DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment e(y)3 and DPF3

DIOPT Version :9

Sequence 1:	NP_001259719.1	Gene:	e(y)3 / 32965	FlyBaseID:	FBgn0087008	Length:	2012	Species:	Drosophila melanogaster
Sequence 2:	NP_001267473.1	Gene:	DPF3 / 8110	HGNCID:	17427	Length:	412	Species:	Homo sapiens

Alignment Length:	453	Identity:	97/453 - (21%)
Similarity:	158/453 - (34%)	Gaps:	113/453 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly   577 PSPG---SSPTHVPNNFTGRISPKGLLIDCL-RMQTAIGCYVPEEADSRVRPAASPNSNILLSQL 637
            |:|.   |.|....|:.||.:.|..|.::.| .|.|.:|....:||....|   |.||. |.::.
Human    30 PNPQLIFSFPISSRNHITGLMPPGKLKLENLFHMCTRLGDQFYKEAIEHCR---SYNSR-LCAER 90

  Fly   638 TAPAKSFTTTTPKSKSSKYPQLTERLMANGSGTGGGSVIAAESEAVVGPL-PAANPAQSIIE--- 698
            :.......:.|..::::.|..:.:|....|...|......|........| |..:|...::|
Human    91 SVRLPFLDSQTGVAQNNCYIWMEKRHRGPGLAPGQLYTYPARCWRKKRRLHPPEDPKLRLLEIKP 155

  Fly   699 SIEILDTPDGSPRVAYMDEDSNPMLNKHLQTIHKLAMDHGVEQRMDTQDNNNENHLKR------T 757
            .:|:....||     :..|.:         |:..|....|||:::|.::..:...::|      .
Human   156 EVELPLKKDG-----FTSEST---------TLEALLRGEGVEKKVDAREEESIQEIQRVLENDEN 206

  Fly   758 NSEGNESP--SSRLPPSKQRRLDNDENDQQTQNCHDPARKCSESLQALPPSHRSRKQKHERILNT 820
            ..||||..  ...:|..|.|...........:..||.|                .::.|::....
Human   207 VEEGNEEEDLEEDIPKRKNRTRGRARGSAGGRRRHDAA----------------SQEDHDKPYVC 255

  Fly   821 DLEGSLFPPTQQQSISTPDQNGALSSEVEGEDAKAQDPLEPATPQPPPVATPAGTGKKRGRPKRI 885
            |:.|..:  ..:..:|....:..|:|| ||::|:.|:     |..||           ..|.:..
Human   256 DICGKRY--KNRPGLSYHYAHTHLASE-EGDEAQDQE-----TRSPP-----------NHRNENH 301

  Fly   886 QNQSSPD-------------GGGAVTPKPGTPQEEANSAVKSRRVQLLRKRLAIDMVSVGQEQAD 937
            :.|..||             ||..:..|.|.|:|..:.|...|...|            |.|
Human   302 RPQKGPDGTVIPNNYCDFCLGGSNMNKKSGRPEELVSCADCGRSAHL------------GGE--- 351

  Fly   938 MKAKEKESSVGVPNAR-VEDGLAETLESPKTRDHRPLRATRRTTTSTNTNLQPTPKSTRKRQS 999
             ..||||::..   || .||....|.||..:..|           ..:.:....|:|.|.|:|
Human   352 -GRKEKEAAAA---ARTTEDLFGSTSESDTSTFH-----------GFDEDDLEEPRSCRGRRS 399

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
e(y)3	NP_001259719.1	PHD_SF	1700..1754	CDD:304600
		RanBP2-type Zn finger	1700..1725	CDD:275375
		RanBP2-type Zn finger	1749..1775	CDD:275375
		PHD2_PHF10	1756..1799	CDD:277004
DPF3	NP_001267473.1	Requiem_N	68..139	CDD:290758	14/74 (19%)
DPF3	NP_001267473.1	PHD_SF	316..>347	CDD:304600	8/30 (27%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D312433at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR10615
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	3.020