DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Arp10 and ACTR8

DIOPT Version :9

Sequence 1:	NP_001285452.1	Gene:	Arp10 / 32969	FlyBaseID:	FBgn0031050	Length:	378	Species:	Drosophila melanogaster
Sequence 2:	NP_075050.3	Gene:	ACTR8 / 93973	HGNCID:	14672	Length:	624	Species:	Homo sapiens

Alignment Length:	390	Identity:	76/390 - (19%)
Similarity:	136/390 - (34%)	Gaps:	123/390 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly    75 KHLLVSPKERKF----VLVENVFGSTVLRETLARVLFVHFDVSSVLFVPVHLIALSTLAVPTALV 135
            |:|.:..|:.|:    :|:.:::....::| |..::.:....|.::.....:.|.....:.:..:
Human   218 KYLEIPLKDLKYYRCILLIPDIYNKQHVKE-LVNMILMKMGFSGIVVHQESVCATYGSGLSSTCI 281

  Fly   136 VDVGYSETSVMPVFSGVQIMAAFKDQSYGGSAI--------------HAE----------IKRQL 176
            ||||..:|||..|..||.........:||||.:              :.|          :.:.|
Human   282 VDVGDQKTSVCCVEDGVSHRNTRLCLAYGGSDVSRCFYWLMQRAGFPYRECQLTNKMDCLLLQHL 346

  Fly   177 VE---------SGVKE-----------SLLTESVLEDIKVRTCF--------------VTTMER- 206
            .|         ||:::           :||.:..|.|.|::...              :||::.
Human   347 KETFCHLDQDISGLQDHEFQIRHPDSPALLYQFRLGDEKLQAPMALFYPATFGIVGQKMTTLQHR 411

  Fly   207 ------------------------AKARAN-----------GD-ENQPTPAPD------------ 223
                                    |||.|:           || ..|.:..|:
Human   412 SQGDPEDPHDEHYLLATQSKQEQSAKATADRKSASKPIGFEGDLRGQSSDLPERLHSQEVDLGSA 476

  Fly   224 -VDYIVSDNDAVIQVPGLLRESAYEIMFEASNERDSLPHLILRSILDC--TLDVRRALVESVFLV 285
             .|.:::.||:...:..|:.......:||  .:...|...||.|| ||  :.|.::.:..|:.:|
Human   477 QGDGLMAGNDSEEALTALMSRKTAISLFE--GKALGLDKAILHSI-DCCSSDDTKKKMYSSILVV 538

  Fly   286 GGGSMVQGLLARLRQELQH-LLTEDPFYAERFHGELQFKFFNAVGKQNFTAWLGGALCGATDLIQ 349
            |||.|..    :.::.||| :|.:.|....|....:..............||.|||:....|..|
Human   539 GGGLMFH----KAQEFLQHRILNKMPPSFRRIIENVDVITRPKDMDPRLIAWKGGAVLACLDTTQ 599

Fly 350 349
Human 600 599

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Arp10	NP_001285452.1	ACTIN	11..340	CDD:214592	72/379 (19%)
Arp10	NP_001285452.1	NBD_sugar-kinase_HSP70_actin	12..367	CDD:302596	76/390 (19%)
ACTR8	NP_075050.3	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..29
		NBD_sugar-kinase_HSP70_actin	162..619	CDD:388382	76/390 (19%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	430..462		7/31 (23%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5277
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900