DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG14221 and Nme8

DIOPT Version :9

Sequence 1:	NP_001259713.1	Gene:	CG14221 / 32961	FlyBaseID:	FBgn0031042	Length:	586	Species:	Drosophila melanogaster
Sequence 2:	NP_853622.2	Gene:	Nme8 / 73412	MGIID:	1920662	Length:	586	Species:	Mus musculus

Alignment Length:	610	Identity:	130/610 - (21%)
Similarity:	215/610 - (35%)	Gaps:	181/610 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MAKKGGVQQLQADLASDEEFEKFLQRSGLLVLDIYSEWCGPCLGMVGSLRKIKLELGGDN-LQLA 64
            ||.|....|||:.:.|...:::.|...||.|:|:|..|||||..:....||:|.||..|. |...
Mouse     1 MASKKREVQLQSVVNSQNLWDEMLLNKGLTVIDVYQAWCGPCKAVQSLFRKLKNELNEDEILHFV 65

  Fly    65 ICKAGSISYLKRFNKKSEPTWMFVTSGKAINIMFGTDVP----KLVAMI---TRMLQSTMAKETH 122
            :.:|.:|..|:.|..|.||.::|..:||.|..:.|.:.|    |::.:|   .:::...|.:..:
Mouse    66 VAEADNIVTLQPFRDKCEPVFLFSLNGKIIAKIQGANAPLINRKVITLIDEERKIVAGEMDRPQY 130

  Fly   123 LSYEITELQPIELEQLEVRNKALRLAEEIELAESRRKRLEYLHSVTDCIMANLPDIGITVFGPQV 187
            :  ||..:..|:.|..||:.::  .||...:|..:                  ||..:.    :.
Mouse   131 V--EIPLVDAIDEEYGEVQYES--AAEVYNMAIIK------------------PDAVLM----RK 169

  Fly   188 NRDMFKKLSEPADPLKIQCKDRKVFTILPSDIATVNFAAENPLSPEVIEQLYDKELLMCFWKVDE 252
            |.::.:|:::....::||                     ||.:.||
Mouse   170 NIEVREKIAKEGFVIEIQ---------------------ENLILPE------------------- 194

  Fly   253 VLGTPPTVLRQ-YAHELTKETIKPPDEFNEEEITVPPMIVPLEVTVEISDPEPSTENSQVQPDAV 316
                  .|:|: |.|      |....:|.|   .|..|...|...:.:|.     |:|:|
Mouse   195 ------EVVREFYTH------IADQPDFEE---FVVSMTNGLSCVLIVSQ-----EDSEV----- 234

  Fly   317 HLAEIRSENVAEAEEETETEAEAGA--APEAKTAPVAAKR------------------------T 355
                |:.|.:    .:|:||.|.|.  .|..:.|||..|:                        .
Mouse   235 ----IQEETL----PQTDTEEEPGVLEEPHVRFAPVMIKKKRDSLQEYMDRQHMSDYCDVEDDAV 291

  Fly   356 KTIRIPPIWVPSDQRTHAALIYTYFRAQTTTFLPPDPVPEPPHIVMI------FDAYKKKDLAIL 414
            |..::..|..|..:...:..:.|     |...|.||...|....|:.      |....::.:.:.
Mouse   292 KVSKLIDILFPDFKTMKSTNVQT-----TLALLHPDICEEEKDDVLNVIHNEGFTILMQRQIVLS 351

  Fly   415 LETCREDIPLY---GFFNGDNPLTAQFIAN-----SVEKYNAKPYVPTDKIVLKVNKVNSPTIPT 471
            .|..|....::   .:|  || |.....:|     ::.:.|...|..|        .:...||..
Mouse   352 EEEARTVCKIHENEEYF--DN-LIGHMTSNHSYVLALRRENGVEYWKT--------LIGPKTIEE 405

  Fly   472 LMAYGPSYVSANSVVGHQEATQFFPANYKSALQEEEELHAVKTEKPKKRKKNKKGGDPEESGKAD 536
            ..|..|..:......|:....||:.::.|:| .|:|..|..                |.:|..|.
Mouse   406 AYASHPQSLCVQFASGNFPTNQFYGSSSKAA-AEKEIAHFF----------------PPQSTLAL 453

  Fly   537 AGPADAQMEAEEAVKTSPEEGASTT 561
            ..|.....|..|.:||..|.|...|
Mouse   454 IKPHVTHKERMEILKTIKEAGFELT 478

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG14221	NP_001259713.1	Thioredoxin_like	11..111	CDD:294274	35/107 (33%)
CG14221	NP_001259713.1	DUF4746	233..508	CDD:292550	58/315 (18%)
Nme8	NP_853622.2	TRX_NDPK	11..113	CDD:239246	34/101 (34%)
		NDPk	155..301	CDD:260363	39/240 (16%)
		NDK 1	157..254		32/191 (17%)
		NDK 2	312..452		32/172 (19%)
		NDK	313..450	CDD:197791	31/169 (18%)
		NDPk_TX	313..445	CDD:239879	30/148 (20%)
		NDK	448..581	CDD:197791	10/31 (32%)
		NDPk	448..579	CDD:260363	10/31 (32%)
		NDK 3	453..586		8/26 (31%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	72	1.000	Domainoid score	I9301
eggNOG	1	0.900	-	-		E2759_KOG0907
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0	Normalized mean entropy	S4604
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR46135
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X3807
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	5	4.950