DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Arp10 and Actl11

DIOPT Version :9

Sequence 1:	NP_001285452.1	Gene:	Arp10 / 32969	FlyBaseID:	FBgn0031050	Length:	378	Species:	Drosophila melanogaster
Sequence 2:	NP_001019959.2	Gene:	Actl11 / 316000	RGDID:	1310036	Length:	1218	Species:	Rattus norvegicus

Alignment Length:	393	Identity:	97/393 - (24%)
Similarity:	159/393 - (40%)	Gaps:	80/393 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly     9 QEKPPIVLDIGTAYTKLGFAAEAYPRKIMPTEVVM-----------------------TTTGIRK 50
            |:...||:|.||.:||.|.|.|.:...::|::|.|                       ...|:
  Rat   867 QKMAAIVIDTGTGFTKCGLAQENHVLSVVPSQVQMLQHPPQGQPQYVVPEHQEGSYSVLNRGV-- 929

  Fly    51 RLFDYDTPEELYDQLVDFLQTIFFKHLLVSPKERKFVLVENVFGSTVLRETLARVLFVHFDVSSV 115
             :.|:|..|.|:       |.:|:..|.|.|:|...::.::.......||.:|.:||..|.|.::
  Rat   930 -VSDWDALEVLW-------QHLFYCKLRVQPEEMAVLVADSPISPRTNREKVAEILFERFHVPAM 986

  Fly   116 LFVPVHLIALSTLAVPTALVVDVGYSETSVMPVFSG-VQIMAAFKDQSYGGSAIHAEIKRQLVES 179
            ..|...|:.|......|.|||..|:..:.|.|:.:| :..:..::....|...  .:...||:.|
  Rat   987 QTVHQALLTLYAYGRTTGLVVGSGHGTSYVAPIITGDLAPLDTYRLDVAGADL--TDYLAQLLMS 1049

  Fly   180 GVKESLLTESVLEDIKVRTCFV---TTMERAKARANGDENQPTPAPDVDYIVSDNDAVIQVPGLL 241
            | ..|.....::..||...|:|   ||.|.|:   |..:.|      ||:::.|...:  ..|..
  Rat  1050 G-GHSPPKGGIVRQIKEACCYVAMDTTTEMAR---NQSQVQ------VDFVLPDKHVI--TLGSE 1102

  Fly   242 RESAYEIMFEAS----NERDSLPHLILRSILDCTLDVRRALVESVFLVGGGSMVQGLLARLRQEL 302
            |....|.:|:.:    |:. .||.|.|.||....:..:..|:.:|.|.||.:::.|...|:||||
  Rat  1103 RFCCPEALFQPNLLGLNQL-GLPQLALLSISRLEVKQQEQLLANVVLEGGSTLINGFPERMRQEL 1166

  Fly   303 QHLLTEDPFYAERFHGELQFKFFNAVGKQN--FTAWLGGALCGATDLIQTRSLVKETYLKSEHVP 365
            ....|                   .:|..:  ..|||||::....|..|:..|.:..|   |...
  Rat  1167 GPGAT-------------------VLGSPHRAVAAWLGGSIMACRDSFQSLWLSRREY---EEEG 1209

  Fly   366 DWS 368
            .|:
  Rat  1210 PWA 1212

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Arp10	NP_001285452.1	ACTIN	11..340	CDD:214592	89/361 (25%)
Arp10	NP_001285452.1	NBD_sugar-kinase_HSP70_actin	12..367	CDD:302596	95/387 (25%)
Actl11	NP_001019959.2	PHA03247	<200..485	CDD:223021
Actl11	NP_001019959.2	NBD_sugar-kinase_HSP70_actin	871..1215	CDD:418402	96/389 (25%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5277
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D964605at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.910