DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment e(y)3 and Phf10

DIOPT Version :9

Sequence 1:	NP_001259719.1	Gene:	e(y)3 / 32965	FlyBaseID:	FBgn0087008	Length:	2012	Species:	Drosophila melanogaster
Sequence 2:	XP_017444365.2	Gene:	Phf10 / 292404	RGDID:	1305266	Length:	556	Species:	Rattus norvegicus

Alignment Length:	665	Identity:	182/665 - (27%)
Similarity:	280/665 - (42%)	Gaps:	152/665 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly  1153 GRG-RGRRSR--GGRGRGSS---SVDRAVSVGGTASTTPATQPRAPRMSRGA----SAVAKAIAM 1207
            ||| ||.|.|  |||..|:.   ...||.:....|:.....:.|..|..|||    :|.....|:
  Rat     7 GRGARGGRGRPPGGRAEGAGPGRRAARATAAAAAAAAAGTRRRRRRRRRRGALGLMAAAGPGAAL 71

  Fly  1208 SRPRCVGGLKHQPDPERLKGLFSPSPQVFEEDTRMSADLSNSNQSMASLMEPPLTPQKQPDFLNN 1272
            |..||      ..||.      ||..|..::|..     .|||...        .|.|:....:.
  Rat    72 SPRRC------DSDPA------SPGAQSPKDDNE-----DNSNDGG--------HPSKRRRMGSG 111

  Fly  1273 EESQSSMVSNVSMMDSNQGQSADAILGSALKRPKKKKMETCVAEDTDYSASSIAEYDWPPPKGCC 1337
            :.|:|...|:..:..|.                              |.|.::.||.||
  Rat   112 DSSRSCETSSQDLSFSY------------------------------YPAENLIEYKWP------ 140

  Fly  1338 PSKNRDTFMIQEQVALYLGITSFKRKYPDLPRRSVDMEERNWLQEKGLVSEKLCDLGITAVWASD 1402
            |.:..:.:|:||||:.|||:||||||||:  ||.:..:|:.:|:|..:::|..|.||:||:.:.:
  Rat   141 PDETGEYYMLQEQVSEYLGVTSFKRKYPE--RRDLSHKEKLYLRELNVITETQCTLGLTALRSDE 203

  Fly  1403 ILDIMYADFFDKYEEYKEYIRRK-------HLREIEAKQKALGLTVGAGRGLQARDRAMLSATKW 1460
            ::|:|..::..|:.||...::.|       |.:|....|:.....|.|.:..:...:|...|.::
  Rat   204 VIDLMIKEYPAKHAEYSVILQEKERQRITDHYKEYSQMQQQSTQKVEASKVPEYIKKAAKKAAEF 268

  Fly  1461 NAYFNKSRKDERQSCMDLQTFTINQPQPRTAPTCTRLERSTSDLIRAVAEEANIPAPPNLLPPRD 1525
            |:..|:.|.:||::..||||..|..||.:.                            .:||
  Rat   269 NSNLNRERMEERRAYFDLQTHVIQVPQGKY----------------------------KVLP--- 302

  Fly  1526 YDEAFRNSDYAYPLTVVPDQFSMAYRQFEPAELRAYPLDTALDKPPTDLMAQLLQAKSEAVGSDE 1590
               ..|....:||:.::|.||...|:::.|.|||..||:|||.:||.|       .:..|:.||
  Rat   303 ---TDRTKVSSYPVALIPGQFQEYYKRYSPDELRYLPLNTALYEPPLD-------PELPALDSD- 356

  Fly  1591 IKTSAPAPKDLGQEQSAIKSVTVTAPVRRSRRSTRQQTDKVRTASSSSTSSAQSVSSASSGNGSS 1655
                  ...|.|::...                     |:.|....:|.||:.:||...|...|.
  Rat   357 ------GDSDDGEDGGG---------------------DEKRKNKGTSDSSSGNVSEGDSPPDSQ 394

  Fly  1656 SDTESGDESDFSSTSSCSSSTGASSGAGSEDEDGNECSSSVRLSTCGVCLRSQHRNARDMPEAFI 1720
            .||..|.:.. ....:.....|:.....|:...|.: ...:..:.||:||:.:..|.:...|:.|
  Rat   395 EDTFQGRQKS-KDKMATPRKDGSKRSVLSKSVPGYK-PKVIPNALCGICLKGKESNKKGKAESLI 457

  Fly  1721 RCYTCRKRVHPSCVDMPPRMVGRVRNYNWQCAGCKCCIKCRSSQRPGKMLYCEQCDRGYHIYCLG 1785
            .|..|....||||:||...:|..::.|.|||..||.||.|.......:|::|:.||||||.:|:|
  Rat   458 HCSQCDNSGHPSCLDMTMELVSMIKTYPWQCMECKTCIICGQPHHEEEMMFCDVCDRGYHTFCVG 522

  Fly  1786 LRTVPDGRWSCERCC 1800
            |..:|.|||.|: ||
  Rat   523 LGAIPSGRWICD-CC 536

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
e(y)3	NP_001259719.1	PHD_SF	1700..1754	CDD:304600	20/53 (38%)
		RanBP2-type Zn finger	1700..1725	CDD:275375	8/24 (33%)
		RanBP2-type Zn finger	1749..1775	CDD:275375	10/25 (40%)
		PHD2_PHF10	1756..1799	CDD:277004	19/42 (45%)
Phf10	XP_017444365.2	WH_NTD_PHF10	133..219	CDD:411035	35/93 (38%)
		PHD1_PHF10	438..491	CDD:277003	20/52 (38%)
		PHD2_PHF10	493..536	CDD:277004	19/43 (44%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166337013
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D312433at33208
OrthoFinder	1	1.000	-	-		FOG0007125
OrthoInspector	1	1.000	-	-		oto96397
orthoMCL	1	0.900	-	-		OOG6_107234
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X5215
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	8	7.750