DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment e(y)3 and mof

DIOPT Version :9

Sequence 1:	NP_001259719.1	Gene:	e(y)3 / 32965	FlyBaseID:	FBgn0087008	Length:	2012	Species:	Drosophila melanogaster
Sequence 2:	NP_511051.1	Gene:	mof / 31518	FlyBaseID:	FBgn0014340	Length:	827	Species:	Drosophila melanogaster

Alignment Length:	546	Identity:	127/546 - (23%)
Similarity:	179/546 - (32%)	Gaps:	137/546 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly   288 ENPAA--SGSNSNSGSCSAA-----VSG------AQSAMPAKND-AHLSSLS----PASASSSSA 334
            |:.||  |.|...|||..:|     :||      |:|..|||.. ..:|.:|    |||::|:|:
  Fly    45 EDAAAELSASLDVSGSDQSAEQSLDLSGVQAEAAAESEPPAKRQHRDISPISEDSTPASSTSTSS 109

  Fly   335 SSSSSSSSSSSLAEMQTVPKLMIKTTLAGSSCISSSEELPQQQQQIPKLTIKTGGGGQEHVHTVI 399
            :.|||||....::|.:..|.             ....|.||||||..|   |..|..|......:
  Fly   110 TRSSSSSRYDDVSEAEEAPP-------------EPEPEQPQQQQQEEK---KEDGQDQVKSPGPV 158

  Fly   400 MTHDLNNAQSIPKLTIKTKSIEMIEDEQAAK---------------------LEQQLQPLPKLT- 442
            .......||...:..:..:.|| .|||.::.                     ::....|...:|
  Fly   159 ELEAQEPAQPQKQKEVVDQEIE-TEDEPSSDTVICVADINPYGSGSNIDDFVMDPDAPPNAIITE 222

  Fly   443 IKNLCSPKHKVRAVLEEKPPTAASKLAIPKPTPNP-------TPAPMTNGGESNSSSQEFCGFSD 500
            :..:.:|.| ::...:...|.||.    |.|.|.|       |||..|:.||            :
  Fly   223 VVTIPAPLH-LKGTQQLGLPLAAP----PPPPPPPAAEQVPETPASPTDDGE------------E 270

  Fly   501 PDADIAAPASDDVRRNSDDMVIDDSLSKEHDPKIFHNLPPMPA---------SNGIASGGSKASK 556
            |.|...:|.............:...|: ..||: ..|:|| ||         |..:.:....:|:
  Fly   271 PPAVYLSPYIRSRYMQESTPGLPTRLA-PRDPR-QRNMPP-PAVVLPIQTVLSANVEAISDDSSE 332

  Fly   557 ASKSAQSQHNVVDMVD-LTSSPSPGSSPTHVPNNFTGRISPKGLLIDCLRMQTAIGCYVPEEADS 620
            .|.|...:....|..| ||......|..|.:.   ||  .|....||.......|  |.....|.
  Fly   333 TSSSDDDEEEEEDEDDALTMEHDNTSRETVIT---TG--DPLMQKIDISENPDKI--YFIRREDG 390

  Fly   621 RVRPAASPNSNILLSQLTAPAKSFTTTTPKSKSSKYPQLTERL---------MANGSGTGGGSVI 676
            .|.     ...:|.|:.|..|     ..|......|..|..||         ..|....||.:|:
  Fly   391 TVH-----RGQVLQSRTTENA-----AAPDEYYVHYVGLNRRLDGWVGRHRISDNADDLGGITVL 445

  Fly   677 AAESEAVVGPLPAANPAQSIIESIEILDTPDGSPRVAYMDEDSNPMLNKHLQTIHKLAMDHGVEQ 741
            .|.      ||....|:    .|.|:| ....:...|...|......||...      :.:....
  Fly   446 PAP------PLAPDQPS----TSREML-AQQAAAAAAASSERQKRAANKDYY------LSYCENS 493

  Fly   742 RMDTQDNNNENHLKRTNSEGNESPSS 767
            |.|..|.....:.||...|.|....|
  Fly   494 RYDYSDRKMTRYQKRRYDEINHVQKS 519

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
e(y)3	NP_001259719.1	PHD_SF	1700..1754	CDD:304600
		RanBP2-type Zn finger	1700..1725	CDD:275375
		RanBP2-type Zn finger	1749..1775	CDD:275375
		PHD2_PHF10	1756..1799	CDD:277004
mof	NP_511051.1	Tudor-knot	382..432	CDD:288553	13/61 (21%)
		NAT_SF	528..813	CDD:302625
		MOZ_SAS	599..778	CDD:280097
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45463886
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	1	0.930