Protein Alignment e(y)3 and Phf10

DIOPT Version :10

• Sequence 1: NP_001259719.1
• Gene: e(y)3 / 32965
• FlyBaseID: FBgn0087008
• Length: 2012
• Species: Drosophila melanogaster
• Sequence 2: NP_077212.3
• Gene: Phf10 / 72057
• MGIID: 1919307
• Length: 497
• Species: Mus musculus
• Alignment Length: 536
• Identity: 155/536 - (28%)
• Similarity: 243/536 - (45%)
• Gaps: 103/536 - (19%)

  Fly  1284 SMMDSNQGQSADAILGSALKRP-KKKKM------ETCVAEDTD-----YSASSIAEYDWPPPKGC 1336
            |..|.|:..|.|.      ..| |:::|      .:|.....|     |.|.::.||.||
Mouse    26 SPKDDNEDNSNDG------THPCKRRRMGSGDSSRSCETSSQDLSFSYYPAENLIEYKWP----- 79

  Fly  1337 CPSKNRDTFMIQEQVALYLGITSFKRKYPDLPRRSVDMEERNWLQEKGLVSEKLCDLGITAVWAS 1401
             |.:..:.:|:||||:.|||:||||||||||.||.:..:|:.:|:|..:::|..|.||:||:.:.
Mouse    80 -PDETGEYYMLQEQVSEYLGVTSFKRKYPDLERRDLSHKEKLYLRELNVITETQCTLGLTALRSD 143

  Fly  1402 DILDIMYADFFDKYEEYKEYIRRK-------HLREIEAKQKALGLTVGAGRGLQARDRAMLSATK 1459
            :::|:|..::..|:.||...::.|       |.:|....|:.....|.|.:..:...:|...|.:
Mouse   144 EVIDLMIKEYPAKHAEYSVILQEKERQRITDHYKEYSQMQQQSTQKVEASKVPEYIKKAAKKAAE 208

  Fly  1460 WNAYFNKSRKDERQSCMDLQTFTINQPQPRTAPTCTRLERSTSDLIRAVAEEANIPAPPNLLPPR 1524
            :|:..|:.|.:||::..||||..|..||.:.                            .:||
Mouse   209 FNSNLNRERMEERRAYFDLQTHVIQVPQGKY----------------------------KVLP-- 243

  Fly  1525 DYDEAFRNSDYAYPLTVVPDQFSMAYRQFEPAELRAYPLDTALDKPPTDLMAQLLQAKSEAVGSD 1589
                ..|....:||:.::|.||...|:::.|.|||..||:|||.:||.|       .:..|:.||
Mouse   244 ----TDRTKVSSYPVALIPGQFQEYYKRYSPDELRYLPLNTALYEPPLD-------PELPALDSD 297

  Fly  1590 EIKTSAPAPKDLGQEQSAIKSVTVTAPVRRSRRSTRQQTDKVRTASSSSTSSAQSVSSASSGNGS 1654
                   ...|.|::...                     |:.|....:|.||:.:||...|...|
Mouse   298 -------GDSDDGEDGGG---------------------DEKRKNKGTSDSSSGNVSEGDSPPDS 334

  Fly  1655 SSDTESGDESDFSSTSSCSSSTGASSGAGSEDEDGNECSSSVRLSTCGVCLRSQHRNARDMPEAF 1719
            ..||..|.:.. ....:.....|:.....|:...|.: ...:..:.||:||:.:..|.:...|:.
Mouse   335 QEDTFHGRQKS-KDKMATPRKDGSKRSVLSKSAPGYK-PKVIPNALCGICLKGKESNKKGKAESL 397

  Fly  1720 IRCYTCRKRVHPSCVDMPPRMVGRVRNYNWQCAGCKCCIKCRSSQRPGKMLYCEQCDRGYHIYCL 1784
            |.|..|....||||:||...:|..::.|.|||..||.||.|.......:|::|:.||||||.:|:
Mouse   398 IHCSQCDNSGHPSCLDMTMELVSMIKTYPWQCMECKTCIICGQPHHEEEMMFCDVCDRGYHTFCV 462

  Fly  1785 GLRTVPDGRWSCERCC 1800
            ||..:|.|||.|: ||
Mouse   463 GLGAIPSGRWICD-CC 477

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
e(y)3	NP_001259719.1	WH_NTD_PHF10	1325..1418	CDD:411035	37/92 (40%)
		PHD_SF	1700..1754	CDD:473978	20/53 (38%)
		RanBP2-type Zn finger	1700..1725	CDD:275375	8/24 (33%)
		RanBP2-type Zn finger	1749..1775	CDD:275375	10/25 (40%)
		PHD2_PHF10	1756..1799	CDD:277004	19/42 (45%)
Phf10	NP_077212.3	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..61		9/40 (23%)
		WH_NTD_PHF10	72..160	CDD:411035	37/93 (40%)
		SAY	88..294		75/246 (30%)
		Essential to induce neural progenitor proliferation	88..184		37/95 (39%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	284..368		22/119 (18%)
		Essential to induce neural progenitor proliferation	291..333		13/69 (19%)
		PHD1_PHF10	379..432	CDD:277003	20/52 (38%)
		PHD2_PHF10	434..477	CDD:277004	19/43 (44%)