DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Arp10 and ACTL7A

DIOPT Version :9

Sequence 1:	NP_001285452.1	Gene:	Arp10 / 32969	FlyBaseID:	FBgn0031050	Length:	378	Species:	Drosophila melanogaster
Sequence 2:	NP_006678.1	Gene:	ACTL7A / 10881	HGNCID:	161	Length:	435	Species:	Homo sapiens

Alignment Length:	425	Identity:	93/425 - (21%)
Similarity:	167/425 - (39%)	Gaps:	112/425 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 PIYESVMQEKP------PIVLDIGTAYTKLGFAAEAYPRKIMPTEVVMTTTG-----------IR 49
            |......:|:|      .:|:|:||.|.|.|||  ..||   ||..:.||.|           .|
Human    54 PTESKAAKERPKQEVTKAVVVDLGTGYCKCGFA--GLPR---PTHKISTTVGKPYMETAKTGDNR 113

  Fly    50 KRLF------------------------DYDTPEELYDQLVDFLQTIFFKHLLVSPKERKFVLVE 90
            |..|                        |:||.:::::.|       |.:.:.::|:|...::.:
Human   114 KETFVGQELNNTNVHLKLVNPLRHGIIVDWDTVQDIWEYL-------FRQEMKIAPEEHAVLVSD 171

  Fly    91 NVFGSTVLRETLARVLFVHFDVSSVLFVPVHLIALSTLAV-----PTALVVDVGYSETSVMPVFS 150
            ........||..|.:||..|:..:     :|:...|.|::     .:.|||:||:..:.|:|::.
Human   172 PPLSPHTNREKYAEMLFEAFNTPA-----MHIAYQSRLSMYSYGRTSGLVVEVGHGVSYVVPIYE 231

  Fly   151 GVQIMAAFKDQSYGGSAIHAEIKRQLVESGVKESLLTESVLEDIKVRTCFVT--TMERAKARANG 213
            |..:.:......|.||.:.|.:...|..:|.:.:.....::||||.:.|||.  .:|..|.
Human   232 GYPLPSITGRLDYAGSDLTAYLLGLLNSAGNEFTQDQMGIVEDIKKKCCFVALDPIEEKKV---- 292

  Fly   214 DENQPTPAPDVDYIVSDNDAVIQVPGLLRES--AYEIMFEASNERDSLPHLI-----------LR 265
                |.....:.|::.|...:    .|.:|.  ..|:.|:        |.||           :.
Human   293 ----PLSEHTIRYVLPDGKEI----QLCQERFLCSEMFFK--------PSLIKSMQLGLHTQTVS 341

  Fly   266 SILDCTLDVRRALVESVFLVGGGSMVQGLLARLRQELQHLLTEDPFYAERFHGELQFKFFNAVGK 330
            .:..|.:.::|.|:.::.|.||.:|:.|...||::||..:...|.            ...|.:.:
Human   342 CLNKCDIALKRDLMGNILLCGGSTMLSGFPNRLQKELSSMCPNDT------------PQVNVLPE 394

  Fly   331 QNFTAWLGGALCGATDLIQTRSLVKETYLKSEHVP 365
            ::...|.||::..:....|...:.:..|  .||.|
Human   395 RDSAVWTGGSILASLQGFQPLWVHRFEY--EEHGP 427

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Arp10	NP_001285452.1	ACTIN	11..340	CDD:214592	85/389 (22%)
Arp10	NP_001285452.1	NBD_sugar-kinase_HSP70_actin	12..367	CDD:302596	91/415 (22%)
ACTL7A	NP_006678.1	ACTL7A_N	1..65	CDD:293445	2/10 (20%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..64		2/9 (22%)
		Required for interaction with TES	31..51
		NBD_sugar-kinase_HSP70_actin	67..435	CDD:302596	90/412 (22%)
		ACTIN	69..435	CDD:214592	90/410 (22%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5277
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D964605at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.820