Protein Alignment e(y)3 and Kat6b

DIOPT Version :9

• Sequence 1: NP_001259719.1
• Gene: e(y)3 / 32965
• FlyBaseID: FBgn0087008
• Length: 2012
• Species: Drosophila melanogaster
• Sequence 2: XP_006519326.1
• Gene: Kat6b / 54169
• MGIID: 1858746
• Length: 2054
• Species: Mus musculus
• Alignment Length: 2189
• Identity: 386/2189 - (17%)
• Similarity: 659/2189 - (30%)
• Gaps: 768/2189 - (35%)

  Fly     6 QQQMVAATSSSGSES--------GTAVESAAATSTAGSAGAAGR-PQSNCSANSNAKSVAASSTS 61
            :|::::.||..||.|        |...::..:|:.:....|:|: ..|..:.....:..|.:.|:
Mouse   351 KQRLLSVTSDEGSMSAFTGRGSPGRGQKTKVSTTPSSGHAASGKHSSSRLAVTDPTRPGATTKTT 415

  Fly    62 EEEQRVS-STSSPAQRDQQLNADRDREQEPEPQQQQQREEALQ-HQHNQP-----------GHI- 112
            .....:| ||....::.:.|.....:...|.|..::.|.|.:. .:|.:|           .|:
Mouse   416 TSSTYISASTLKVNKKTKGLIDGLTKFFTPSPDGRRSRGEIIDFSKHYRPRKKVSQKQSCTSHVL 480

  Fly   113 -TSTTAS---PPPTLPPPTTPCDDAPSTTGASASASSASGEAPSAASAAGAAGGPMAATALEVES 173
             |.||..   .|..|.||......:||:..:|:|.||.|.::.|:.|      |..:.::|...|
Mouse   481 ATGTTQKLKPAPSALLPPAPISGQSPSSQKSSSSTSSTSTQSSSSQS------GEPSFSSLTNNS 539

  Fly   174 EER---DGHKIILKLSKHANPNSNANESQPGGDERRVEPLRIQLPCGGAEGGLVAKQQDAFDADA 235
            :.:   ||...|.         :...:|:..|......|.|::..   .|....||.:..|....
Mouse   540 QLKALFDGLSHIY---------TTQGQSRKKGHPSYAPPKRMRRK---TEFSSTAKAKARFFGKR 592

  Fly   236 SSCS-----SSCAEDEVATTLGQQLRNTPHIVPKLTIRAANERRVGSVVPKLTIKLPENPAASGS 295
            ...|     |||:   ...|.|...:...|.  |.|......|.:|.:..|:|
Mouse   593 DFRSRLLSHSSCS---WGMTRGHIFKAIAHF--KRTTFLKKHRMLGRLKYKVT------------ 640

  Fly   296 NSNSGSCSAAVSGAQSAMPAKNDAHLSSLSPASASSSSASSSSSSSSSSSLAEMQTVPKLMIK-- 358
                                          |...:.||...|.:....:...:..|..|:.||
Mouse   641 ------------------------------PQMGTPSSGKGSLADGRINPDQDNDTDIKISIKQE 675

  Fly   359 ---TTLAGSSCISSSEELP--QQQQQI--PKLTIKTGGGGQEHVHTVIMTHDLNNAQSIPKLTIK 416
               .:|.|:..:.:.|:|.  :|.|::  .|:..::|            ..|.....|:    |:
Mouse   676 SADVSLVGNKELVTEEDLDVFKQAQELSWEKIECESG------------VEDCGRYPSV----IE 724

  Fly   417 TKSIEMIEDEQAAKLEQQLQPLPKLTIKNLCSPKHKVRAVLEEKPPTAASKLAIPKPTPNPTPAP 481
            ....| |:...::...|:...||||.:...|....|.:.:|
Mouse   725 FGKYE-IQTWYSSPYPQEYARLPKLYLCEFCLKYMKSKNIL------------------------ 764

  Fly   482 MTNGGESNSSSQEFCGFSDPDADIAAPASDDVRRNSDDMV-IDDSLSK--------------EH- 530
                    ....:.||:..|      ||::..||....:. :|.::||              :|
Mouse   765 --------LRHSKKCGWFHP------PANEIYRRKDLSVFEVDGNMSKIYCQNLCLLAKLFLDHK 815

  Fly   531 ------DPKIFHNLPPMPASNGIASGGSKASKASKS--AQSQHNV------------------VD 569
                  :|.:|:.|     :.....|.......||.  .|.::||                  :|
Mouse   816 TLYYDVEPFLFYVL-----TKNDEKGCHLVGYFSKEKLCQQKYNVSCIMIMPQHQRQGFGRFLID 875

  Fly   570 MVDLTSSPSPGSSPTHVPNNFTGRISP----KGLLIDCLRMQTAIGCYVPEEADSRVRPAASPNS 630
            ...|.|.....:.....|.:..||:|.    |.::::.|        |...|....::
Mouse   876 FSYLLSRREGQAGSPEKPLSDLGRLSYLAYWKSVILEYL--------YRHHERHISIK------- 925

  Fly   631 NILLSQLTAPAKSFTTTTPKSKSSKYPQLTERLMANGSGTGGGSVIAAESEAVVGPLPAANPAQS 695
              .:|:.|........||     .::..:.:|       ..|..||....:.::|.:
Mouse   926 --AISRATGMCPHDIATT-----LQHLHMIDR-------RDGRFVIIRREKLILGHM-------- 968

  Fly   696 IIESIEILDTPDGSPRVAYMDEDS---NPMLNKHLQTIHKLAMDHGVEQRMDTQDNNNENHLKRT 757
              |.::....|:      .:|.:|   .|||           :.:.|....:.:.......|...
Mouse   969 --EKLKNCSRPN------ELDPESLRWTPML-----------ISNAVVSEEEREAEKEAERLMEQ 1014

  Fly   758 NS----EGNESPSSRLPPSKQRRLDNDENDQQTQNCHDPARK--CSESLQALPPSHRSRKQKHER 816
            .|    |..|..|||:    ..|..:.:...:.:..|.|.|:  ..|..|.|..|..|.:::.|
Mouse  1015 ASCWEKEEQEILSSRV----SSRQSSAKVQSKNKYLHSPERRPVAGERGQLLELSKESSEEEEE- 1074

  Fly   817 ILNTDLEGSLFPPTQQQSISTPDQNGALSSEVEGEDAKAQDPLEPATPQPPPVATPAGTGKKRGR 881
                                        ..|.:.|:.:.::..|.....||.:..|.....||.|
Mouse  1075 ----------------------------EEEEDDEEEEEEEEEESIQTSPPRLTKPQSVSIKRKR 1111

  Fly   882 PKRIQNQSSPDGGGAVTPKPGTPQEEANSAVKSRRVQLLRKRLAIDMVSVGQEQADMKAKEK--- 943
            |            ..|..|.|..:...||:|.:..:.        :...|..|..|...:|:
Mouse  1112 P------------FVVKKKRGRKRRRINSSVTTETIS--------ETTEVLNEPFDNSDEERPMP 1156

  Fly   944 --ESSVGVPNARVEDGLAETLESPKTRDHRPLRATRRTTTSTNTNLQPTPKSTRKRQSKASVQQS 1006
              |.:..:|   ||:|..:.: ..|...|:|                     .:|||::
Mouse  1157 QLEPTCEIP---VEEGGRKPV-LRKAFPHQP---------------------GKKRQTE------ 1190

  Fly  1007 QLPPPTMAQFGSSESESNNNNNSSISFALSAQIDLTMCSSSSSTSSGAAANQQVI--------GG 1063
                         |.|..:|:....:......:|    ..:.....|:..|.:.:        |.
Mouse  1191 -------------EEEGEDNHFFKTAALCRKDVD----DDAEHLKEGSKDNPEPLKCRQVWPKGA 1238

  Fly  1064 SGSSSMLPPTTILSSSDPL-----PDVIFQPNDFSSIMATQQLRSSRPSSISCGSTGGSQPDCHD 1123
            ....|....:....:...|     |:...:|.|..:|...::|...:      ||..|.:.:.
Mouse  1239 KRGLSKWKQSKERKTGFKLNLYTPPETPMEPEDQVTIEEQKELSEDK------GSPVGMEREV-- 1295

  Fly  1124 EDNYTSALDNSGVNSSSSDETALPMPPTRGRGRGRRSRGGRGRGSSSVDRAVSVGGTASTTPATQ 1188
            .:...:.|...|   |..:||.:|:.|       .:|.||:      ||....:.|...
Mouse  1296 TETVDALLPQEG---SRREETGIPVSP-------HKSPGGK------VDEEDLIRGEEE------ 1338

  Fly  1189 PRAPRMSRGASAVAKAIAMSRPRCVGGLKHQPDPERLKGLFSPSPQVFEEDTRMSADLSNSNQSM 1253
                                     |..:.:.:.||       ..|..||:.....||..:...
Mouse  1339 -------------------------GEEEGEEEGER-------EEQEEEEEVTTEKDLDGAKSK- 1370

  Fly  1254 ASLMEPPLTPQKQ-PDFLNNEESQSSMVSNVSMMDSNQGQSADAILGSALKRPKKKKMETCVAED 1317
             ...||.::.:|: |..|.:.|.........|   .|:...||.                  .:|
Mouse  1371 -ENPEPEISMEKEDPVHLGDHEEDEDEEEEPS---HNEDHDADD------------------EDD 1413

  Fly  1318 TDYSASSIAEYDWPPPKGCCPSKNRDTF---MIQEQVALYLGITSFKRKYPDLPRRSVDM----- 1374
            ....|:::...|.|          |:||   :..::..|.|.|.........|....||:
Mouse  1414 GHMEAANMERGDLP----------RETFKDALEGQEAFLDLSIQPSHSNPEVLMNCGVDLTMSCN 1468

  Fly  1375 -EERNWLQEKGLVSEKLCDLGITAVWASDILDIMYADFFDKYEEYKEYIRRKHLREIEAKQKALG 1438
             |.:....:.|...|            ||.         :..||..:...:|:...::|:
Mouse  1469 SEPKELAGDTGTAPE------------SDA---------EPPEEQTQKQDQKNSDGVDAE----- 1507

  Fly  1439 LTVGAGRGLQARD---RAMLSATKWNAYFNKSRKD---ERQSCMDLQTFTINQPQPRTAPT---C 1494
            |..|....::...   :|:.|.|:.|...:.:..|   .:::|..||.:|.....|:.|.|   |
Mouse  1508 LEEGGPAAVEIDSETAQAVQSLTQENREHDDTFPDCAETQEACRSLQNYTHTDQSPQIATTLDEC 1572

  Fly  1495 TRLERST---------SDLIRAVAEEANIPAPPNLLPPRDYDEAFRNSDYAYPLTVVPDQFSMAY 1550
            .:.:.|:         ...:|:|    |.|:.|          |..|| ||   .:.|||
Mouse  1573 QQSDHSSPVSSVHSHPGQSVRSV----NSPSVP----------ALENS-YA---QISPDQ----- 1614

  Fly  1551 RQFEPAELRAYPLDTALDKPPTDLM--AQLLQAKSEAVGSDEIKTSAPAPKDLGQEQSAIKSVTV 1613
                          ||:..||...|  :.::...|.:..|.::..|..:  |||..:|.
Mouse  1615 --------------TAITVPPLQNMETSPMMDVPSVSDHSQQVVDSGFS--DLGSIEST------ 1657

  Fly  1614 TAPVRRSRRSTRQQTDKVRTASSSSTSSAQSVSSASSGNGSSSDTESGDESDFSSTSSCSSSTGA 1678
                          |:.....||..::...|:    .|||||.             :|||.|:..
Mouse  1658 --------------TENYENPSSYDSTMGGSI----CGNGSSQ-------------NSCSYSSLT 1691

  Fly  1679 SSGAGSEDEDGNECSSSVRLST-CGVCLRSQHRNARDMPEAFIRCYTCRKRVHPSC-VDMPPRMV 1741
            ||....     |.|:.:.::|. .|.|...|..:....|       ||..:....| |:.||
Mouse  1692 SSNLTQ-----NSCAVTQQMSNISGSCSMLQQTSISSPP-------TCSVKSPQGCVVERPP--- 1741

  Fly  1742 GRVRNYNWQCAGCKCCIKCRSSQRPGKMLYCEQCDRGYHIYCLGLRTVPDGRWSCERCCFCMRCG 1806
                               .|||:      ..||.                          |...
Mouse  1742 -------------------SSSQQ------LAQCS--------------------------MAAN 1755

  Fly  1807 ATKPEGLPQVAALSQASGG-----------------PSANGDRSKAARNKRLKWVHEYRIDHVTK 1854
            .|.|..|..:...|.|:.|                 |||....:|      |:.:....|||...
Mouse  1756 FTPPMQLADIPETSNANIGLYERMGQSDFGAGHYPQPSATFSLAK------LQQLTNTLIDHSLP 1814

  Fly  1855 IREHAAMFCVPCARNKPAKRQSAAGAAGAAAVTPVLEATSAQTDDSPMPSPGLTTNGGRA---LS 1916
            ....||:               .:.|..|:..||:......|...||...||    |.:|   ::
Mouse  1815 YSHSAAV---------------TSYANSASLSTPLSNTGLVQLSQSPHSVPG----GPQAQATMT 1860

  Fly  1917 PTAALSPKAAVPVASLPPVLEATTVTTNIAGTIGRRQAGNAVNITTMQCSSSSSSNFSGNGVTED 1981
            |...|:|.   |:...||:|:.....:||..:..:|          :|...:|..:.|.......
Mouse  1861 PPPNLTPP---PMNLPPPLLQRNMAASNIGISHSQR----------LQTQIASKGHVSMRTKAAS 1912

  Fly  1982 AANVTAT-------GTATAAAGAPAAT---------PIGIAPPP 2009
            .:...||       .:.|.|...||.|         .:.:.|.|
Mouse  1913 LSPAAATHQSQIYGRSQTVAMQGPARTLTMQRGMNMSVNLMPAP 1956

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
e(y)3	NP_001259719.1	PHD_SF	1700..1754	CDD:304600	10/55 (18%)
		RanBP2-type Zn finger	1700..1725	CDD:275375	4/25 (16%)
		RanBP2-type Zn finger	1749..1775	CDD:275375	3/25 (12%)
		PHD2_PHF10	1756..1799	CDD:277004	5/42 (12%)
Kat6b	XP_006519326.1	H15	94..168	CDD:197772
		PHD1_MOZ_MORF	213..270	CDD:277090
		PHD2_KAT6A_6B	272..318	CDD:277002
		PLN00104	<721..989	CDD:215056	56/360 (16%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	1	1.000