DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Arp10 and Actl7a

DIOPT Version :9

Sequence 1:	NP_001285452.1	Gene:	Arp10 / 32969	FlyBaseID:	FBgn0031050	Length:	378	Species:	Drosophila melanogaster
Sequence 2:	NP_033741.1	Gene:	Actl7a / 11470	MGIID:	1343051	Length:	440	Species:	Mus musculus

Alignment Length:	423	Identity:	92/423 - (21%)
Similarity:	169/423 - (39%)	Gaps:	108/423 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 PIYESVMQEKP------PIVLDIGTAYTKLGFAAEAYPRKIMPTEVVMTTTG-----------IR 49
            |:..::.:::|      .:|:|:||.:.|.|||  ..|:   ||..:.||.|           .|
Mouse    59 PVKSTMSKDRPRLEVTKAVVVDLGTGFCKCGFA--GLPK---PTHKISTTVGKPYMETAKTGDNR 118

  Fly    50 KRLF------------------------DYDTPEELYDQLVDFLQTIFFKHLLVSPKERKFVLVE 90
            |..|                        |:||.:::::.|       |.:.:.::|:|...::.:
Mouse   119 KETFVGHELFNPDIHLKLVNPLRHGIIVDWDTVQDIWEYL-------FRQEMKIAPEEHAVLVSD 176

  Fly    91 NVFGSTVLRETLARVLFVHFDVSSVLFVPVHLIALSTLAV-----PTALVVDVGYSETSVMPVFS 150
            ........||..|.:||..|:..:     :|:...|.|::     .:.|||:||:..:.|:|::.
Mouse   177 PPLSPHTNREKYAEMLFETFNTPA-----MHIAYQSRLSMYSYGRTSGLVVEVGHGVSYVVPIYE 236

  Fly   151 GVQIMAAFKDQSYGGSAIHAEIKRQLVESGVKESLLTESVLEDIKVRTCFVT--TMERAKARANG 213
            |..:.:......|.||.:...:...:..||...|.....::||||.|.|||.  .:|..|.
Mouse   237 GYPLPSITGRLDYAGSDLTTYLMNLMNNSGKHFSEDHLGIVEDIKTRCCFVALDPIEEKKI---- 297

  Fly   214 DENQPTPAPDVDYIVSDNDAVIQVPGLLRESAYEIMFEASNERDSLPHLI-----------LRSI 267
                |.|..::.|.:.|...:..  |..|....|:.|:        |.||           :..:
Mouse   298 ----PAPEHEIHYTLPDGKEIRL--GQERFLCSEMFFK--------PSLIKSMQLGLHTQTVSCL 348

  Fly   268 LDCTLDVRRALVESVFLVGGGSMVQGLLARLRQELQHLLTEDPFYAERFHGELQFKFFNAVGKQN 332
            ..|.:.::|.|:.::.|.||.:|::|...||::||..:...|.            ...|.:.:::
Mouse   349 NKCDIALKRDLMGNILLCGGSTMLRGFPNRLQKELSSMCPNDT------------PQVNVLPERD 401

  Fly   333 FTAWLGGALCGATDLIQTRSLVKETYLKSEHVP 365
            ...|.||::..:....|...:.:..|  .||.|
Mouse   402 TAVWTGGSILASLQGFQPLWVHRLEY--EEHGP 432

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Arp10	NP_001285452.1	ACTIN	11..340	CDD:214592	85/387 (22%)
Arp10	NP_001285452.1	NBD_sugar-kinase_HSP70_actin	12..367	CDD:302596	91/413 (22%)
Actl7a	NP_033741.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..29
		ACTL7A_N	6..70	CDD:293445	1/10 (10%)
		Required for interaction with TES. /evidence=ECO:0000250	36..56
		NBD_sugar-kinase_HSP70_actin	72..440	CDD:302596	90/410 (22%)
		ACTIN	74..440	CDD:214592	90/408 (22%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5277
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810