DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Arp10 and ACTR10

DIOPT Version :9

Sequence 1:	NP_001285452.1	Gene:	Arp10 / 32969	FlyBaseID:	FBgn0031050	Length:	378	Species:	Drosophila melanogaster
Sequence 2:	XP_011535262.1	Gene:	ACTR10 / 55860	HGNCID:	17372	Length:	424	Species:	Homo sapiens

Alignment Length:	407	Identity:	161/407 - (39%)
Similarity:	246/407 - (60%)	Gaps:	39/407 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MPIYESVMQ--EKPPIVLDIGTAYTKLGFAAEAYPRKIMPTEVVMTTTGIRK--RLFDYD-TPEE 60
            ||:||.:..  ||..:|:|:|.|:||.|||.|..||.|:|:  |:...|:.|  |:..|: ..||
Human     1 MPLYEGLGSGGEKTAVVIDLGEAFTKCGFAGETGPRCIIPS--VIKRAGMPKPVRVVQYNINTEE 63

  Fly    61 LYDQLVDFLQTIFFKHLLVSPKERKFVLVENVFGSTVLRETLARVLFVHFDVSSVLFVPVHLIAL 125
            ||..|.:|:..::|:||||:|::|:.|::|:|...:..||||.||||.:|:|.|||..|.||:||
Human    64 LYSYLKEFIHILYFRHLLVNPRDRRVVIIESVLCPSHFRETLTRVLFKYFEVPSVLLAPSHLMAL 128

  Fly   126 STLAVPTALVVDVGYSETSVMPVFSGVQIMAAFKDQSYGGSAIHAEIKRQLVE------SGVKES 184
            .||.:.:|:|:|.||.|:.|:|::.|:.::..:.....||.|:|.|::.||:|      |..||.
Human   129 LTLGINSAMVLDCGYRESLVLPIYEGIPVLNCWGALPLGGKALHKELETQLLEQCTVDTSVAKEQ 193

  Fly   185 LL-------TESVLEDI-------KVRTCFVTTMER------AKARANGDENQPTPAPDVDYIVS 229
            .|       .|.|||||       |.|||||:.::|      ||...:|:..:|:|.|:|||.:
Human   194 SLPSVMGSVPEGVLEDIKGLLFFLKARTCFVSDLKRGLKIQAAKFNIDGNNERPSPPPNVDYPL- 257

  Fly   230 DNDAVIQVPGLLRESAYEIMFEASNERDSLPHLILRSILDCTLDVRRALVESVFLVGGGSMVQGL 294
            |.:.::.:.|.:|:|..||:||..||..|:..|||.|::.|.:|.|:.|.|::.::||.||:.|.
Human   258 DGEKILHILGSIRDSVVEILFEQDNEEQSVATLILDSLIQCPIDTRKQLAENLVVIGGTSMLPGF 322

  Fly   295 LARLRQELQHLLTEDPFYAERFHGELQFKFFNAVGKQNFTAWLGGALCGA-TDLIQTRSLVKETY 358
            |.||..|:::|: |.|.|.:.. |...|:......|.|..||||||:.|| .|::.:||:.||.|
Human   323 LHRLLAEIRYLV-EKPKYKKAL-GTKTFRIHTPPAKANCVAWLGGAIFGALQDILGSRSVSKEYY 385

  Fly   359 LKSEHVPDWSNLCDNRP 375
            .::..:|||.:|  |.|
Human   386 NQTGRIPDWCSL--NNP 400

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Arp10	NP_001285452.1	ACTIN	11..340	CDD:214592	140/357 (39%)
Arp10	NP_001285452.1	NBD_sugar-kinase_HSP70_actin	12..367	CDD:302596	150/384 (39%)
ACTR10	XP_011535262.1	NBD_sugar-kinase_HSP70_actin	12..389	CDD:302596	151/381 (40%)
ACTR10	XP_011535262.1	Actin	14..395	CDD:278451	151/385 (39%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165152305
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5277
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H10220
Inparanoid	1	1.050	277	1.000	Inparanoid score	I2957
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG56110
OrthoDB	1	1.010	-	-		D431718at33208
OrthoFinder	1	1.000	-	-		FOG0005826
OrthoInspector	1	1.000	-	-		oto88399
orthoMCL	1	0.900	-	-		OOG6_104680
Panther	1	1.100	-	-	LDO	PTHR11937
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R5702
SonicParanoid	1	1.000	-	-		X6314
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	15	14.800