DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Arp10 and ACTL7B

DIOPT Version :9

Sequence 1:	NP_001285452.1	Gene:	Arp10 / 32969	FlyBaseID:	FBgn0031050	Length:	378	Species:	Drosophila melanogaster
Sequence 2:	NP_006677.1	Gene:	ACTL7B / 10880	HGNCID:	162	Length:	415	Species:	Homo sapiens

Alignment Length:	381	Identity:	80/381 - (20%)
Similarity:	153/381 - (40%)	Gaps:	65/381 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly    14 IVLDIGTAYTKLGFAAEAYPRKIMPTEVVMTTTGIR-----------------KRLFDYDTPEEL 61
            :::|:|:.|.|.|:|.|  ||   ||..:.:|.|.|                 ..|.:.:.|.:|
Human    52 VIIDLGSQYCKCGYAGE--PR---PTYFISSTVGKRCPEAADAGDTRKWTLVGHELLNTEAPLKL 111

  Fly    62 -----------YDQLVDFLQTIFFKHLLVSPKERKFVLVENVFGSTVLRETLARVLFVHFDVSSV 115
                       :|.:.|..:.||...:.:.|:|...::.:.....:..||..|.::|..|.:.::
Human   112 VNPLKHGIVVDWDCVQDIWEYIFRTAMKILPEEHAVLVSDPPLSPSSNREKYAELMFETFGIPAM 176

  Fly   116 LFVPVHLIALSTLAVPTALVVDVGYSETSVMPVFSGVQIMAAFKDQSYGGSAIHAEIKRQLVESG 180
            ......|:::.:....:.|||:.|:..:.|:|:..|..:........|.|..:...:.:.|.|:|
Human   177 HVTSQSLLSIYSYGKTSGLVVESGHGVSHVVPISEGDVLPGLTSRADYAGGDLTNYLMQLLNEAG 241

  Fly   181 VKESLLTES---VLEDIKVRTCFVTTMERAKARANGDENQPTPAPDVDYIVSDNDAVIQVPGLLR 242
               ...|:.   ::|.||.:.|:...:...:.....:|.:      |||.:.|...:  ..|..|
Human   242 ---HAFTDDHLHIIEHIKKKCCYAAFLPEEELGLVPEELR------VDYELPDGKLI--TIGQER 295

  Fly   243 ESAYEIMFE---ASNERDSLPHLILRSILDC-TLDVRRALVESVFLVGGGSMVQGLLARLRQELQ 303
            ....|::|:   |.:.:..||.|....:..| ....:..:..:|.|.||.:|:.|...|.::||.
Human   296 FRCSEMLFQPSLAGSTQPGLPELTAACLGRCQDTGFKEEMAANVLLCGGCTMLDGFPERFQRELS 360

  Fly   304 HLLTED-PFYAERFHGELQFKFFNAVGKQNFTAWLGGALCGATDLIQTRSLVKETY 358
            .|...| |..|             |..::..:.|.||::..:....|...:.||.:
Human   361 LLCPGDSPAVA-------------AAPERKTSVWTGGSILASLQAFQQLWVSKEEF 403

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Arp10	NP_001285452.1	ACTIN	11..340	CDD:214592	76/361 (21%)
Arp10	NP_001285452.1	NBD_sugar-kinase_HSP70_actin	12..367	CDD:302596	80/381 (21%)
ACTL7B	NP_006677.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..31
ACTL7B	NP_006677.1	NBD_sugar-kinase_HSP70_actin	51..415	CDD:327376	80/381 (21%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5277
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D964605at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.910