DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Arp10 and POTEE

DIOPT Version :9

Sequence 1:NP_001285452.1 Gene:Arp10 / 32969 FlyBaseID:FBgn0031050 Length:378 Species:Drosophila melanogaster
Sequence 2:NP_001077007.1 Gene:POTEE / 445582 HGNCID:33895 Length:1075 Species:Homo sapiens


Alignment Length:379 Identity:80/379 - (21%)
Similarity:153/379 - (40%) Gaps:52/379 - (13%)


- Green bases have known domain annotations that are detailed below.


  Fly    14 IVLDIGTAYTKLGFAAEAYPRKIMPTEV------------------VMTTTGIRKRLFDYDTPEE 60
            :|:|.|:...|.|||.:..||.:.|:.|                  |......::.:.....|.|
Human   708 LVIDNGSGMCKAGFAGDDAPRAVFPSIVGRPRQQGMMGGMHQKESYVGKEAQSKRGILTLKYPME 772

  Fly    61 -----LYDQLVDFLQTIFFKHLLVSPKERKFVLVENVFGSTVLRETLARVLFVHFDVSSVLFVPV 120
                 .:|.:.......|:..|.|:|:|...:|.|........||.:.:::|..|: :..::|.:
Human   773 HGIITNWDDMEKIWHHTFYNELRVAPEEHPILLTEAPLNPKANREKMTQIMFETFN-TPAMYVAI 836

  Fly   121 HLI-ALSTLAVPTALVVDVGYSETSVMPVFSGVQIMAAFKDQSYGGSAIHAEIKRQLVESGVKES 184
            ..: :|.|....|.:|:|.|...|..:|::.|..:..|.......|..:...:.:.|.|.|.:.:
Human   837 QAVPSLYTSGRTTGIVMDSGDGVTHTVPIYEGNALPHATLRLDLAGRELPDYLMKILTERGYRFT 901

  Fly   185 LLTE-SVLEDIKVRTCFVT---TMERAKARANGDENQPTPAPDVDYIVSDNDAVIQVPGLLRESA 245
            .:.| .::.|||.:.|:|.   ..|.|.|.::....:....||...|...|:         |...
Human   902 TMAEREIVRDIKEKLCYVALDFEQEMATAASSSSLEKSYELPDGQVITIGNE---------RFRC 957

  Fly   246 YEIMFE---ASNERDSLPHLILRSILDCTLDVRRALVESVFLVGGGSMVQGLLARLRQELQHLLT 307
            .|.:|:   ...|...:......||:...:|:|:.|..:..|.||.:|..|:..|:::|:..|..
Human   958 PEALFQPCFLGMESCGIHETTFNSIMKSDVDIRKDLYTNTVLSGGTTMYPGMAHRMQKEIAALAP 1022

  Fly   308 EDPFYAERFHGELQFKFFNAVGKQNFTAWLGGALCGATDLIQTRSLVKETYLKS 361
                      ..::.:.. |..|:.::.|:||::..:....|...:.|:.|.:|
Human  1023 ----------SMMKIRII-APPKRKYSVWVGGSILASLSTFQQMWISKQEYDES 1065

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Arp10NP_001285452.1 ACTIN 11..340 CDD:214592 75/356 (21%)
NBD_sugar-kinase_HSP70_actin 12..367 CDD:302596 80/379 (21%)
POTEENP_001077007.1 Ank_4 143..193 CDD:290365
ANK 167..292 CDD:238125
ANK 1 172..201
ANK repeat 174..203 CDD:293786
Ank_2 177..269 CDD:289560
ANK repeat 205..236 CDD:293786
ANK 2 205..234
ANK 233..357 CDD:238125
ANK repeat 238..269 CDD:293786
ANK 3 238..267
Ank_2 243..335 CDD:289560
ANK repeat 271..302 CDD:293786
ANK 4 271..300
ANK repeat 304..335 CDD:293786
ANK 5 304..333
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 369..530
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 544..599
NBD_sugar-kinase_HSP70_actin 701..1075 CDD:302596 80/379 (21%)
Actin-like 702..1075 80/379 (21%)
ACTIN 705..1075 CDD:214592 80/379 (21%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_COG5277
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
21.810

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