DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG14221 and Txndc2

DIOPT Version :9

Sequence 1:	NP_001259713.1	Gene:	CG14221 / 32961	FlyBaseID:	FBgn0031042	Length:	586	Species:	Drosophila melanogaster
Sequence 2:	NP_001139474.1	Gene:	Txndc2 / 213272	MGIID:	2389312	Length:	550	Species:	Mus musculus

Alignment Length:	378	Identity:	75/378 - (19%)
Similarity:	136/378 - (35%)	Gaps:	124/378 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly   227 ENPLS----------PEVIEQLYDKELLMCFWKVDEVLGTPPTVLRQYAHELTKETIKPPDEFNE 281
            ||||.          ||.::....||..:.. ||...|           |..|:|:..|
Mouse    51 ENPLQALSKNEAFLVPEFLDTAQSKEKAIAS-KVSNTL-----------HMSTEESEFP------ 97

  Fly   282 EEITVPPMIVPLEVTV----EISDPEPSTENSQVQPDAVHLAEIRSENVAEAEEETETEAEAGAA 342
            ::::..||.  .|.||    |:| |:||::|:|          ::.||::::...:: :......
Mouse    98 QQVSSTPMF--SENTVHPRHEVS-PKPSSKNTQ----------LKQENISKSSGYSK-QTNYSNT 148

  Fly   343 PEAKTAPVAAKRTKTIRIPPIWVPSDQRTHAALIYTYFRAQTTTFLPPDPVPEPPHIVMIFDAYK 407
            |::.......|:..|::      |:...||                                 |:
Mouse   149 PKSLAKTTHPKQGSTLK------PATNSTH---------------------------------YR 174

  Fly   408 KKDLAILLETCREDI--PLYGFFNGDNPLTAQFIANSVEKYNAKPYVPTDKIVLKVNKVNSPTIP 470
            :.|    :....|||  |.    .||.|.:::.|..|  |...:|....|  :::..|.:.|.
Mouse   175 EDD----IPKSSEDIIQPK----KGDRPKSSEDIIQS--KKEDRPKSSED--IIQSKKEDRPK-- 225

  Fly   471 TLMAYGPSYVSANSVVGHQEATQFFPANYKSALQEEEELHAVKTE---KPKKRKKNKKGGDPEES 532
                      |:..::  |...:..|.:.:..:|.::|.....:|   :|||..:.|...|...|
Mouse   226 ----------SSEDII--QSKKEDRPKSSEDIIQSKKEDRPKSSEDIIQPKKEDRPKSSEDSVPS 278

  Fly   533 GKADAGPADAQMEAEEAVKTSPEEGASTTSSGEDSCESRPATADGANPDASQA 585
            .|     .|....:|::|:...|:   ...|.|||.:|:.........|:.|:
Mouse   279 KK-----GDRPKSSEDSVQPKKED---RPKSSEDSVQSKEGEVHKPLKDSIQS 323

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG14221	NP_001259713.1	Thioredoxin_like	11..111	CDD:294274
CG14221	NP_001259713.1	DUF4746	233..508	CDD:292550	50/280 (18%)
Txndc2	NP_001139474.1	TRX_family	454..546	CDD:239245
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167847090
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0907
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1482186at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	3.750