Protein Alignment Arp10 and ACTL6B

DIOPT Version :9

• Sequence 1: NP_001285452.1
• Gene: Arp10 / 32969
• FlyBaseID: FBgn0031050
• Length: 378
• Species: Drosophila melanogaster
• Sequence 2: NP_057272.1
• Gene: ACTL6B / 51412
• HGNCID: 160
• Length: 426
• Species: Homo sapiens
• Alignment Length: 426
• Identity: 82/426 - (19%)
• Similarity: 155/426 - (36%)
• Gaps: 107/426 - (25%)

  Fly    14 IVLDIGTAYTKLGFAAEAYPRKIMPTEVVMTTT----GI--------RKRLFDYDT-----PEE- 60
            :|.|||:...:.|:|.|..|:...||.|.:...    |:        :.::|..||     |.:
Human    14 LVFDIGSFSVRAGYAGEDCPKADFPTTVGLLAAEEGGGLELEGDKEKKGKIFHIDTNALHVPRDG 78

  Fly    61 ------LYDQLVD-------FLQTIFFKHLLVSPKERKFVLVENVFGSTVLRETLARVLFVHFDV 112
                  |.:.:::       .|...:.||:...|.....::.|..:.:...||.|..::|..:::
Human    79 AEVMSPLKNGMIEDWECFRAILDHTYSKHVKSEPNLHPVLMSEAPWNTRAKREKLTELMFEQYNI 143

  Fly   113 SSVLFVPVHLIALSTLAVPTALVVDVGYSETSVMPVFSGVQIMAAFKDQSYGGSAIHAEIKRQLV 177
            .:.......::........|.||:|.|.:.|:.:||..|..:..........|..|..:.:....
Human   144 PAFFLCKTAVLTAFANGRSTGLVLDSGATHTTAIPVHDGYVLQQGIVKSPLAGDFISMQCRELFQ 208

  Fly   178 ESGV------------------------KESL----------LTESVLEDIKVRTCFVTTMERAK 208
            |..:                        ||.|          :...|::|.:.....|:.
Human   209 EMAIDIIPPYMIAAKEPVREGAPPNWKKKEKLPQVSKSWHNYMCNEVIQDFQASVLQVSD----- 268

  Fly   209 ARANGDENQPTPAPDVDYIVSDNDAVIQVP-------GLLRESAYEIMFEASNERD-------SL 259
              :..||......|.|.|         ::|       |..|....|.:|:.||.:.       .:
Human   269 --SPYDEQVAAQMPTVHY---------EMPNGYNTDYGAERLRIPEGLFDPSNVKGLSGNTMLGV 322

  Fly   260 PHLILRSILDCTLDVRRALVESVFLVGGGSMVQGLLARLRQELQHLLTEDPFYAERFHGELQFKF 324
            .|::..||..|.:|:|..|..||.:.||.:::||...||.:||          :::....::.|.
Human   323 GHVVTTSIGMCDIDIRPGLYGSVIVTGGNTLLQGFTDRLNREL----------SQKTPPSMRLKL 377

  Fly   325 F--NAVGKQNFTAWLGGALCGATDLIQTRSLVKETY 358
            .  |:..::.|:.|:||::..:....|...:.|:.|
Human   378 IASNSTMERKFSPWIGGSILASLGTFQQMWISKQEY 413

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Arp10	NP_001285452.1	ACTIN	11..340	CDD:214592	78/406 (19%)
		NBD_sugar-kinase_HSP70_actin	12..367	CDD:302596	82/426 (19%)
ACTL6B	NP_057272.1	Actin	11..426	CDD:394979	82/426 (19%)
		Essential for mediating its function in dendritic development, may contribute to neuronal-specific targeting. /evidence=ECO:0000250|UniProtKB:Q99MR0	39..82		7/42 (17%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5277
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900