DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Arp10 and Actl7a

DIOPT Version :9

Sequence 1:	NP_001285452.1	Gene:	Arp10 / 32969	FlyBaseID:	FBgn0031050	Length:	378	Species:	Drosophila melanogaster
Sequence 2:	NP_001011973.1	Gene:	Actl7a / 298017	RGDID:	1304697	Length:	440	Species:	Rattus norvegicus

Alignment Length:	416	Identity:	90/416 - (21%)
Similarity:	169/416 - (40%)	Gaps:	94/416 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 PIYESVMQEKP------PIVLDIGTAYTKLGFAAEAYPRKIMPTEVVMTTTG------------- 47
            |:..:|.:::|      .:|:|:||.:.|.|||  ..|:   ||..:.||.|
  Rat    59 PVKSAVSKDRPRLEVTKAVVVDLGTGFCKCGFA--GLPK---PTHKISTTVGKPYMETAKTGDNR 118

  Fly    48 ----IRKRLFDYDTPEEL-----------YDQLVDFLQTIFFKHLLVSPKERKFVLVENVFGSTV 97
                :.:.||:.|...:|           :|.:.|..:.:|.:.:.::|:|...::.:.......
  Rat   119 KETFVGRELFNPDIHLKLVNPLRHGIIVDWDTVQDIWEYLFRQEMKIAPEEHAVLVSDPPLSPHT 183

  Fly    98 LRETLARVLFVHFDVSSVLFVPVHLIALSTLAV-----PTALVVDVGYSETSVMPVFSGVQIMAA 157
            .||..|.:||..|:..:     :|:...|.|::     .:.|||:||:..:.|:|::.|..:.:.
  Rat   184 NREKYAEMLFETFNTPA-----MHIAYQSRLSMYSYGRTSGLVVEVGHGVSYVVPIYEGYPLPSI 243

  Fly   158 FKDQSYGGSAIHAEIKRQLVESGVKESLLTESVLEDIKVRTCFVT--TMERAKARANGDENQPTP 220
            .....|.||.:...:...:...|...|....|::||||.:.|||.  .:|..|.        |..
  Rat   244 TGRLDYAGSDLTNYLMNLMNNCGKHFSEDHLSIVEDIKTKCCFVALDPIEEKKI--------PPS 300

  Fly   221 APDVDYIVSDNDAVIQVPGLLRESAYEIMFEASNERDSLPHLI-----------LRSILDCTLDV 274
            ..::.|.:.|...:..  |..|....|:.|:        |.||           :..:..|.:.:
  Rat   301 EHEIHYTLPDGKEIRL--GQERFLCSEMFFK--------PSLIKSMQLGLHTQTVSCLNKCDIAL 355

  Fly   275 RRALVESVFLVGGGSMVQGLLARLRQELQHLLTEDPFYAERFHGELQFKFFNAVGKQNFTAWLGG 339
            :|.|:.::.|.||.:|::|...||::||..:...|.            ...|.:.:::...|.||
  Rat   356 KRDLMGNILLCGGSTMLRGFPNRLQKELSSMCPNDT------------PQVNVLPERDTAVWTGG 408

  Fly   340 ALCGATDLIQTRSLVKETYLKSEHVP 365
            ::..:....|...:.:..|  .||.|
  Rat   409 SILASLQGFQPLWVHRLEY--EEHGP 432

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Arp10	NP_001285452.1	ACTIN	11..340	CDD:214592	82/380 (22%)
Arp10	NP_001285452.1	NBD_sugar-kinase_HSP70_actin	12..367	CDD:302596	88/406 (22%)
Actl7a	NP_001011973.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..27
		ACTL7A_N	6..70	CDD:293445	2/10 (20%)
		Required for interaction with TES. /evidence=ECO:0000250	36..56
		NBD_sugar-kinase_HSP70_actin	72..440	CDD:302596	87/403 (22%)
		ACTIN	74..440	CDD:214592	87/401 (22%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5277
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D964605at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.820