DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment e(y)3 and PHF10

DIOPT Version :9

Sequence 1:	NP_001259719.1	Gene:	e(y)3 / 32965	FlyBaseID:	FBgn0087008	Length:	2012	Species:	Drosophila melanogaster
Sequence 2:	NP_060758.2	Gene:	PHF10 / 55274	HGNCID:	18250	Length:	498	Species:	Homo sapiens

Alignment Length:	559	Identity:	158/559 - (28%)
Similarity:	248/559 - (44%)	Gaps:	118/559 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly  1260 PLTPQKQPDFLNNEESQSSMVSNVSMMDSNQGQSADAILGSALKRPKKKKM------ETCVAEDT 1318
            |.||..|                 |..|.|:..|.|....|     |:::|      .:|.....
Human    20 PATPGAQ-----------------SPKDDNEDNSNDGTQPS-----KRRRMGSGDSSRSCETSSQ 62

  Fly  1319 D-----YSASSIAEYDWPPPKGCCPSKNRDTFMIQEQVALYLGITSFKRKYPDLPRRSVDMEERN 1378
            |     |.|.::.||.||      |.:..:.:|:||||:.|||:||||||||||.||.:..:|:.
Human    63 DLGFSYYPAENLIEYKWP------PDETGEYYMLQEQVSEYLGVTSFKRKYPDLERRDLSHKEKL 121

  Fly  1379 WLQEKGLVSEKLCDLGITAVWASDILDIMYADFFDKYEEYKEYIRRK-------HLREIEAKQKA 1436
            :|:|..:::|..|.||:||:.:.:::|:|..::..|:.||...::.|       |.:|....|:.
Human   122 YLRELNVITETQCTLGLTALRSDEVIDLMIKEYPAKHAEYSVILQEKERQRITDHYKEYSQMQQQ 186

  Fly  1437 LGLTVGAGRGLQARDRAMLSATKWNAYFNKSRKDERQSCMDLQTFTINQPQPRTAPTCTRLERST 1501
            ....|.|.:..:...:|...|.::|:..|:.|.:||::..||||..|..||.:.
Human   187 NTQKVEASKVPEYIKKAAKKAAEFNSNLNRERMEERRAYFDLQTHVIQVPQGKY----------- 240

  Fly  1502 SDLIRAVAEEANIPAPPNLLPPRDYDEAFRNSDYAYPLTVVPDQFSMAYRQFEPAELRAYPLDTA 1566
                             .:||..      |....:||:.::|.||...|:::.|.|||..||:||
Human   241 -----------------KVLPTE------RTKVSSYPVALIPGQFQEYYKRYSPDELRYLPLNTA 282

  Fly  1567 LDKPPTDLMAQLLQAKSEAVGSDEIKTSAPAPKDLGQEQSAIKSVTVTAPVRRSRRSTRQQTDKV 1631
            |.:||.|       .:..|:.||       ...|.|::                     .:.|:.
Human   283 LYEPPLD-------PELPALDSD-------GDSDDGED---------------------GRGDEK 312

  Fly  1632 RTASSSSTSSAQSVSSASSGNGSSSDTESGDESDFSSTSSCSSSTGASSGAGSEDEDGNECSSSV 1696
            |....:|.||:.:||...|...|..|:..|.:.. ...::.....|......|:...|.: ...:
Human   313 RKNKGTSDSSSGNVSEGESPPDSQEDSFQGRQKS-KDKAATPRKDGPKRSVLSKSVPGYK-PKVI 375

  Fly  1697 RLSTCGVCLRSQHRNARDMPEAFIRCYTCRKRVHPSCVDMPPRMVGRVRNYNWQCAGCKCCIKCR 1761
            ..:.||:||:.:..|.:...|:.|.|..|....||||:||...:|..::.|.|||..||.||.|.
Human   376 PNAICGICLKGKESNKKGKAESLIHCSQCENSGHPSCLDMTMELVSMIKTYPWQCMECKTCIICG 440

  Fly  1762 SSQRPGKMLYCEQCDRGYHIYCLGLRTVPDGRWSCERCC 1800
            ......:|::|:.||||||.:|:||..:|.|||.|: ||
Human   441 QPHHEEEMMFCDMCDRGYHTFCVGLGAIPSGRWICD-CC 478

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
e(y)3	NP_001259719.1	PHD_SF	1700..1754	CDD:304600	20/53 (38%)
		RanBP2-type Zn finger	1700..1725	CDD:275375	8/24 (33%)
		RanBP2-type Zn finger	1749..1775	CDD:275375	10/25 (40%)
		PHD2_PHF10	1756..1799	CDD:277004	19/42 (45%)
PHF10	NP_060758.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..62		13/63 (21%)
		SAY	89..295		75/246 (30%)
		Essential to induce neural progenitor proliferation. /evidence=ECO:0000250	89..185		37/95 (39%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	285..368		21/118 (18%)
		Essential to induce neural progenitor proliferation. /evidence=ECO:0000250	292..334		13/69 (19%)
		PHD1_PHF10	379..433	CDD:277003	20/53 (38%)
		PHD2_PHF10	435..478	CDD:277004	19/43 (44%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165143279
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1512
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D312433at33208
OrthoFinder	1	1.000	-	-		FOG0007125
OrthoInspector	1	1.000	-	-		oto89274
orthoMCL	1	0.900	-	-		OOG6_107234
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R6219
SonicParanoid	1	1.000	-	-		X5215
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	10	9.640