DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment e(y)3 and DPF2

DIOPT Version :9

Sequence 1:	NP_001259719.1	Gene:	e(y)3 / 32965	FlyBaseID:	FBgn0087008	Length:	2012	Species:	Drosophila melanogaster
Sequence 2:	XP_024304405.1	Gene:	DPF2 / 5977	HGNCID:	9964	Length:	575	Species:	Homo sapiens

Alignment Length:	613	Identity:	134/613 - (21%)
Similarity:	209/613 - (34%)	Gaps:	171/613 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly  1218 HQPDPERLK--GLFSPSPQVFEEDTRMSADLSNSNQSMASLMEPPLTPQKQPDFLNNEESQSSM- 1279
            |.|:..||.  .:...:.|..:::..:|.|.|:..   |.|...||..:..||...:::|....
Human    86 HPPEDPRLSFPSIKPDTDQTLKKEGLISQDGSSLE---ALLRTDPLEKRGAPDPRVDDDSLGEFP 147

  Fly  1280 VSNVSMMDSNQGQSADAILGSALKRPKKKKME----TCVAEDTDYSASSIAEYDWPPPKGCCPSK 1340
            |:|                    .|.:|:.:|    ....:|.||      |.|.|..:|...||
Human   148 VTN--------------------SRARKRILEPDDFLDDLDDEDY------EEDTPKRRGKGKSK 186

  Fly  1341 NRDTFMIQEQVALYLGITSFKRKYPDLPRRSVD---MEERNWLQEKGLVSEKLCDLGITAVWASD 1402
            .:             |:.|.::|        :|   :|:|    :|....:..|   :|:.|...
Human   187 GK-------------GVGSARKK--------LDASILEDR----DKPYACDSEC---LTSGWVDL 223

  Fly  1403 ILDIMYADFFDKYEEYKEYIRRKHLREIEAKQKALGLTVGAGRGLQARDRAMLSATKWNAYFNKS 1467
            .||                       ...|.....|..|...|.|:.....:|.|
Human   224 ALD-----------------------PAPALDMRGGRVVFLPRVLKQTWALVLPA---------- 255

  Fly  1468 RKDERQSCMDLQTFTINQPQPRTAPTCTRLER------------STSDLIRAVAEEANIPAPPNL 1520
                  .|..|:......|...|..||...||            :|:..:....:...:..|...
Human   256 ------DCFRLRPLGGLGPCYMTGGTCMLWERFLPSSGVGLLVGATAGRVGLSTDGLQVSWPQLS 314

  Fly  1521 LPPRDYDEAFRNSDYAYPLTVVPDQFSMAYRQFEPAELRAYPLDTALDKPPTDLMAQLL--QAKS 1583
            ..||....:|..|...:.|:.:|        .|.|:.|.|        ..|...:::||  .|.:
Human   315 QGPRGLTLSFSTSVLFFFLSALP--------HFCPSTLGA--------PSPLGFLSRLLCFPAAA 363

  Fly  1584 EAVGSDEIKTSAPAPKDLG--QEQSAIKSVTVTAPVRRSRRSTRQQTDKVRTASSSSTSSAQSVS 1646
            ..|.|    .|.|:..|..  ...|..:..|..||.|...:       :.:.....|...|.|
Human   364 APVSS----VSRPSSHDFSFCLSDSFKQKHTSKAPQRVCGK-------RYKNRPGLSYHYAHS-- 415

  Fly  1647 SASSGNGSSSDTESGDESDFSSTSSCSSSTGASSGAGSEDEDGNECSSSVRL--STCGVCLRSQH 1709
                   ..::.|..|:.|....:..|..        ||::...:....:.|  :.|..||....
Human   416 -------HLAEEEGEDKEDSQPPTPVSQR--------SEEQKSKKGPDGLALPNNYCDFCLGDSK 465

  Fly  1710 RNAR-DMPEAFIRCYTCRKRVHPSCVDMPPRMVGRVRNYNWQCAGCKCCIKCRSSQRPGKMLYCE 1773
            .|.: ..||..:.|..|.:..||||:...|.|:..|:.|.|||..||||..|.:|:...::|:|:
Human   466 INKKTGQPEELVSCSDCGRSGHPSCLQFTPVMMAAVKTYRWQCIECKCCNICGTSENDDQLLFCD 530

  Fly  1774 QCDRGYHIYCL--GLRTVPDGRWSCERC 1799
            .||||||:|||  .:...|:|.|||..|
Human   531 DCDRGYHMYCLTPSMSEPPEGSWSCHLC 558

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
e(y)3	NP_001259719.1	PHD_SF	1700..1754	CDD:304600	19/54 (35%)
		RanBP2-type Zn finger	1700..1725	CDD:275375	7/25 (28%)
		RanBP2-type Zn finger	1749..1775	CDD:275375	11/25 (44%)
		PHD2_PHF10	1756..1799	CDD:277004	20/44 (45%)
DPF2	XP_024304405.1	Requiem_N	13..79	CDD:316564
		SFP1	<397..417	CDD:227516	3/35 (9%)
		PHD1_DPF2_like	456..511	CDD:277161	19/54 (35%)
		PHD2_d4	513..558	CDD:277005	20/44 (45%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D312433at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR10615
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	2.110