Protein Alignment CG14221 and NME8

DIOPT Version :9

• Sequence 1: NP_001259713.1
• Gene: CG14221 / 32961
• FlyBaseID: FBgn0031042
• Length: 586
• Species: Drosophila melanogaster
• Sequence 2: NP_057700.3
• Gene: NME8 / 51314
• HGNCID: 16473
• Length: 588
• Species: Homo sapiens
• Alignment Length: 570
• Identity: 125/570 - (21%)
• Similarity: 210/570 - (36%)
• Gaps: 153/570 - (26%)

  Fly     1 MAKKGGVQQLQADLASDEEFEKFLQRSGLLVLDIYSEWCGPCLGMVGSLRKIKLELGGDN-LQLA 64
            ||.|....|||..:.:...:::.||..||.|:|:|..|||||..|....||:|.||..|. |..|
Human     1 MASKKREVQLQTVINNQSLWDEMLQNKGLTVIDVYQAWCGPCRAMQPLFRKLKNELNEDEILHFA 65

  Fly    65 ICKAGSISYLKRFNKKSEPTWMFVTSGKAINIMFGTDVP----KLVAMITRMLQSTMAKETHLSY 125
            :.:|.:|..|:.|..|.||.::|..:||.|..:.|.:.|    |::.:|....:....:.....|
Human    66 VAEADNIVTLQPFRDKCEPVFLFSVNGKIIEKIQGANAPLVNKKVINLIDEERKIAAGEMARPQY 130

  Fly   126 EITELQPIELEQLEVRNKALRLAEEIELAESRRKRLEYLHSVTDCIMANLPDIGITVFGPQVNRD 190
            ....|...:.|..|               ||..:.::.|:|:  .|:.  ||..|:
Human   131 PEIPLVDSDSEVSE---------------ESPCESVQELYSI--AIIK--PDAVIS--------- 167

  Fly   191 MFKKLSEPADPLKIQCKDRKVFTILPSDIATVNFAAENPLSPEVIEQLYDKELLMCFWKVDEVLG 255
              ||:      |:|:.|..|...|:.::..||       |:.|.:...|.:....|  ..:|.:.
Human   168 --KKV------LEIKRKITKAGFIIEAEHKTV-------LTEEQVVNFYSRIADQC--DFEEFVS 215

  Fly   256 TPPTVLRQYAHELTKETIKPPDEFNEEEITVPPMIVPLEVTVEISDPEPSTENSQVQP------- 313
            ...:.|.............||.|..|.:....|.        |.|:.:|..| :||.|
Human   216 FMTSGLSYILVVSQGSKHNPPSEETEPQTDTEPN--------ERSEDQPEVE-AQVTPGMMKNKQ 271

  Fly   314 -------DAVHLAEIRSENVAEAEEETETEAEAGAA--PEAKTAPVAAKRTKTIRIPPIWVPSDQ 369
                   :..|||::     .:.||:....|:...|  |:       .|:.|::::        :
Human   272 DSLQEYLERQHLAQL-----CDIEEDAANVAKFMDAFFPD-------FKKMKSMKL--------E 316

  Fly   370 RTHAALIYTYFRAQTTTFL-----PPDPVPEPPHIVMIFDAYKKKDLAILLETCREDIPLYGFFN 429
            :|.|.|....|..:....|     ....:.|...:|:    .:|:..|:..|...||     :||
Human   317 KTLALLRPNLFHERKDDVLRIIKDEDFKILEQRQVVL----SEKEAQALCKEYENED-----YFN 372

  Fly   430 GDNPLTAQFIANSVEKYNAKPYVPTDKIVLKVN------KVNSP-TIPTLMAYGPSYVSA----- 482
                       ..:|...:.|.:..  ::|:.|      ::..| |:...:.|.|..:.|
Human   373 -----------KLIENMTSGPSLAL--VLLRDNGLQYWKQLLGPRTVEEAIEYFPESLCAQFAMD 424

  Fly   483 ----NSVVG-------HQEATQFFPAN--------YKSALQEEEELHAVK 513
                |.:.|       .:|...|||..        :.::.|.|:.|..||
Human   425 SLPVNQLYGSDSLETAEREIQHFFPLQSTLGLIKPHATSEQREQILKIVK 474

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG14221	NP_001259713.1	Thioredoxin_like	11..111	CDD:294274	37/104 (36%)
		DUF4746	233..508	CDD:292550	58/326 (18%)
NME8	NP_057700.3	TRX_NDPK	11..113	CDD:239246	36/101 (36%)
		NDPk_TX	154..304	CDD:239879	40/193 (21%)
		NDK 1	157..257		26/137 (19%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	230..261		9/39 (23%)
		NDK 2	315..455		29/169 (17%)
		NDK	316..453	CDD:197791	29/158 (18%)
		NDPk_TX	316..448	CDD:239879	26/153 (17%)
		NDK	451..586	CDD:197791	5/24 (21%)
		NDPk_TX	451..582	CDD:239879	5/24 (21%)
		NDK 3	456..588		5/19 (26%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	70	1.000	Domainoid score	I9549
eggNOG	1	0.900	-	-		E2759_KOG0907
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR46135
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X3807
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	4	4.000