |.|...|
Frog   308 LHFGLPKETLPLAVADSLED---------------------LSIQDQ---LSANENV-------- 340

  Fly   754 WPDDP------------------------------ERAQRGGFVIGCTELGNPICRNPATKHIVP 788
             ||||                              ||..:.|.|:|......|:. ....|..|.
Frog   341 -PDDPQTRKEHFYQLPIPRDKIHFLRSAGDLSVCRERVLKDGQVVGVDMEWRPMF-GGLGKQTVS 403

  Fly   789 LLSHVLSLMRVLNELFAPEALQALSEGYRGIHGMMEHEKKLL-----MGICALPTDPLDTTIRSE 848
            |:.     :.:..|:|..:.||..:.| .|.:|.....::|:     :.:||
Frog   404 LVQ-----LALREEVFLLDLLQLNAPG-AGANGTQRTREELIRFIKDLFLCA------------- 449

  Fly   849 PTAFEKMQTFMMMVTEGCYHLMG------SAGPS-LGRDLYQLMGLSDAIVTNVFSRMDLVPDYR 906
                        .:|:..|.::|      :..|. ||.: .|..|:.|  :..|..::..|| :|
Frog   450 ------------AITKLSYSVLGDIQNLEATDPEFLGLE-KQTRGILD--LYTVHKQLQRVP-HR 498

  Fly   907 LR----PIIRVFFKPFVYSCPPSFYDSVLVPLFAHLAPLMCER---LTRRWIYIASLYESGQL-- 962
            .|    |:      ..:...|||  :..|.|        ..|:   |..|.|....|.::.||
Frog   499 PRGKREPV------DVLADGPPS--EDGLAP--------QSEKGLSLLVRDILGKPLDKTEQLSN 547

  Fly   963 -DGEVNDTQEVLEDQLNRTLTREYLDVLKIALVGGQIGADHVAAGANANSNSVAMENEEHSMDSA 1026
             |......|::|....:.....|..|||:         .|....|.|.|.......:.:.:.:..
Frog   548 WDKRPLREQQILYAAADAYCLLEVYDVLR---------QDPARFGLNPNLQQCPKSDSKANPEKR 603

  Fly  1027 PQSR--AIQSALLSDIISDLGGK---------LLRNGL--IGNYVLMTLLKAIAWNDGMCSMKAV 1078
            |:.:  ..:...|.|..||.|.:         :..|.|  :|.|
Frog   604 PRPKNPGARRQNLPDTGSDTGAQPIPPRQFSVICDNMLQGLGRY--------------------- 647

  Fly  1079 NIAAPVMRFLAAEKLM----DENKAVTAFTAVLQGMQVHGQHEANQSG--LVTLGVQFYELLRPQ 1137
                  :|.|..:.||    ||::.....              |.:.|  ::|.|:. ||.||.|
Frog   648 ------LRCLGVDVLMLDNDDEHRKAAEI--------------ARRDGRVILTCGLP-YETLRSQ 691

Fly 1138 1137
Frog 692 691

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ranbp21	NP_001285453.1	IBN_N	34..101	CDD:281761
Ranbp21	NP_001285453.1	Xpo1	116..274	CDD:285575
exd3	XP_031747378.1	DnaQ_like_exo	361..577	CDD:415823	53/276 (19%)
		Rnd	<526..>636	CDD:223426	23/118 (19%)
		Mut7-C	636..>730	CDD:418587	19/98 (19%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	442	1.000	Domainoid score	I536
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	655	1.000	Inparanoid score	I774
OMA	1	1.010	-	-		QHG55404
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0003520
OrthoInspector	1	1.000	-	-		otm48142
Panther	1	1.100	-	-	O	PTHR11223
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X4056
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	9	9.070